公开(公告)号：US11597725B2

公开(公告)日：2023-03-07

申请号：US16617426

申请日：2018-05-25

Applicant: JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO., LTD.

Inventor： Dongfang Shi ,  Jianghua Zhu ,  Jie Gu ,  Xi Cheng ,  Yan Yang ,  He Zhou ,  Pengfei Li ,  Fan Wu

IPC: C07D471/04 ,  A61P19/06 ,  C07D231/56 ,  C07D487/04 ,  C07D491/052

Abstract: The present invention belongs to the field of medicinal chemistry. Specifically disclosed is a class of URAT1 inhibitors for promoting uric acid excretion, which are compounds as represented by the structure of formula (I) or pharmaceutically acceptable salts thereof. Experiments show that the compounds provided by the present invention have a very good inhibitory effect on the transport of uric acid by hURAT1 in HEK293 transfected cells, and that such compounds have a good application prospect in the treatment of hyperuricemia or gout.