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公开(公告)号：US11840567B2
公开(公告)日：2023-12-12
申请号：US16753587
申请日：2018-10-03
Applicant: JOINT STOCK COMPANY “BIOCAD”
Inventor： Kirill Vladimirovich Solovyev , Andrei Borisovich Ulitin , Timofey Aleksandrovich Nemankin , Valery Vladimirovich Solovyev , Dmitry Valentinovich Morozov
IPC: C07K16/28
CPC classification number: C07K16/2803 , C07K16/2827 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to the field of bioengineering, specifically to antibodies or their antigen-binding fragments, and to the use thereof. More particularly, the present invention relates to antibodies that bind specifically to CD47 and PD-L1. The invention also relates to a nucleic acid that codes for the given antibody or for the antigen-binding fragment thereof, to an expression vector, to a method of producing the antibody, and to a use of the aforementioned antibodies and compositions in cancer treatment.
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公开(公告)号：US12202906B2
公开(公告)日：2025-01-21
申请号：US17288234
申请日：2019-10-30
Applicant: JOINT STOCK COMPANY “BIOCAD”
Inventor： Pavel Andreevich Iakovlev , Natalia Eugenievna Pestova , Arina Vitalevna Anikina , Anna Alexandrovna Trudovishnikova , Mariia Aleksandrovna Shchemeleva , Nina Grachyaevna Kharatian , Valery Vladimirovich Solovyev , Alexey Konstantinovich Misorin , Sergei Vasilyevich Diduk , Anna Vladimirovna Eroshova , Veronika Sergeevna Usatova , Elena Andreevna Krendeleva , Iakov Iurevich Ustiugov , Aleksei Aleksandrovich Aleksandrov , Iana Andreevna Smirnova , Svetlana Vladimirovna Koskova , Roman Alekseevich Ivanov , Dmitry Valentinovich Morozov
IPC: A61K39/395 , A61P35/02 , C07K16/28 , C12N15/63 , A61K39/00
Abstract: The present invention relates to biotechnology and provides a monoclonal antibody that specifically binds to CD20. The invention also relates to DNA encoding said antibody, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using said antibody.
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公开(公告)号：US11993647B2
公开(公告)日：2024-05-28
申请号：US16325528
申请日：2017-08-03
Applicant: JOINT STOCK COMPANY “BIOCAD”
Inventor： Stanislav Rudolfovich Evdokimov , Andrei Borisovich Ulitin , Valery Vladimirovich Solovyev , Aleksei Aleksandrovich Aleksandrov , Yulia Sergeevna Chernykh , Timofey Aleksandrovich Nemankin , Anna Konstantinovna Vladimirova , Oleg Igorevich Smotrov , Tatiana Veniaminovna Chernovskaya , Aleksandr Aleksandrovich Moshchenko , Viktoriia Evgenevna Nalobina , Roman Alekseevich Ivanov , Dmitry Valentinovich Morozov
IPC: C07K16/24 , A61K9/00 , A61K9/19 , A61K39/395 , A61P37/00 , A61P37/06 , A61P37/08 , C07K16/06 , C07K16/18 , C12N15/00 , C12N15/63
CPC classification number: C07K16/248 , A61K9/0073 , A61K9/19 , A61K39/395 , A61P37/00 , A61P37/06 , A61P37/08 , C07K16/065 , C07K16/18 , C07K16/24 , C12N15/00 , C12N15/63
Abstract: The invention relates to medicine. The problem addressed by the present invention consists in creating alternative antibodies or fragments thereof which are capable of specifically binding to a human receptor of interleukin-6 and which would be useful as drugs for treating or diagnosing diseases, or for relieving symptoms, mediated by interleukin-6.
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公开(公告)号：US11840531B2
公开(公告)日：2023-12-12
申请号：US17264670
申请日：2019-07-31
Applicant: JOINT STOCK COMPANY “BIOCAD”
Inventor： Aleksei Leonidovich Mindich , Anna Jur'evna Chestnova , Mariia Andreevna Kasatkina , Andrei Ivanovich Alafinov , Aleksei Sergeevich Gavrilov , Anton Aleksandrovich Evdokimov , Liliana Vyacheslavovna Lenshmidt , Elena Aleksandrovna Maksimenko , Mariia Sergeevna Mishina , Sergei Aleksandrovich Silonov , Evgenii Jur'evich Smirnov , Pavel Andreevich Iakovlev , Dmitry Valentinovich Morozov
IPC: C07D471/04 , A61P35/00 , A61K31/4375
CPC classification number: C07D471/04 , A61K31/4375 , A61P35/00
Abstract: The present invention relates to novel compounds of formula I:
which have the properties of CDK8/19 inhibitors, to a pharmaceutical composition comprising said compounds, and to use thereof as a medicine for treating diseases and disorders.-
公开(公告)号：US12297269B2
公开(公告)日：2025-05-13
申请号：US17417570
申请日：2019-12-24
Applicant: JOINT STOCK COMPANY “BIOCAD”
Inventor： Olga Vladimirovna Britanova , Dmitry Borisovich Staroverov , Anna Valentinovna Evstrateva , Alexey Konstantinovich Misorin , Timofey Aleksandrovich Nemankin , Mariia Aleksandrovna Shchemeleva , Anna Konstantinovna Vladimirova , Arina Vitalevna Anikina , Roman Alekseevich Ivanov , Dmitry Valentinovich Morozov , Pavel Andreevich Iakovlev , Sergey Anatolievich Lukyanov
IPC: C07K16/28 , A61K39/00 , A61K39/395 , A61K45/06
Abstract: A monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. A nucleic acid encoding the antibody or antigen-binding fragment thereof, an expression vector, a method for preparing the antibody, and use of the antibody in treatment of diseases or disorders associated with the human T cell receptor family. The generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs.
