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公开(公告)号:US20100272641A1
公开(公告)日:2010-10-28
申请号:US12430573
申请日:2009-04-27
申请人: JACK MATHEW WEBSTER , FAISAL AHMED SYUD , BRIAN DUH-LAN LEE , PAUL SCHAFFER , RONG ZHANG , JENNIFER LYNNE HUNTINGTON , KANDE KANKANAMALAGE DAYARATHNA AMARASINGHE
发明人: JACK MATHEW WEBSTER , FAISAL AHMED SYUD , BRIAN DUH-LAN LEE , PAUL SCHAFFER , RONG ZHANG , JENNIFER LYNNE HUNTINGTON , KANDE KANKANAMALAGE DAYARATHNA AMARASINGHE
IPC分类号: A61K51/04 , C07C321/00 , C07F5/02
CPC分类号: A61K51/0406 , A61K49/0019 , A61K49/0052 , C07B59/001 , C07B2200/05 , C07C323/58 , C07C323/59 , C07F5/022
摘要: Imaging agents that comprise labeled substrates of the cystine/glutamate antiporter of cells, whereby the methods of use comprise introducing the labeled agents into cells via the cystine/glutamate antiporter, which are then reduced to a labeled cysteine, and subsequently detected in the cell.
摘要翻译: 包含细胞的胱氨酸/谷氨酸反转录酶的标记底物的成像剂,其中使用的方法包括将经标记的试剂通过胱氨酸/谷氨酸反转运体引入细胞,然后将其还原成标记的半胱氨酸,随后在细胞中检测。