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公开(公告)号：US20240239867A1
公开(公告)日：2024-07-18
申请号：US18433955
申请日：2024-02-06
Applicant: Immatics Biotechnologies GmbH
Inventor： Jens HUKELMANN , Heiko SCHUSTER , Lena WULLKOPF , Christoph SCHRAEDER , Jens FRITSCHE , Daniel Johannes KOWALEWSKI , Michael ROEMER , Oliver SCHOOR
IPC: C07K14/725 , A61K35/17 , A61K38/00 , C07K14/74 , C07K16/28
CPC classification number: C07K14/7051 , A61K35/17 , C07K14/70539 , C07K16/2833 , A61K38/00 , C07K2319/30
Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240218044A1
公开(公告)日：2024-07-04
申请号：US18421973
申请日：2024-01-24
Applicant: Immatics Biotechnologies GmbH
Inventor： Jens HUKELMANN , Heiko SCHUSTER , Lena WULLKOPF , Christoph SCHRAEDER , Jens FRITSCHE , Daniel Johannes KOWALEWSKI , Michael ROEMER , Oliver SCHOOR
IPC: C07K14/725 , A61K35/17 , A61K38/00 , C07K14/74 , C07K16/28
CPC classification number: C07K14/7051 , A61K35/17 , C07K14/70539 , C07K16/2833 , A61K38/00 , C07K2319/30
Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240166714A1
公开(公告)日：2024-05-23
申请号：US18433913
申请日：2024-02-06
Applicant: Immatics Biotechnologies GmbH
Inventor： Jens HUKELMANN , Heiko SCHUSTER , Lena WULLKOPF , Christoph SCHRAEDER , Jens FRITSCHE , Daniel Johannes KOWALEWSKI , Michael ROEMER , Oliver SCHOOR
IPC: C07K14/725 , A61K35/17 , C07K14/74 , C07K16/28
CPC classification number: C07K14/7051 , A61K35/17 , C07K14/70539 , C07K16/2833 , A61K38/00
Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240166712A1
公开(公告)日：2024-05-23
申请号：US18433852
申请日：2024-02-06
Applicant: Immatics Biotechnologies GmbH
Inventor： Jens HUKELMANN , Heiko SCHUSTER , Lena WULLKOPF , Christoph SCHRAEDER , Jens FRITSCHE , Daniel Johannes KOWALEWSKI , Michael ROEMER , Oliver SCHOOR
IPC: C07K14/725 , A61K35/17 , C07K14/74 , C07K16/28
CPC classification number: C07K14/7051 , A61K35/17 , C07K14/70539 , C07K16/2833 , A61K38/00
Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240117004A1
公开(公告)日：2024-04-11
申请号：US18544048
申请日：2023-12-18
Applicant: Immatics Biotechnologies GmbH
Inventor： Jens HUKELMANN , Heiko SCHUSTER , Lena WULLKOPF , Christoph SCHRAEDER , Jens FRITSCHE , Daniel Johannes KOWALEWSKI , Michael ROEMER , Oliver SCHOOR
IPC: C07K14/725 , A61K35/17 , C07K14/74 , C07K16/28
CPC classification number: C07K14/7051 , A61K35/17 , C07K14/70539 , C07K16/2833 , A61K38/00
Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
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Patent Agency Ranking
公开(公告)号：US20220289816A1
公开(公告)日：2022-09-15
申请号：US17826557
申请日：2022-05-27
Applicant: Immatics Biotechnologies GmbH
Inventor： Heiko SCHUSTER , Daniel Johannes KOWALEWSKI , Oliver SCHOOR , Jens FRITSCHE , Toni WEINSCHENK , Harpreet SINGH , Gisela SCHIMMACK , Michael ROEMER
IPC: C07K14/725 , C12N5/0783 , A61P35/00 , G01N33/574 , C07K16/28 , C07K14/74 , A61K35/17 , A61K9/19 , A61K39/00 , G16B25/10 , C12N15/115
Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US20220283176A1
公开(公告)日：2022-09-08
申请号：US17686224
申请日：2022-03-03
Applicant: Immatics Biotechnologies GmbH
Inventor： Christoph SCHRAEDER , Heiko SCHUSTER , Lena Katharina FREUDENMANN , Lida ROSTOCK , Linus BACKERT , Michael ROEMER , Daniel Johannes KOWALEWSKI
Abstract: The present invention relates to a method for the absolute quantification of one or more MHC molecules in a test sample comprising at least one cell, the method comprising at least the steps of: homogenizing the sample, adding an internal standard to the sample, digesting the homogenized sample with a protease, before or after addition of the internal standard, purifying the sample obtained by the digestion, subjecting the digested sample to a step of chromatography and/or spectrometry analysis, and quantifying the one or more MHC molecules in the test sample Also, the invention relates to method of determining the cell count in a sample. (FIG. 1).
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公开(公告)号：US20220267408A1
公开(公告)日：2022-08-25
申请号：US17738453
申请日：2022-05-06
Applicant: Immatics Biotechnologies GmbH
Inventor： Heiko SCHUSTER , Daniel Johannes KOWALEWSKI , Oliver SCHOOR , Jens FRITSCHE , Toni WEINSCHENK , Harpreet SINGH , Gisela SCHIMMACK , Michael ROEMER
IPC: C07K14/725 , C12N5/0783 , A61P35/00 , G01N33/574 , C07K16/28 , C07K14/74 , A61K35/17 , A61K9/19 , A61K39/00 , G16B25/10 , C12N15/115
Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US20250145684A1
公开(公告)日：2025-05-08
申请号：US19015015
申请日：2025-01-09
Applicant: Immatics Biotechnologies GmbH
Inventor： Gisela SCHIMMACK , Annika SONNTAG , Heiko SCHUSTER , Daniel Johannes KOWALEWSKI , Michael ROEMER , Jens FRITSCHE , Oliver SCHOOR , Toni WEINSCHENK , Harpreet SINGH
IPC: C07K14/73 , A61K35/17 , A61K39/00 , C07K7/00 , C07K14/705 , C07K14/74 , C07K16/00 , C12N5/0783
Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US20240374640A1
公开(公告)日：2024-11-14
申请号：US18599838
申请日：2024-03-08
Applicant: Immatics Biotechnologies GmbH
Inventor： Ricarda HANNEN , Jens HUKELMANN , Florian KOEHLER , Daniel Johannes KOWALEWSKI , Heiko SCHUSTER , Oliver SCHOOR , Michael ROEMER , Chih-Chiang TSOU , Jens FRITSCHE
IPC: A61K35/17 , A61K39/00 , A61P35/00 , C07K14/47 , C12N5/0783
Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 216, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
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