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公开(公告)号：US20190022255A1
公开(公告)日：2019-01-24
申请号：US15798612
申请日：2017-10-31
申请人： Yosef Koronyo , Maya Koronyo , Keith Black , Michal Schwartz , Daniel L. Farkas
发明人： Yosef Koronyo , Maya Koronyo , Keith Black , Michal Schwartz , Daniel L. Farkas
IPC分类号： A61K49/00
摘要： The present subject matter relates to a non-invasive optical imaging method for monitoring early pathological events specific to Alzheimer's disease (AD), such as the development, amount and location of amyloid plaques. The ability to monitor such events provides a basis for, among other things, AD diagnosis, prognosis and assessment of potential therapies. In addition, the present subject matter introduces novel methods for treating AD and retinal ailments associated with AD. Aβ-plaque detection in living brains is extremely limited, especially at high resolution; therefore the present invention is based on studies focusing on the eyes as an alternative to brain-derived tissue that can be imaged directly, repetitively and non-invasively.
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公开(公告)号：US20110286932A1
公开(公告)日：2011-11-24
申请号：US13119596
申请日：2009-09-18
CPC分类号： A61K49/0021 , A61K49/006
摘要： The present subject matter relates to a non-invasive optical imaging method for monitoring early pathological events specific to Alzheimer's disease (AD), such as the development, amount and location of amyloid plaques. The ability to monitor such events provides a basis for, among other things, AD diagnosis, prognosis and assessment of potential therapies. In addition, the present subject matter introduces novel methods for treating AD and retinal ailments associated with AD. Aβ-plaque detection in living brains is extremely limited, especially at high resolution; therefore the present invention is based on studies focusing on the eyes as an alternative to brain-derived tissue that can be imaged directly, repetitively and non-invasively.
摘要翻译： 本发明涉及用于监测阿尔茨海默氏病（AD）特异性的早期病理学事件的非侵入性光学成像方法，例如淀粉样蛋白斑块的发育，数量和位置。 监测此类事件的能力为AD诊断，预后和潜在疗法评估提供了依据。 此外，本主题介绍了治疗与AD相关的AD和视网膜疾病的新方法。 活体大脑中的斑块检测非常有限，特别是在高分辨率下; 因此，本发明基于将眼睛作为可以直接，重复和非侵入地成像的脑源性组织的替代物的研究。
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公开(公告)号：US09839699B2
公开(公告)日：2017-12-12
申请号：US13119596
申请日：2009-09-18
CPC分类号： A61K49/0021 , A61K49/006
摘要： The present subject matter relates to a non-invasive optical imaging method for monitoring early pathological events specific to Alzheimer's disease (AD), such as the development, amount and location of amyloid plaques. The ability to monitor such events provides a basis for, among other things, AD diagnosis, prognosis and assessment of potential therapies. In addition, the present subject matter introduces novel methods for treating AD and retinal ailments associated with AD. Aβ-plaque detection in living brains is extremely limited, especially at high resolution; therefore the present invention is based on studies focusing on the eyes as an alternative to brain-derived tissue that can be imaged directly, repetitively and non-invasively.
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公开(公告)号：US20130295062A1
公开(公告)日：2013-11-07
申请号：US13979610
申请日：2012-01-18
IPC分类号： A61K38/48
CPC分类号： A61K38/4813 , A61K35/15 , A61K35/30 , C12N5/10
摘要： The present invention relates to methods and compositions for use in the treatment of neurological disorders, such as Alzheimer's disease and dementia. In one embodiment, the present invention provides a method of treatment of Alzheimer's disease in an individual by administering a composition overexpressing ACE to the individual. In another embodiment, the method of treatment comprises administering a composition comprising a therapeutically effective dosage of ACE.
摘要翻译： 本发明涉及用于治疗诸如阿尔茨海默病和痴呆的神经障碍的方法和组合物。 在一个实施方案中，本发明提供了通过向个体施用过表达ACE的组合物来治疗个体中阿尔茨海默病的方法。 在另一个实施方案中，治疗方法包括施用包含治疗有效剂量的ACE的组合物。
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