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    SUPER-RESOLUTION FLUORESCENT IMAGING PROBE
    6.
    发明申请
    SUPER-RESOLUTION FLUORESCENT IMAGING PROBE 审中-公开

    公开(公告)号：US20180052109A1

    公开(公告)日：2018-02-22

    申请号：US15551149

    申请日：2016-02-23

    申请人： The University of Tokyo

    发明人： Yasuteru URANO ,  Mako KAMIYA ,  Akihiko MOROZUMI ,  Shinnosuke UNO ,  Keitaro UMEZAWA

    IPC分类号： G01N21/64 ,  A61K49/00 ,  C09K11/06

    CPC分类号： G01N21/6458 ,  A61K49/0019 ,  A61K49/005 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1029 ,  C09K2211/1074 ,  C09K2211/1096 ,  G01N21/6428 ,  G01N33/533 ,  G01N33/68 ,  G01N2021/6439 ,  G02B21/0076 ,  G02B27/58

    摘要： [Problem] To provide a novel fluorescent probe for super-resolution imaging that uses fluorescent light emission characteristics that originate from an intermolecular nucleophilic addition-dissociation equilibrium reaction, and to provide a super-resolution fluorescent imaging method that uses the probe. [Solution] A fluorescent probe for super-resolution imaging that comprises a compound represented by formula (I) or a salt thereof(in the formula, X represents an oxygen atom, C(Ra) (Rb), or Si(Ra) (Rb) (wherein Ra and Rb each independently represent a hydrogen atom or an alkyl group), R1 represents a hydrogen atom or an optionally substituted aryl (provided that, if R1 is a phenyl group, the benzene ring of the phenyl group does not have a substituent at position 2 or position 6), R2 and R3 each independently represent 1-3 identical or differing substituents that are independently selected from the group that consists of hydrogen atoms, hydroxyl groups, halogen atoms, optionally substituted alkyl groups, optionally substituted sulfo groups, optionally substituted carboxyl groups, optionally substituted ester groups, optionally substituted amide groups, and optionally substituted azide groups, R4 and R5 each independently represent a hydrogen atom or an optionally substituted alkyl group or N(R4) (R5) forms an amide group or a carbamate group (provided that, if R4 or R5 is an alkyl group, each may form, together with R2, a ring structure that contains the nitrogen atom that is bonded thereto), and R6 and R7 each independently represent a hydrogen atom or an optionally substituted alkyl group or N(R6)(R7) forms an amide group or a carbamate group (provided that, if R6 or R7 is an alkyl group, each may form, together with R3, a ring structure that contains the nitrogen atom that is bonded thereto)), the fluorescent probe for super-resolution imaging being characterized in that the compound represented by formula (I) or the salt thereof undergoes a nucleophilic addition-dissociation equilibrium reaction with a nucleophilic compound that contains an —SH group.