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Patent Agency Ranking
公开(公告)号：US12173336B2
公开(公告)日：2024-12-24
申请号：US17276016
申请日：2019-09-13
Applicant: JOINT STOCK COMPANY “BIOCAD”
Inventor： Dmitriy Aleksandrovich Madera , Aleksandr Vladimirovich Karabelskii , Roman Alekseevich Ivanov , Dmitry Valentinovich Morozov , Konstantin Viktorovich Severinov , Sergey Anatolevich Shmakov , Dmitrii Aleksandrovich Sutormin , Georgii Evgenevich Pobegalov , Aleksandra Andreevna Vasileva , Polina Anatolevna Selkova , Anatolii Nikolaevich Arseniev , Tatyana Igorevna Zyubko , Iana Vitalevna Fedorova
Abstract: The present invention relates to the field of biotechnology, molecular biology and medicine, in particular to nuclease enzyme and use thereof. More specifically, the present invention relates to PaCas9 nuclease enzyme. The invention also relates to a nucleic acid encoding the nuclease, a genetic construct, an expression vector, a delivery vector, which comprise the nucleic acid, a liposome comprising the nuclease or nucleic acid encoding the nuclease, a method for producing a nuclease, methods for delivery, and a host cell comprising a nucleic acid encoding the nuclease.
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公开(公告)号：US11236167B2
公开(公告)日：2022-02-01
申请号：US16605865
申请日：2018-04-11
Applicant: JOINT STOCK COMPANY “BIOCAD”
Inventor： Andrei Borisovich Ulitin , Viktoriia Mikhailovna Ekimova , Ekaterina Vladimirovna Sofronova , Yulia Sergeevna Chernykh , Sergei Andreevich Ageev , Anna Konstantinovna Vladimirova , Aleksei Aleksandrovich Aleksandrov , Pavel Alekseevich Grebnev , Valery Vladimirovich Solovyev , Iakov Iurevich Ustiugov , Pavel Andreevich Iakovlev , Timofey Aleksandrovich Nemankin , Dmitry Valentinovich Morozov
IPC: C07K16/28 , A61K39/395 , A61K45/06
Abstract: The present invention relates to the field of biotechnology and provides antibodies that specifically binds to PD-L1. The invention also relates to DNA encoding said antibodies, to corresponding expression vectors and to methods of producing, and to methods of treatment using said antibodies.
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公开(公告)号：US12227572B2
公开(公告)日：2025-02-18
申请号：US17417686
申请日：2020-02-20
Applicant: JOINT STOCK COMPANY “BIOCAD”
Inventor： Olga Vladimirovna Britanova , Dmitry Borisovich Staroverov , Anna Valentinovna Evstrateva , Alexey Konstantinovich Misorin , Timofey Aleksandrovich Nemankin , Mariia Aleksandrovna Shchemeleva , Anna Konstantinovna Vladimirova , Arina Vitalevna Anikina , Roman Alekseevich Ivanov , Dmitry Valentinovich Morozov , Pavel Andreevich Iakovlev , Sergey Anatolievich Lukyanov
Abstract: The invention relates to a monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs.
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公开(公告)号：US12173075B2
公开(公告)日：2024-12-24
申请号：US16753488
申请日：2018-10-02
Applicant: JOINT STOCK COMPANY “BIOCAD”
Inventor： Ekaterina Vladimirovna Sofronova , Aleksei Konstantinovich Misorin , Aleksandr Nikolaevich Doronin , Timofey Aleksandrovich Nemankin , Aleksandra Aleksandrovna Sozonova , Galina Stepanovna Zhirivskaia , Sergey Aleksandrovich Legotsky , Anna Konstantinovna Vladimirova , Alina Valerevna Beliasnikova , Mariia Aleksandrovna Shchemeleva , Pavel Andreevich Iakovlev , Valery Vladimirovich Solovyev , Elena Andreevna Krendeleva , Natalia Evgenevna Pestova , Dmitry Valentinovich Morozov
Abstract: The present disclosure relates to biotechnology and provides antibodies that specifically bind to IL-5Rα. The disclosure also relates to DNA encoding the antibodies, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using the antibodies.
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公开(公告)号：US11453717B2
公开(公告)日：2022-09-27
申请号：US16097562
申请日：2016-12-02
Applicant: JOINT STOCK COMPANY “BIOCAD”
Inventor： Dmitry Valentinovich Morozov , Andrei Borisovich Ulitin , Ekaterina Sergeevna Zubareva , Iakov Iurevich Ustiugov , Aleksandr Vladimirovich Karabelskii , Dmitry Valeryevich Korzhavin , Tatiana Veniaminovna Chernovskaya , Aleksandr Valerevich Grachev , Yury Ivanovich Basovskiy , Ekaterina Aleksandrovna Lomkova , Veronika Sergeevna Usatova , Aleksei Aleksandrovich Aleksandrov , Elena Leonidovna Morozova , Roman Alekseevich Ivanov , Pavel Andreevich Iakovlev
IPC: C07K16/24 , A61K39/395 , A61P19/02 , A61K45/06 , A61K39/00
Abstract: The present invention relates to the field of biotechnology and provides monoclonal tri-specific binding molecules that specifically bind to human IL-17A, human IL-17F, and a human pro-inflammatory molecule (in particular, TNFα) with high affinity. The invention also relates to DNA constructs encoding said binding molecules, related expression vectors and methods of production, and methods of treatment using said binding molecules.
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