公开(公告)号：US11136408B2

公开(公告)日：2021-10-05

申请号：US16095800

申请日：2017-07-04

Applicant: JOINT STOCK COMPANY “BIOCAD”

Inventor： Viktoriia Mikhailovna Ekimova ,  Dmitry Valeryevich Korzhavin ,  Yulia Sergeevna Chernykh ,  Timofey Aleksandrovich Nemankin ,  Valery Vladimirovich Solovyev ,  Anna Konstantinovna Vladimirova ,  Irina Andreevna Bulankina ,  Sergei Vasilyevich Diduk ,  Olga Vladimirovna Goncharova ,  Anna Vladimirovna Eroshova ,  Iakov Lurevich Ustiugov ,  Marina Vladimirovna Artiukhova ,  Andrei Borisovich Ulitin ,  Roman Alekseevich Ivanov ,  Dmitry Valentinovich Morozov

IPC: A61K39/00 ,  C07K16/28 ,  C12N15/63 ,  A61K39/395 ,  A61P31/00 ,  A61P35/00

Abstract: The present invention relates to biotechnology and comprises isolated monoclonal antibodies, in particular human monoclonal antibodies, which specifically bind to PD-1 with high affinity. The antibodies according to the invention may be chimeric, humanized or human antibodies, or antigen-binding fragments thereof, and may be used as a medicinal agent in oncology and immuno-oncology, for treating diseases associated with various cell proliferation or development disorders. The invention also relates to methods for producing said antibodies and a method for treating human diseases using said antibodies.