公开(公告)号：US20230024554A1

公开(公告)日：2023-01-26

申请号：US17847987

申请日：2022-06-23

Applicant: Immatics Biotechnologies GmbH

Inventor： Christoph SCHRAEDER ,  Heiko SCHUSTER ,  Lena Katharina FREUDENMANN ,  Valentina GOLDFINGER ,  Daniel Johannes KOWALEWSKI ,  Sara YOUSEF ,  Timo MANZ ,  Vedrana MIJOSEK ,  Michael ROEMER ,  Toni WEINSCHENK

IPC: G01N33/543 ,  G01N21/552 ,  G16B20/30 ,  C07K7/06 ,  C07K7/08 ,  C07K16/28 ,  C12N5/0783

Abstract: The present invention relates to a method of characterizing the binding characteristics between a peptide of interest and MHC molecules of a given cell type, the method comprising the steps of: (i) Providing two or more cells characterized by displaying, on their surface, MHC molecules, (ii) dispensing the two or more cells in two or more vessels, so that each vessel comprises one or more cells, (iii) adding, to the different vessels, different variants of a peptide of interest, wherein the variants of said peptide are labeled and have the same amino acid sequence, yet differ from one another in the type of labeling and their concentration, and exposing the cells thereto so as to form, in the different vessels, peptide-MHC complexes on the surface of the cells, (iv) isolating the thus formed peptide-MHC complexes and (v) determining the concentration of the different peptide-MHC complexes formed (FIG. 1).

公开(公告)号：US20250034227A1

公开(公告)日：2025-01-30

申请号：US18785378

申请日：2024-07-26

Applicant: Immatics Biotechnologies GmbH

Inventor： Felix UNVERDORBEN ,  Sebastian BUNK ,  Martin HOFMANN ,  Meike HUTT ,  Timo MANZ ,  Nadine ASCHMONEIT ,  Maike JAWORSKI ,  Lena SCHMOHL ,  Claudia WAGNER ,  Dominik MAURER ,  Heiko SCHUSTER ,  Nora TREIBER

IPC: C07K14/725 ,  A61K38/00 ,  A61P35/00

Abstract: The present invention relates to antigen binding proteins that specifically bind to a tumor expressed melanoma-associated antigen (MAGE) B2 antigenic peptide in a complex with MHC. The antigen binding proteins are provided for use in the treatment of MAGEB2-expressing cancers. Further provided are nucleic acids encoding the antigen binding proteins, vectors comprising the nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins.