公开(公告)号：US20060122113A1

公开(公告)日：2006-06-08

申请号：US11223408

申请日：2005-09-09

申请人： Irit Pinchasi ,  Ben-Zion Dolitzky ,  Anton Frenkel ,  Michal Schwartz ,  Ruth Arnon ,  Rina Aharoni

发明人： Irit Pinchasi ,  Ben-Zion Dolitzky ,  Anton Frenkel ,  Michal Schwartz ,  Ruth Arnon ,  Rina Aharoni

IPC分类号： A61K38/17 ,  A61K31/5415 ,  A61K31/4745 ,  C07K14/705

CPC分类号： C07K14/001 ,  A61K38/02

摘要： The invention provides a composition comprising a mixture of polypeptides, wherein each polypeptide (a) is a copolymer of the amino acids L-glutamic acid, L-alanine, L-tyrosine, and L-lysine, and (b) may be in the form of a pharmaceutically acceptable salt; and wherein in the mixture (i) the polypeptides have an average molecular weight in the range 13,500 to 18,500 daltons, (ii) 13% to 38% of the polypeptides have a diethylamide group instead of a carboxyl group present at one end thereof, and (iii) 68% of the polypeptides have a molecular weight between 7,000 and 41,000 daltons. In an embodiment, the average molecular weight is 16,000 daltons, and processes for preparing and its uses.

摘要翻译： 本发明提供包含多肽混合物的组合物，其中每个多肽（a）是L-谷氨酸，L-丙氨酸，L-酪氨酸和L-赖氨酸的氨基酸的共聚物，和（b）可以在 形式的药学上可接受的盐; 并且其中在所述混合物（i）中，所述多肽的平均分子量范围为13,500至18,500道尔顿，（ii）13％至38％的多肽具有二乙酰胺基而不是存在于其一端的羧基，以及 （iii）68％的多肽具有7,000至41,000道尔顿的分子量。 在一个实施方案中，平均分子量为16,000道尔顿，其制备及其用途的方法。

公开(公告)号：US07560100B2

公开(公告)日：2009-07-14

申请号：US11223408

申请日：2005-09-09

申请人： Irit Pinchasi ,  Ben-Zion Dolitzky ,  Anton Frenkel ,  Michal Schwartz ,  Ruth Arnon ,  Rina Aharoni

发明人： Irit Pinchasi ,  Ben-Zion Dolitzky ,  Anton Frenkel ,  Michal Schwartz ,  Ruth Arnon ,  Rina Aharoni

IPC分类号： A61K31/74

CPC分类号： C07K14/001 ,  A61K38/02

摘要： The invention provides a composition comprising a mixture of polypeptides, wherein each polypeptide (a) is a copolymer of the amino acids L-glutamic acid, L-alanine, L-tyrosine, and L-lysine, and (b) may be in the form of a pharmaceutically acceptable salt; and wherein in the mixture (i) the polypeptides have an average molecular weight in the range 13,500 to 18,500 daltons, (ii) 13% to 38% of the polypeptides have a diethylamide group instead of a carboxyl group present at one end thereof, and (iii) 68% of the polypeptides have a molecular weight between 7,000 and 41,000 daltons. In an embodiment, the average molecular weight is 16,000 daltons. The invention also provides a method of treating a human subject afflicted with a neurodegenerative disease comprising administering to the human subject a therapeutically effective amount of any of the disclosed compositions so as to thereby treat the human subject.

摘要翻译： 本发明提供包含多肽混合物的组合物，其中每个多肽（a）是L-谷氨酸，L-丙氨酸，L-酪氨酸和L-赖氨酸的氨基酸的共聚物，和（b）可以在 形式的药学上可接受的盐; 并且其中在所述混合物（i）中，所述多肽的平均分子量范围为13,500至18,500道尔顿，（ii）13％至38％的多肽具有二乙酰胺基团而不是存在于其一端的羧基，以及 （iii）68％的多肽具有7,000至41,000道尔顿的分子量。 在一个实施方式中，平均分子量为16,000道尔顿。 本发明还提供了治疗患有神经变性疾病的人类受试者的方法，包括向人类受试者施用治疗有效量的任何所公开的组合物，从而治疗人受试者。

公开(公告)号：US20070054857A1

公开(公告)日：2007-03-08

申请号：US11541263

申请日：2006-09-29

申请人： Irit Pinchasi ,  Ben-Zion Dolitzky ,  Anton Frenkel ,  Michal Schwartz ,  Ruth Arnon ,  Rina Aharoni

发明人： Irit Pinchasi ,  Ben-Zion Dolitzky ,  Anton Frenkel ,  Michal Schwartz ,  Ruth Arnon ,  Rina Aharoni

IPC分类号： A61K38/16

CPC分类号： C07K14/001 ,  A61K38/02

摘要： The invention provides a composition comprising a mixture of polypeptides, wherein each polypeptide (a) is a copolymer of the amino acids L-glutamic acid, L-alanine, L-tyrosine, and L-lysine, and (b) may be in the form of a pharmaceutically acceptable salt; and wherein in the mixture (i) the polypeptides have an average molecular weight in the range 13,500 to 18,500 daltons, (ii) 13% to 38% of the polypeptides have a diethylamide group instead of a carboxyl group present at one end thereof, and (iii) 68% of the polypeptides have a molecular weight between 7,000 and 41,000 daltons. In an embodiment, the average molecular weight is 16,000 daltons, and processes for preparing and its uses.

