公开(公告)号：US11613755B2

公开(公告)日：2023-03-28

申请号：US17132793

申请日：2020-12-23

Applicant: Industrial Technology Research Institute

Inventor： Ping-Fu Cheng ,  Ya-Ling Chiu ,  Kang-Li Wang ,  Po-Yen Lin ,  Shih-Ta Chen ,  Tseng-Huang Liu ,  Pei-Shin Jiang

IPC: C12N15/115 ,  A61K47/54 ,  A61P35/00 ,  A61K9/00 ,  C12N15/113

Abstract: A nucleic acid-drug complex is provided in the present disclosure, which includes a nucleic acid sequence of an anti-PD-L1 aptamer and a CpG oligonucleotide sequence capable of activating TLR9, in which the CpG oligonucleotide sequence consists of a first fragment and a second fragment, and the nucleic acid sequence of the anti-PD-L1 aptamer is inserted between the first fragment and the second fragment.