公开(公告)号：US20220056411A1

公开(公告)日：2022-02-24

申请号：US17409504

申请日：2021-08-23

Applicant: Immatics US, Inc.

Inventor： Mamta KALRA ,  Gagan BAJWA ,  Thomas LUCAS ,  Ali MOHAMED ,  Steffen WALTER

IPC: C12N5/0783 ,  C12N15/85 ,  C07K14/725

Abstract: A method of producing an engineered T cell population includes obtaining a cell population comprising a CD8+ T cell, isolating the CD8+ T cell from the obtained cell population, activating the isolated CD8+ T cell, introducing a nucleic acid encoding a T cell receptor (TCR) binding to an antigen in a complex with an MHC molecule into the activated CD8+ T cell, and expanding the introduced CD8+ T cell to obtain the engineered T cell population.