摘要翻译： 本发明提供包含多肽混合物的组合物，其中每个多肽（a）是L-谷氨酸，L-丙氨酸，L-酪氨酸和L-赖氨酸的氨基酸的共聚物，和（b）可以在 形式的药学上可接受的盐; 并且其中在所述混合物（i）中，所述多肽的平均分子量范围为13,500至18,500道尔顿，（ii）13％至38％的多肽具有二乙酰胺基团而不是存在于其一端的羧基，以及 （iii）68％的多肽具有7,000至41,000道尔顿的分子量。 在一个实施方案中，平均分子量为16,000道尔顿，其制备及其用途的方法。

公开(公告)号：US20110286932A1

公开(公告)日：2011-11-24

申请号：US13119596

申请日：2009-09-18

申请人： Yosef Koronyo ,  Maya Koronyo ,  Keith L. Black ,  Michal Schwartz ,  Daniel L. Farkas

发明人： Yosef Koronyo ,  Maya Koronyo ,  Keith L. Black ,  Michal Schwartz ,  Daniel L. Farkas

IPC分类号： A61K49/00 ,  A61P27/06 ,  A61P27/02 ,  A61K39/00 ,  A61P25/28

CPC分类号： A61K49/0021 ,  A61K49/006

摘要： The present subject matter relates to a non-invasive optical imaging method for monitoring early pathological events specific to Alzheimer's disease (AD), such as the development, amount and location of amyloid plaques. The ability to monitor such events provides a basis for, among other things, AD diagnosis, prognosis and assessment of potential therapies. In addition, the present subject matter introduces novel methods for treating AD and retinal ailments associated with AD. Aβ-plaque detection in living brains is extremely limited, especially at high resolution; therefore the present invention is based on studies focusing on the eyes as an alternative to brain-derived tissue that can be imaged directly, repetitively and non-invasively.

摘要翻译： 本发明涉及用于监测阿尔茨海默氏病（AD）特异性的早期病理学事件的非侵入性光学成像方法，例如淀粉样蛋白斑块的发育，数量和位置。 监测此类事件的能力为AD诊断，预后和潜在疗法评估提供了依据。 此外，本主题介绍了治疗与AD相关的AD和视网膜疾病的新方法。 活体大脑中的斑块检测非常有限，特别是在高分辨率下; 因此，本发明基于将眼睛作为可以直接，重复和非侵入地成像的脑源性组织的替代物的研究。

公开(公告)号：US20230385877A1

公开(公告)日：2023-11-30

申请号：US18323312

申请日：2023-05-24

申请人： David Philip Miller ,  Michal Schwartz

发明人： David Philip Miller ,  Michal Schwartz

IPC分类号： G06Q30/0251 ,  G06Q30/02 ,  B65D23/00

CPC分类号： G06Q30/0261 ,  G06Q30/0269 ,  B65D23/00 ,  G06Q30/02

摘要： A system and a method for controlling an electronic device embedded in a package of a consumer product are disclosed. In one aspect, the consumer product packaging includes a bottle for a beverage, a memory, a receiver and a circuit. The memory stores an action to be performed in response to an input. The receiver receives the input indicative of movement of the bottle. The circuit retrieves the action stored in memory upon receipt of the input and command an electronic communication module to perform the action at a particular time or in a particular sequence.

公开(公告)号：US11200600B2

公开(公告)日：2021-12-14

申请号：US14592794

申请日：2015-01-08

申请人： David Philip Miller ,  Michal Schwartz

发明人： David Philip Miller ,  Michal Schwartz

IPC分类号： G06Q30/00 ,  G06Q30/02 ,  B65D23/00

摘要： A system and a method for controlling an electronic device embedded in a package of a consumer product are disclosed. In one aspect, the consumer product packaging includes a bottle for a beverage, a memory, a receiver and a circuit. The memory stores an action to be performed in response to an input. The receiver receives the input indicative of movement of the bottle. The circuit retrieves the action stored in memory upon receipt of the input and command an electronic communication module to perform the action at a particular time or in a particular sequence.

