公开(公告)号：US09791460B2

公开(公告)日：2017-10-17

申请号：US14105891

申请日：2013-12-13

Applicant: Industrial Technology Research Institute

Inventor： Tzu-Ling Tseng ,  Hung-Yi Li ,  Yen-Peng Li ,  Angelina Huai-Lo Lee ,  Yi-Chen Liu ,  Ping-Fu Cheng ,  Wei-Ya Lin ,  Hong-Zen Yeh

IPC: G01N33/53 ,  G01N33/49 ,  G01N33/50 ,  G01N33/576 ,  G01N33/487 ,  G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/487 ,  G01N33/49 ,  G01N33/50 ,  G01N33/5067 ,  G01N33/53 ,  G01N33/576 ,  G01N2333/70539 ,  G01N2333/96494 ,  G01N2333/9723 ,  G01N2800/085

Abstract: Identification of urokinase-type plasminogen, matrix metalloproteinase 9, and β-2-microglobulin as novel biomarkers associated with liver fibrosis and uses thereof in diagnosing liver fibrosis.

公开(公告)号：US20140106370A1

公开(公告)日：2014-04-17

申请号：US14105891

申请日：2013-12-13

Applicant: Industrial Technology Research Institute

Inventor： Tzu-Ling Tseng ,  Hong-Yi Li ,  Ye-Peng Li ,  Angelina Huai-Lo Lee ,  Yi-Chen Liu ,  Ping-Fu Cheng ,  Wei-Ya Lin ,  Hong-Zen Yeh

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/487 ,  G01N33/49 ,  G01N33/50 ,  G01N33/5067 ,  G01N33/53 ,  G01N33/576 ,  G01N2333/70539 ,  G01N2333/96494 ,  G01N2333/9723 ,  G01N2800/085

Abstract: Identification of urokinase-type plasminogen, matrix metalloproteinase 9, and β-2-microglobulin as novel biomarkers associated with liver fibrosis and uses thereof in diagnosing liver fibrosis.

Abstract translation: 鉴定尿激酶型纤溶酶原，基质金属蛋白酶9和＆bgr.2-微球蛋白作为与肝纤维化相关的新型生物标志物及其在诊断肝纤维化中的用途。

公开(公告)号：US11613755B2

公开(公告)日：2023-03-28

申请号：US17132793

申请日：2020-12-23

Applicant: Industrial Technology Research Institute

Inventor： Ping-Fu Cheng ,  Ya-Ling Chiu ,  Kang-Li Wang ,  Po-Yen Lin ,  Shih-Ta Chen ,  Tseng-Huang Liu ,  Pei-Shin Jiang

IPC: C12N15/115 ,  A61K47/54 ,  A61P35/00 ,  A61K9/00 ,  C12N15/113

Abstract: A nucleic acid-drug complex is provided in the present disclosure, which includes a nucleic acid sequence of an anti-PD-L1 aptamer and a CpG oligonucleotide sequence capable of activating TLR9, in which the CpG oligonucleotide sequence consists of a first fragment and a second fragment, and the nucleic acid sequence of the anti-PD-L1 aptamer is inserted between the first fragment and the second fragment.

公开(公告)号：US20180169262A1

公开(公告)日：2018-06-21

申请号：US15830272

申请日：2017-12-04

Applicant: Industrial Technology Research Institute

Inventor： Maggie Lu ,  May-Hua Chang ,  Jenn-Tsang Hwang ,  Ping-Fu Cheng ,  Li-Wen Chang ,  Yi-Ju Ko ,  Chi-Y Hung ,  Chun-Min Liu ,  Chia-Yu Fan

IPC: A61K47/68 ,  A61K31/4745 ,  A61K47/64 ,  C07K16/30

CPC classification number: A61K47/6889 ,  A61K31/4745 ,  A61K47/64 ,  A61K47/65 ,  A61K47/6803 ,  A61K47/6817 ,  A61K47/6851 ,  A61K47/6855 ,  A61P35/00 ,  C07K16/30

Abstract: A linker-drug represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), C is a conjugator, L is a linker unit, D is a toxin unit, and n is an integer ranging from 1 to 4. The structure of the conjugator is represented by formula (II). In formula (II), X is a leaving group, each of R1 and R2 is independently a single bond or —NH—, and Z is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or a combination thereof. The antibody is conjugated to the linker unit through a cysteine residue of the antibody. An antibody-drug conjugate (ADC) employing the above linker-drug is also provided.

