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公开(公告)号：US07247728B2
公开(公告)日：2007-07-24
申请号：US10497511
申请日：2002-12-06
申请人： Joachim Luithle , Frank-Gerhard Böss , Christina Erb , Timo Flessner , Martin Hendrix , Marja van Kampen , Christoph Methfessel
发明人： Joachim Luithle , Frank-Gerhard Böss , Christina Erb , Timo Flessner , Martin Hendrix , Marja van Kampen , Christoph Methfessel
IPC分类号： C07D453/02 , A61K31/44
CPC分类号： A61K31/435 , C07D453/02
摘要： This application relates to bicyclic N-aryl amides of the formula R1 is a 1-aza-bicyclo[3.2.1]octyl group, a 1-aza-bicyclo[2.2.2]oct-3-yl; R2 is an optionally sustituted 8- to 10- membered heteroaryl, naphthyl, or azulenyl group; and R3 is H or (C1C6)alkyl; or a salt, solvate, or solvate of a salt of these compounds. A process for preparing these compounds, medicaments containing them, and methods for using them in treatment are also disclosed and claimed.
摘要翻译： 本申请涉及式R 1的双环N-芳基酰胺是1-叠氮 - 双环[3.2.1]辛基，1-叠氮双环[2.2.2]辛-3 - 基; R 2是任选取代的8至10元杂芳基，萘基或薁基; 和R 3是H或（C 1 -C 6）烷基; 或这些化合物的盐的盐，溶剂化物或溶剂化物。 还公开并要求保护制备这些化合物的方法，含有这些化合物的药物及其在治疗中的使用方法。
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公开(公告)号：US20120202842A1
公开(公告)日：2012-08-09
申请号：US13289346
申请日：2011-11-04
申请人： Martin Hendrix , Frank-Gerhard Böß , Christina Erb , Timo Fleßner , Marja van Kampen , Joachim Luithle , Christoph Methfessel , Welf-Burkhard Wiese
发明人： Martin Hendrix , Frank-Gerhard Böß , Christina Erb , Timo Fleßner , Marja van Kampen , Joachim Luithle , Christoph Methfessel , Welf-Burkhard Wiese
IPC分类号： A61K31/4365 , A61P25/00 , C07D495/04 , C07D453/02 , A61K31/439
CPC分类号： C07D453/02
摘要： The invention relates to novel 2-heteroarylcarboxamides, processes for their preparation, and their use for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的2-杂芳基羧酰胺，其制备方法及其用于制备用于治疗和/或预防疾病和改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US08884017B2
公开(公告)日：2014-11-11
申请号：US13289346
申请日：2011-11-04
申请人： Martin Hendrix , Frank-Gerhard Böβ , Christina Erb , Timo Fleβner , Marja van Kampen , Joachim Luithle , Christoph Methfessel , Welf-Burkhard Wiese
发明人： Martin Hendrix , Frank-Gerhard Böβ , Christina Erb , Timo Fleβner , Marja van Kampen , Joachim Luithle , Christoph Methfessel , Welf-Burkhard Wiese
IPC分类号： C07D453/02
CPC分类号： C07D453/02
摘要： The invention relates to novel 2-heteroarylcarboxamides, processes for their preparation, and their use for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的2-杂芳基羧酰胺，其制备方法及其用于制备用于治疗和/或预防疾病和改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US20100222378A1
公开(公告)日：2010-09-02
申请号：US12777764
申请日：2010-05-11
申请人： Martin Hendrix , Frank-Gerhard Böß , Christina Erb , Timo Fleßner , Marja Van Kampen , Joachim Luithle , Christoph Methfessel , Welf-Burkhard Wiese
发明人： Martin Hendrix , Frank-Gerhard Böß , Christina Erb , Timo Fleßner , Marja Van Kampen , Joachim Luithle , Christoph Methfessel , Welf-Burkhard Wiese
IPC分类号： A61K31/4365 , C07D453/02 , A61K31/439 , C07D495/04 , A61P25/00 , A61P25/28
CPC分类号： C07D453/02
摘要： The invention relates to novel 2-heteroarylcarboxamides, processes for their preparation, and their use for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的2-杂芳基羧酰胺，其制备方法及其用于制备用于治疗和/或预防疾病以及改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US08076355B2
公开(公告)日：2011-12-13
申请号：US12777764
申请日：2010-05-11
申请人： Martin Hendrix , Frank-Gerhard Böβ , Christina Erb , Timo Fleβner , Marja Van Kampen , Joachim Luithle , Christoph Methfessel , Welf-Burkhard Wiese
发明人： Martin Hendrix , Frank-Gerhard Böβ , Christina Erb , Timo Fleβner , Marja Van Kampen , Joachim Luithle , Christoph Methfessel , Welf-Burkhard Wiese
IPC分类号： A61K31/4365 , A61K31/439 , A61P25/28
CPC分类号： C07D453/02
摘要： The invention relates to novel 2-heteroarylcarboxamides, processes for their preparation, and their use for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的2-杂芳基羧酰胺，其制备方法及其用于制备用于治疗和/或预防疾病以及改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US07732477B2
