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公开(公告)号：US20250034588A1
公开(公告)日：2025-01-30
申请号：US18897063
申请日：2024-09-26
Applicant: Immatics US, Inc.
Inventor： Mamta KALRA , Agathe BOURGOGNE , Ali MOHAMED , Steffen WALTER
Abstract: The present disclosure relates to T cells transduced with a viral vector at a volumetric concentration for immunotherapy and methods thereof. In another aspect, the present disclosure relates to the assessment of optimal lentiviral vector concentrations for transducing T cells. The present disclosure further provides for T cell populations produced by methods described herein.
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公开(公告)号：US20250075230A1
公开(公告)日：2025-03-06
申请号：US18824203
申请日：2024-09-04
Applicant: Immatics US, Inc.
Inventor： Melinda MATA , Mamta KALRA , Yannick BULLIARD , Steffen WALTER , Ali MOHAMED
IPC: C12N15/86 , A61K39/00 , C07K14/725 , C12N5/0783 , C12N15/10 , C12N15/113
Abstract: The present invention provides a mutated woodchuck post-transcriptional regulatory element (WPRE). In particular, the present invention relates to a mutated WPRE sequence that can efficiently express nucleotides of interest in a retroviral vector system. The present invention also relates to methods of delivering and expressing nucleotides of interest to a target cell.
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公开(公告)号：US20220056411A1
公开(公告)日：2022-02-24
申请号：US17409504
申请日：2021-08-23
Applicant: Immatics US, Inc.
Inventor： Mamta KALRA , Gagan BAJWA , Thomas LUCAS , Ali MOHAMED , Steffen WALTER
IPC: C12N5/0783 , C12N15/85 , C07K14/725
Abstract: A method of producing an engineered T cell population includes obtaining a cell population comprising a CD8+ T cell, isolating the CD8+ T cell from the obtained cell population, activating the isolated CD8+ T cell, introducing a nucleic acid encoding a T cell receptor (TCR) binding to an antigen in a complex with an MHC molecule into the activated CD8+ T cell, and expanding the introduced CD8+ T cell to obtain the engineered T cell population.
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公开(公告)号：US20190247433A1
公开(公告)日：2019-08-15
申请号：US16271393
申请日：2019-02-08
Applicant: Immatics US, Inc.
Inventor： Mamta KALRA , Zoe COUGHLIN , Amir ALPERT , Steffen WALTER , Ali MOHAMED , Agathe BOURGOGNE
CPC classification number: A61K35/17 , A61P31/00 , A61P35/00 , C07K16/2809 , C07K16/2818 , C12N5/0636 , C12N5/0637 , C12N5/0638 , C12N15/86 , C12N2501/2302 , C12N2501/2307 , C12N2501/2312 , C12N2501/2315 , C12N2501/2321 , C12N2501/51 , C12N2501/515 , C12N2510/00
Abstract: The disclosure relates to methods of manufacturing T cells for adoptive immunotherapy. The disclosure further provides for methods of genetically transducing T cells, methods of using T cells, and T cell populations thereof. In an aspect, the disclosure provides for methods of thawing frozen peripheral blood mononuclear cells (PBMC), resting the thawed PBMC, activating the T cell in the cultured PBMC with an anti-CD3 antibody and an anti-CD28 antibody immobilized on a solid phase, transducing the activated T cell with a viral vector, expanding the transduced T cell, and obtaining expanded T cells.
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公开(公告)号：US20240150790A1
公开(公告)日：2024-05-09
申请号：US18501269
申请日：2023-11-03
Applicant: Immatics US, Inc.
Inventor： Melinda MATA , Mamta KALRA , Yannick BULLIARD , Steffen WALTER , Ali MOHAMED
IPC: C12N15/86 , C07K14/725 , C12N15/10 , C12N15/113
CPC classification number: C12N15/86 , C07K14/7051 , C12N15/102 , C12N15/113 , C12N2830/48
Abstract: The present invention provides a mutated woodchuck post-transcriptional regulatory element (WPRE). In particular, the present invention relates to a mutated WPRE sequence that can efficiently express nucleotides of interest in a retroviral vector system. The present invention also relates to methods of delivering and expressing nucleotides of interest to a target cell.