公开(公告)号：US20130252267A1

公开(公告)日：2013-09-26

申请号：US13901819

申请日：2013-05-24

Applicant: Industrial Technology Research Institute

Inventor： Wei-Ya Lin ,  Mary Ya-Ping Yeh ,  Tzu-Ling Tseng ,  Ping-Fu Cheng ,  Tsai-Wei Hsu ,  Hung-Yi Li ,  Yi-Ting Chen ,  Yuh-Feng Ling ,  Jin-Shuen Chen ,  Yen-Peng Li

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N2333/4728 ,  G01N2333/52 ,  G01N2333/71 ,  G01N2333/8125 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56

Abstract: Described are uses of urine and serum biomarkers in diagnosing diabetic nephropathy, staging diabetic nephropathy, monitoring diabetic nephropathy progress, and assessing efficacy of diabetic nephropathy treatments. These biomarkers include urine precursor alpha-2-HS-glycoprotein, urine alpha-1 antitrypsin, urine alpha-1 acid glycoprotein, urine osteopontin, serum osteopontin, their fragments, and combinations thereof.

Abstract translation: 描述了尿和血清生物标志物在诊断糖尿病肾病，分期糖尿病肾病，监测糖尿病肾病进展以及评估糖尿病肾病治疗效果方面的应用。 这些生物标志物包括尿前体α-2-HS-糖蛋白，尿α-1抗胰蛋白酶，尿α-1酸糖蛋白，尿骨桥蛋白，血清骨桥蛋白，其片段及其组合。

公开(公告)号：US20240189243A1

公开(公告)日：2024-06-13

申请号：US18507536

申请日：2023-11-13

Applicant: Industrial Technology Research Institute

Inventor： Felice Cheng ,  Ping-Fu Cheng ,  Jenn-Tsang Hwang ,  Chih-Wei Fu ,  Ku-Feng Lin ,  Ya-Ling Chiu ,  Jheng-Sian Li ,  Kang-Li Wang ,  Siou-Han Chang ,  Chia-Yu Fan

IPC: A61K9/51 ,  A61K31/7105 ,  A61K31/711 ,  A61K47/28 ,  C07F9/09 ,  C07F9/535 ,  C07F9/6509 ,  C07F9/6512

CPC classification number: A61K9/5123 ,  A61K31/7105 ,  A61K31/711 ,  A61K47/28 ,  C07F9/091 ,  C07F9/535 ,  C07F9/650952 ,  C07F9/6512

Abstract: A lipid compound or a derivative thereof and a pharmaceutical composition employing the same are provided. The lipid compound has a structure represented by Formula (I):






wherein Z1, Z2, Z3 and Z4 are as disclosed in the specification.

公开(公告)号：US09983216B2

公开(公告)日：2018-05-29

申请号：US15706011

申请日：2017-09-15

Applicant: Industrial Technology Research Institute

Inventor： Tzu-Ling Tseng ,  Hung-Yi Li ,  Yen-Peng Li ,  Angelina Huai-Lo Lee ,  Yi-Chen Liu ,  Ping-Fu Cheng ,  Wei-Ya Lin ,  Hong-Zen Yeh

IPC: G01N33/53 ,  G01N33/49 ,  G01N33/576 ,  G01N33/487 ,  G01N33/68 ,  G01N33/50

CPC classification number: G01N33/6893 ,  G01N33/487 ,  G01N33/49 ,  G01N33/50 ,  G01N33/5067 ,  G01N33/53 ,  G01N33/576 ,  G01N2333/70539 ,  G01N2333/96494 ,  G01N2333/9723 ,  G01N2800/085

Abstract: Identification of urokinase-type plasminogen, matrix metalloproteinase 9, and β-2-microglobulin as novel biomarkers associated with liver fibrosis and uses thereof in diagnosing and staging liver fibrosis.

公开(公告)号：US20180003722A1

公开(公告)日：2018-01-04

申请号：US15706011

申请日：2017-09-15

Applicant: Industrial Technology Research Institute

Inventor： Tzu-Ling Tseng ,  Hung-Yi Li ,  Yen-Peng Li ,  Angelina Huai-Lo Lee ,  Yi-Chen Liu ,  Ping-Fu Cheng ,  Wei-Ya Lin ,  Hong-Zen Yeh

IPC: G01N33/68 ,  G01N33/487 ,  G01N33/50 ,  G01N33/53 ,  G01N33/576 ,  G01N33/49

CPC classification number: G01N33/6893 ,  G01N33/487 ,  G01N33/49 ,  G01N33/50 ,  G01N33/5067 ,  G01N33/53 ,  G01N33/576 ,  G01N2333/70539 ,  G01N2333/96494 ,  G01N2333/9723 ,  G01N2800/085

Abstract: Identification of urokinase-type plasminogen, matrix metalloproteinase 9, and β-2-microglobulin as novel biomarkers associated with liver fibrosis and uses thereof in diagnosing and staging liver fibrosis.