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25 条记录 (耗时 0.034 秒)

    Cephalosporins
    4.
    发明授权
    Cephalosporins 失效
    头孢菌素

    公开(公告)号：US06313305B1

    公开(公告)日：2001-11-06

    申请号：US08900366

    申请日：1997-07-21

    申请人： Jozsef Aszodi ,  Jean-Francois Chantot ,  Patrick Fauveau ,  Solange Gouin d'Ambrieres ,  Daniel Humbert ,  Christophe Dini

    发明人： Jozsef Aszodi ,  Jean-Francois Chantot ,  Patrick Fauveau ,  Solange Gouin d'Ambrieres ,  Daniel Humbert ,  Christophe Dini

    IPC分类号： C07D28508

    CPC分类号： C07D501/00 ,  C07C45/63 ,  C07C45/673 ,  C07C45/71 ,  C07C47/565 ,  C07C47/575 ,  C07C59/64 ,  C07C69/734 ,  C07C205/44 ,  C07C239/20 ,  C07C255/56 ,  C07C255/57 ,  Y02P20/55

    摘要： A compound having the formula selected from the group consisting of wherein either R3p and R4p are identical and selected from the group consisting of —OH, protected —OH and acyloxy of 1 to 8 carbon atoms, R2p is selected from the group consisting of —CN, —F, Br and I and R1p and R5p are hydrogen or R5p is —F and R1p and R2p are hydrogen or R1p and R2p are F and R5p is hydrogen, or R4p and R5p are identical and selected from the group consisting of —OH, protected —OH and acyloxy of 1 to 8 carbon atoms, R3p is selected from the group consisting of F and —CN and R1p and R2p are hydrogen, R8 is hydrogen or an amine protective group and R10 is the remainder in which the hydroxy or amino are protected wherein R′1 is selected from the group consisting of alkyl of 1 to 4 carbon atoms, —CN, carboxy and alkoxy carbonyl of 1 to 4 carbon atoms.

    摘要翻译： 具有选自R3p和R4p中的式的化合物是相同的，并且选自-OH，被保护的-OH和1至8个碳原子的酰氧基，R2p选自-CN， -F，Br和I，R1p和R5p是氢或R5p是-F，R1p和R2p是氢或R1p，R2p是F，R5p是氢，或R4p和R5p是相同的，选自-OH， 保护的-OH和1至8个碳原子的酰氧基，R3p选自F和-CN，R1p和R2p是氢，R8是氢或胺保护基，R10是其中羟基或氨基 被保护，其中R'1选自1至4个碳原子的烷基，-CN，羧基和1至4个碳原子的烷氧基羰基。

    1,3-Benzodioxin derivatives
    10.
    发明授权
    1,3-Benzodioxin derivatives 失效
    1,3-苯并二恶英衍生物

    公开(公告)号：US4294845A

    公开(公告)日：1981-10-13

    申请号：US34431

    申请日：1979-04-30

    申请人： Daniel Humbert ,  Francois Clemence ,  Michele Dagnaux

    发明人： Daniel Humbert ,  Francois Clemence ,  Michele Dagnaux

    IPC分类号： A61K31/335 ,  A61K31/357 ,  A61P3/04 ,  A61P9/00 ,  C07C39/367 ,  C07D319/08

    CPC分类号： C07D319/08 ,  C07C39/367

    摘要： Novel racemic mixtures or optically active isomers of 1,3-benzodioxins of the formula ##STR1## wherein R.sub.1 ' is selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, --NH.sub.4, aluminum, non-toxic, pharmaceutically acceptable amines, alkyl of 1 to 5 carbon atoms, 2,3-dihydroxypropanyl, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl and dialkylaminoalkyl with alkyls of 1 to 4 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and phenyl and R.sub.4 and R.sub.5 are individually selected from the group consisting of hydrogen and halogen, and the non-toxic, pharmaceutically acceptable acid addition salts where R.sub.1 ' is dialkylaminoalkyl, with the proviso that R.sub.2 and R.sub.3 are not hydrogen simultaneously having hypolipemic activity and their preparation.

    摘要翻译： 下式的1,3-苯并二恶英的新型外消旋混合物或光学活性异构体其中R1'选自氢，碱金属，碱土金属，-NH4，铝，无毒，药学上可接受的 胺，1至5个碳原子的烷基，2,3-二羟基丙酰基，（2,2-二甲基-1,3-二氧戊环-4-基）甲基和具有1至4个碳原子的烷基的二烷基氨基烷基，R2选自 由氢和1至5个碳原子的烷基组成的组，R3选自氢，1至5个碳原子的烷基和苯基，R4和R5分别选自氢和卤素，和 无毒，药学上可接受的酸加成盐，其中R1'是二烷基氨基烷基，条件是R2和R3不同时具有降血脂活性及其制备。