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Patent Agency Ranking
公开(公告)号：US20220280564A1
公开(公告)日：2022-09-08
申请号：US17281095
申请日：2021-02-23
Applicant: Immatics US, Inc.
Inventor： Melinda MATA , Mamta KALRA , Ali MOHAMED , Steffen WALTER , Yannick BULLIARD
IPC: A61K35/17 , C07K14/725 , C12N5/0783
Abstract: An in vitro method of expanding γδ T cells includes isolating γδ T cells from a blood sample of a human subject, activating the isolated γδ T cells in the presence of an aminobisphosphonate and/or a feeder cell and at least one cytokine, expanding the activated γδ T cells, and optionally restimulating the expanded γδ T cells.
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公开(公告)号：US20190216852A1
公开(公告)日：2019-07-18
申请号：US16250679
申请日：2019-01-17
Applicant: Immatics US, Inc.
Inventor： Mamta KALRA , Agathe BOURGOGNE , Ali MOHAMED , Steffen WALTER
CPC classification number: A61K35/17 , A61P35/00 , C12N7/00 , C12N15/8509
Abstract: The present disclosure relates to T cells transduced with a viral vector at a volumetric concentration for immunotherapy and methods thereof. In another aspect, the present disclosure relates to the assessment of optimal lentiviral vector concentrations for transducing T cells. The present disclosure further provides for T cell populations produced by methods described herein.
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公开(公告)号：US20250002855A1
公开(公告)日：2025-01-02
申请号：US18886331
申请日：2024-09-16
Applicant: Immatics US, Inc.
Inventor： Melinda MATA , Mamta KALRA , Ali MOHAMED , Steffen WALTER , Yannick BULLIARD
IPC: C12N5/0783 , A61K39/00 , C07K14/725
Abstract: An in vitro method of expanding γδ T cells includes isolating γδ T cells from a blood sample of a human subject, activating the isolated γδ T cells in the presence of an aminobisphosphonate and/or a feeder cell and at least one cytokine, expanding the activated γδ T cells, and optionally restimulating the expanded γδ T cells.
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公开(公告)号：US20210285011A1
公开(公告)日：2021-09-16
申请号：US17197927
申请日：2021-03-10
Applicant: Immatics US, Inc.
Inventor： Melinda MATA , Mamta KALRA , Yannick BULLIARD , Steffen WALTER , Ali MOHAMED
IPC: C12N15/86 , C12N15/10 , C07K14/725 , C12N15/113
Abstract: The present invention provides a mutated woodchuck post-transcriptional regulatory element (WPRE). In particular, the present invention relates to a mutated WPRE sequence that can efficiently express nucleotides of interest in a retroviral vector system. The present invention also relates to methods of delivering and expressing nucleotides of interest to a target cell.
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公开(公告)号：US20210002610A1
公开(公告)日：2021-01-07
申请号：US16893246
申请日：2020-06-04
Applicant: Immatics US, Inc. , Immatics Biotechnologies GmbH
Inventor： Amir ALPERT , Dominik MAURER , Anastasiya SMITH , Claudia WAGNER , Ali MOHAMED
IPC: C12N5/0783 , A61K31/5383 , A61K31/437
Abstract: Described herein are methods for preparing T cells, including isolating CD8+ T cells from a blood sample obtained from a patient or a donor, culturing the isolated CD8+ T cells in the presence of at least one cytokine, contacting the cultured CD8+ T cells with a multimer containing a target peptide in a complex with an MHC molecule and with at least one binding agent that binds to a T cell surface molecule, in which the multimer is labelled with a first detectable agent and the binding agent is labelled with a second detectable agent, sorting the contacted CD8+ T cells to collect the sorted CD8+ T cells that are detected positive for the first and the second detectable agents, and expanding the collected CD8+ T cells.
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