公开(公告)号：US20190022255A1

公开(公告)日：2019-01-24

申请号：US15798612

申请日：2017-10-31

申请人： Yosef Koronyo ,  Maya Koronyo ,  Keith Black ,  Michal Schwartz ,  Daniel L. Farkas

发明人： Yosef Koronyo ,  Maya Koronyo ,  Keith Black ,  Michal Schwartz ,  Daniel L. Farkas

IPC分类号： A61K49/00

摘要： The present subject matter relates to a non-invasive optical imaging method for monitoring early pathological events specific to Alzheimer's disease (AD), such as the development, amount and location of amyloid plaques. The ability to monitor such events provides a basis for, among other things, AD diagnosis, prognosis and assessment of potential therapies. In addition, the present subject matter introduces novel methods for treating AD and retinal ailments associated with AD. Aβ-plaque detection in living brains is extremely limited, especially at high resolution; therefore the present invention is based on studies focusing on the eyes as an alternative to brain-derived tissue that can be imaged directly, repetitively and non-invasively.

公开(公告)号：US20130060821A1

公开(公告)日：2013-03-07

申请号：US13604302

申请日：2012-09-05

申请人： David Miller ,  Michal Schwartz

发明人： David Miller ,  Michal Schwartz

IPC分类号： G06F17/30

CPC分类号： G06Q30/0261 ,  B65D23/00 ,  G06Q30/02 ,  G06Q30/0269

摘要： Systems, methods and apparatus are disclosed for database generation of synchronized actions. In one aspect a method is provided for generating a database of data items indicative of synchronized actions. The method includes determining a set of devices for execution of a storyboard. The set of devices includes packaging of a consumer product. The storyboard relates to promotion of the consumer product. The method further includes generating the storyboard. The storyboard includes a set of actions for the devices. The storyboard includes a set of interrelated actions that form a message for communication to an audience. The method further includes generating data items. The data items correspond to the actions of the storyboard. At least a portion of the data items include time synchronization information for the set of actions. The method further includes storing the data items and the time synchronization information relating to the storyboard in the database.

摘要翻译： 公开了用于同步动作的数据库生成的系统，方法和装置。 在一个方面，提供了一种用于生成指示同步动作的数据项的数据库的方法。 该方法包括确定用于执行故事板的一组设备。 该组装置包括消费品的包装。 故事板涉及促销消费品。 该方法还包括生成故事板。 故事板包括一组针对设备的动作。 故事板包括一组相互关联的动作，形成与观众沟通的讯息。 该方法还包括生成数据项。 数据项对应于故事板的动作。 数据项的至少一部分包括该组动作的时间同步信息。 该方法还包括将与故事板相关的数据项和时间同步信息存储在数据库中。

公开(公告)号：US09839699B2

公开(公告)日：2017-12-12

申请号：US13119596

申请日：2009-09-18

申请人： Yosef Koronyo ,  Maya Koronyo ,  Keith L. Black ,  Michal Schwartz ,  Daniel L. Farkas

发明人： Yosef Koronyo ,  Maya Koronyo ,  Keith L. Black ,  Michal Schwartz ,  Daniel L. Farkas

IPC分类号： A61B5/00 ,  A61B3/00 ,  A61B6/00 ,  A61K49/00

CPC分类号： A61K49/0021 ,  A61K49/006

摘要： The present subject matter relates to a non-invasive optical imaging method for monitoring early pathological events specific to Alzheimer's disease (AD), such as the development, amount and location of amyloid plaques. The ability to monitor such events provides a basis for, among other things, AD diagnosis, prognosis and assessment of potential therapies. In addition, the present subject matter introduces novel methods for treating AD and retinal ailments associated with AD. Aβ-plaque detection in living brains is extremely limited, especially at high resolution; therefore the present invention is based on studies focusing on the eyes as an alternative to brain-derived tissue that can be imaged directly, repetitively and non-invasively.

公开(公告)号：US20150120457A1

公开(公告)日：2015-04-30

申请号：US14592794

申请日：2015-01-08

申请人： David Philip Miller ,  Michal Schwartz

发明人： David Philip Miller ,  Michal Schwartz

IPC分类号： G06Q30/02 ,  B65D23/00

CPC分类号： G06Q30/0261 ,  B65D23/00 ,  G06Q30/02 ,  G06Q30/0269

摘要： A system and a method for controlling an electronic device embedded in a package of a consumer product are disclosed. In one aspect, the consumer product packaging includes a bottle for a beverage, a memory, a receiver and a circuit. The memory stores an action to be performed in response to an input. The receiver receives the input indicative of movement of the bottle. The circuit retrieves the action stored in memory upon receipt of the input and command an electronic communication module to perform the action at a particular time or in a particular sequence.

摘要翻译： 公开了一种用于控制嵌入在消费品的包装中的电子设备的系统和方法。 一方面，消费品包装包括用于饮料的瓶子，存储器，接收器和电路。 存储器存储响应于输入而被执行的动作。 接收器接收指示瓶子运动的输入。 电路在接收到输入并检索电子通信模块时检索存储在存储器中的动作，以在特定时间或特定顺序执行动作。