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    Cephalosporins
    2.
    发明授权
    Cephalosporins 失效
    头孢菌素

    公开(公告)号：US06313305B1

    公开(公告)日：2001-11-06

    申请号：US08900366

    申请日：1997-07-21

    申请人： Jozsef Aszodi ,  Jean-Francois Chantot ,  Patrick Fauveau ,  Solange Gouin d'Ambrieres ,  Daniel Humbert ,  Christophe Dini

    发明人： Jozsef Aszodi ,  Jean-Francois Chantot ,  Patrick Fauveau ,  Solange Gouin d'Ambrieres ,  Daniel Humbert ,  Christophe Dini

    IPC分类号： C07D28508

    CPC分类号： C07D501/00 ,  C07C45/63 ,  C07C45/673 ,  C07C45/71 ,  C07C47/565 ,  C07C47/575 ,  C07C59/64 ,  C07C69/734 ,  C07C205/44 ,  C07C239/20 ,  C07C255/56 ,  C07C255/57 ,  Y02P20/55

    摘要： A compound having the formula selected from the group consisting of wherein either R3p and R4p are identical and selected from the group consisting of —OH, protected —OH and acyloxy of 1 to 8 carbon atoms, R2p is selected from the group consisting of —CN, —F, Br and I and R1p and R5p are hydrogen or R5p is —F and R1p and R2p are hydrogen or R1p and R2p are F and R5p is hydrogen, or R4p and R5p are identical and selected from the group consisting of —OH, protected —OH and acyloxy of 1 to 8 carbon atoms, R3p is selected from the group consisting of F and —CN and R1p and R2p are hydrogen, R8 is hydrogen or an amine protective group and R10 is the remainder in which the hydroxy or amino are protected wherein R′1 is selected from the group consisting of alkyl of 1 to 4 carbon atoms, —CN, carboxy and alkoxy carbonyl of 1 to 4 carbon atoms.

    摘要翻译： 具有选自R3p和R4p中的式的化合物是相同的，并且选自-OH，被保护的-OH和1至8个碳原子的酰氧基，R2p选自-CN， -F，Br和I，R1p和R5p是氢或R5p是-F，R1p和R2p是氢或R1p，R2p是F，R5p是氢，或R4p和R5p是相同的，选自-OH， 保护的-OH和1至8个碳原子的酰氧基，R3p选自F和-CN，R1p和R2p是氢，R8是氢或胺保护基，R10是其中羟基或氨基 被保护，其中R'1选自1至4个碳原子的烷基，-CN，羧基和1至4个碳原子的烷氧基羰基。

    Cephalosporins
    9.
    发明授权
    Cephalosporins 失效
    头孢菌素

    公开(公告)号：US5936083A

    公开(公告)日：1999-08-10

    申请号：US625910

    申请日：1996-04-01

    申请人： Jozsef Aszodi ,  Jean-Francois Chantot ,  Solange Gouin D'Ambrieres

    发明人： Jozsef Aszodi ,  Jean-Francois Chantot ,  Solange Gouin D'Ambrieres

    IPC分类号： C07D501/00 ,  C07D501/22 ,  C07D501/24 ,  C07D501/56

    CPC分类号： C07D501/00

    摘要： A compound selected from the group consisting of a syn isomer of a compound of the formula ##STR1## in the R or S form or in the form of an R, S mixture wherein R us selected from the group consisting of ##STR2## R and R' are individually selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, CO.sub.2 --Q, ##STR3## CH.sub.2 --SQ, Q and Q' are individually hydrogen or alkyl of 1 to 4 carbon atoms, P, P' and P" are individually alkyl of 1 to 4 carbon atoms optionally substituted by one of the substituents R and R' the dotted line indicating that P and P' can optionally form with the nitrogen atom to which they are linked a heterocycle with 5 or 6 links, R.sub.b and R.sub.c are individually selected from the group consisting of an equivalent of an alkali metal, an alkaline earth metal, magnesium, ammonium and an amine organic base or A and A' are the remainder of an easily cleavable ester group or CO.sub.2 A is CO.sub.2 --and the wavy line indicates that CH.sub.2 R.sub.1 is in the E or Z position and their non-toxic, pharmaceutically acceptable acid addition salts having anti-bacterial activity.

    摘要翻译： 选自R或S形式的式的化合物的顺式异构体或R，S混合物形式的化合物，其中R us选自R和R'的化合物分别选自 由氢，1-4个碳原子的烷基，1-4个碳原子的烷氧基，卤素，CO2-Q，CH2-SQ，Q和Q'分别是氢或1-4个碳原子的烷基，P， P'和P“分别是1至4个碳原子的烷基，任选被一个取代基R和R'取代，虚线表示P和P'可以任选地与它们连接的氮原子一起形成杂环与 5或6链，Rb和Rc分别选自碱金属，碱土金属，镁，铵和胺有机碱的当量，A和A'是易裂解酯基的剩余部分 或CO 2 A是CO 2 - 而波浪线表示CH 2 R 1在E或Z位置a 它们具有抗菌活性的无毒的，药学上可接受的酸加成盐。