公开(公告)日：2010-06-08
申请号：US10500096
申请日：2002-12-16
申请人： Martin Hendrix , Frank-Gerhard Böβ , Christina Erb , Timo Fleβner , Marja van Kampen , Joachim Luithle , Christoph Methfessel , Welf-Burkhard Wiese
发明人： Martin Hendrix , Frank-Gerhard Böβ , Christina Erb , Timo Fleβner , Marja van Kampen , Joachim Luithle , Christoph Methfessel , Welf-Burkhard Wiese
IPC分类号： A61K31/403 , C07D487/02
CPC分类号： C07D453/02
摘要： The invention relates to novel 2-heteroarylcarboxamides, processes for their preparation, and their use for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的2-杂芳基羧酰胺，其制备方法及其用于制备用于治疗和/或预防疾病和改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US07256288B2
公开(公告)日：2007-08-14
申请号：US10496404
申请日：2002-11-06
申请人： Martin Hendrix , Frank-Gerhard Böss , Christina Erb , Joachim Krüger , Joachim Luithle , Christoph Methfessel , Rudy Schreiber , Welf-Burkhard Wiese
发明人： Martin Hendrix , Frank-Gerhard Böss , Christina Erb , Joachim Krüger , Joachim Luithle , Christoph Methfessel , Rudy Schreiber , Welf-Burkhard Wiese
IPC分类号： C07D239/02 , C07D453/02
CPC分类号： C07D453/02
摘要： The invention relates to novel heteroaryl carboxamides, a process for their preparation, and pharmaceutical compositions containing them. These materials are useful for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新颖的杂芳基羧酰胺，其制备方法和含有它们的药物组合物。 这些材料可用于治疗和/或预防疾病和改善感知，集中，学习和/或记忆。
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公开(公告)号：US20050107460A1
公开(公告)日：2005-05-19
申请号：US10497511
申请日：2002-12-06
申请人： Joachim Luithle , Frank-Gerhard Boss , Christina Erb , Timo Flessner , Martin Hendrix , Marja Kampen , Christoph Methfessel
发明人： Joachim Luithle , Frank-Gerhard Boss , Christina Erb , Timo Flessner , Martin Hendrix , Marja Kampen , Christoph Methfessel
IPC分类号： A61K31/435 , A61K31/439 , A61K31/4709 , A61K31/498 , A61P25/28 , A61P43/00 , C07D453/02 , A61K31/33 , A61K31/407 , C07D471/02
CPC分类号： A61K31/435 , C07D453/02
摘要： The invention relates to novel bicylic N-arylamides, to a method for the production thereof, and to the use of the same for producing pharmaceuticals for the treatment and/or prophylaxis of diseases and for improving perception, power of concentration, learnig capacity and/or memory retention.
摘要翻译： 本发明涉及新型的二元N-芳基酰胺，其制备方法及其用途，用于制备药物用于治疗和/或预防疾病，以及改善感知，集中力，学习能力和/ 或记忆保留。
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公开(公告)号：US20050119325A1
公开(公告)日：2005-06-02
申请号：US10500096
申请日：2002-12-16
申请人： Martin Hendrix , Frank-Gerhard Boss , Christina Erb , Timo Flessner , Marja Kampen , Joachim Luithle , Christoph Methfessel , Welf-Burkhard Wiese
发明人： Martin Hendrix , Frank-Gerhard Boss , Christina Erb , Timo Flessner , Marja Kampen , Joachim Luithle , Christoph Methfessel , Welf-Burkhard Wiese
IPC分类号： C07D453/02 , C07D519/00 , A61K31/403 , C07D487/02
CPC分类号： C07D453/02
摘要： The invention relates to novel 2-heteroarylcarboxamides, processes for their preparation, and their use for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的2-杂芳基羧酰胺，其制备方法及其用于制备用于治疗和/或预防疾病和改善感知，浓度，学习和/或记忆的药物的用途。
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10.发明授权Selective phosphodiesterase 9A inhibitors as medicaments for improving cognitive processes 有权选择性磷酸二酯酶9A抑制剂作为改善认知过程的药物公开(公告)号：US09067945B2
公开(公告)日：2015-06-30
申请号：US13886850
申请日：2013-05-03
IPC分类号： A61K31/59 , A61K31/415 , C07D487/04 , A61K31/519 , C07D473/30
CPC分类号： C07D487/04 , A61K31/519 , C07D473/30
摘要： The invention relates to the use of selective phosphodiesterase 9A (PDE9A) inhibitors for producing medicaments for improving perception, concentration, cognitive processes, learning and/or memory.
摘要翻译： 本发明涉及选择性磷酸二酯酶9A（PDE9A）抑制剂用于制备用于改善感知，浓度，认知过程，学习和/或记忆的药物的用途。
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