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公开(公告)号：US08076355B2
公开(公告)日：2011-12-13
申请号：US12777764
申请日：2010-05-11
申请人： Martin Hendrix , Frank-Gerhard Böβ , Christina Erb , Timo Fleβner , Marja Van Kampen , Joachim Luithle , Christoph Methfessel , Welf-Burkhard Wiese
发明人： Martin Hendrix , Frank-Gerhard Böβ , Christina Erb , Timo Fleβner , Marja Van Kampen , Joachim Luithle , Christoph Methfessel , Welf-Burkhard Wiese
IPC分类号： A61K31/4365 , A61K31/439 , A61P25/28
CPC分类号： C07D453/02
摘要： The invention relates to novel 2-heteroarylcarboxamides, processes for their preparation, and their use for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的2-杂芳基羧酰胺，其制备方法及其用于制备用于治疗和/或预防疾病以及改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US20100222378A1
公开(公告)日：2010-09-02
申请号：US12777764
申请日：2010-05-11
申请人： Martin Hendrix , Frank-Gerhard Böß , Christina Erb , Timo Fleßner , Marja Van Kampen , Joachim Luithle , Christoph Methfessel , Welf-Burkhard Wiese
发明人： Martin Hendrix , Frank-Gerhard Böß , Christina Erb , Timo Fleßner , Marja Van Kampen , Joachim Luithle , Christoph Methfessel , Welf-Burkhard Wiese
IPC分类号： A61K31/4365 , C07D453/02 , A61K31/439 , C07D495/04 , A61P25/00 , A61P25/28
CPC分类号： C07D453/02
摘要： The invention relates to novel 2-heteroarylcarboxamides, processes for their preparation, and their use for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的2-杂芳基羧酰胺，其制备方法及其用于制备用于治疗和/或预防疾病以及改善感知，浓度，学习和/或记忆的药物的用途。
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3.发明授权Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists 有权氮杂双环氨基甲酸酯及其作为α-7烟碱乙酰胆碱受体激动剂的用途公开(公告)号：US08772511B2
公开(公告)日：2014-07-08
申请号：US13441407
申请日：2012-04-06
申请人： Timo Fleβner , Frank-Gerhard Böβ , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Dieter Lang , Joachim Luithle , Marja Van Kampen , Franz-Josef Van der Staay
发明人： Timo Fleβner , Frank-Gerhard Böβ , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Dieter Lang , Joachim Luithle , Marja Van Kampen , Franz-Josef Van der Staay
IPC分类号： C07D453/02 , C07D307/00
CPC分类号： C07D453/02
摘要： The invention relates to novel benzothiophene-, benzofuran-, and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning, and/or memory.
摘要翻译： 本发明涉及新的苯并噻吩 - ，苯并呋喃和吲哚脲，以及其用于制备用于治疗和/或预防疾病和改善感知，集中，学习和/或记忆的药物的用途。
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4.发明授权Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists 有权氮杂双环氨基甲酸酯及其作为α-7烟碱乙酰胆碱受体激动剂的用途公开(公告)号：US07795453B2
公开(公告)日：2010-09-14
申请号：US10522611
申请日：2003-07-14
申请人： Timo Fleβner , Frank-Gerhard Böβ , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Dieter Lang , Joachim Luithle , Marja Van Kampen , Franz-Josef Van der Staay
发明人： Timo Fleβner , Frank-Gerhard Böβ , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Dieter Lang , Joachim Luithle , Marja Van Kampen , Franz-Josef Van der Staay
IPC分类号： C07D333/00
CPC分类号： C07D453/02
摘要： The invention relates to novel benzothiophene-, benzofuran- and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的苯并噻吩 - ，苯并呋喃 - 和吲哚脲，以及其用于生产用于治疗和/或预防疾病和改善感知，浓度，学习和/或记忆的药物的用途。
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![Substituted pyrazolo[3,4-d]pyrimidin-4-one compounds as phosphodiesterase inhibitors](/abs-image/US/2011/10/18/US08039477B2/abs.jpg.150x150.jpg)
5.发明授权Substituted pyrazolo[3,4-d]pyrimidin-4-one compounds as phosphodiesterase inhibitors 有权取代的吡唑并[3,4-d]嘧啶-4-酮化合物作为磷酸二酯酶抑制剂公开(公告)号：US08039477B2
公开(公告)日：2011-10-18
申请号：US10524956
申请日：2003-08-13
申请人： Martin Hendrix , Frank-Gerhard Böβ , Nils Burkhardt , Christina Erb , Adrian Tersteegen , Marja Van Kampen
发明人： Martin Hendrix , Frank-Gerhard Böβ , Nils Burkhardt , Christina Erb , Adrian Tersteegen , Marja Van Kampen
IPC分类号： C07D487/04 , A61K31/519 , A61P25/28
CPC分类号： C07D487/04
摘要： The invention relates to novel alkyl-substituted pyrazolopyrimidines, process for their preparation, and the use thereof for producing medicaments for improving perception, concentration, learning and/or memory with compounds of formula (I):
摘要翻译： 本发明涉及新的烷基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善式（I）化合物的感知，浓度，学习和/或记忆的药物：
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公开(公告)号：US08741907B2
公开(公告)日：2014-06-03
申请号：US13193931
申请日：2011-07-29
申请人： Martin Hendrix , Frank-Gerhard Böβ , Nils Burkhardt , Christina Erb , Adrian Tersteegen , Marja Van Kampen
发明人： Martin Hendrix , Frank-Gerhard Böβ , Nils Burkhardt , Christina Erb , Adrian Tersteegen , Marja Van Kampen
IPC分类号： A61K31/519 , A61P25/28 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to alkyl-substituted pyrazolopyrimidines, process for their preparation, and the use thereof for producing medicaments for improving learning and/or memory. The alkyl-substituted pyrazolopyrimidines are of the formula (I): with the variables as defined in the claims.
摘要翻译： 本发明涉及烷基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善学习和/或记忆的药物的用途。 烷基取代的吡唑并嘧啶具有式（I）：具有如权利要求中所定义的变量。
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公开(公告)号：US08158633B2
公开(公告)日：2012-04-17
申请号：US10525115
申请日：2003-08-12
申请人： Martin Hendrix , Frank-Gerhard Böβ , Nils Burkhardt , Christina Erb , Adrian Tersteegen , Marja Van Kampen
发明人： Martin Hendrix , Frank-Gerhard Böβ , Nils Burkhardt , Christina Erb , Adrian Tersteegen , Marja Van Kampen
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： The invention relates to novel phenyl-substituted pyrazolopyrimidines, process for their preparation, and their use for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的苯基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US08518967B2
公开(公告)日：2013-08-27
申请号：US12494009
申请日：2009-06-29
申请人： Joachim Luithle , Frank-Gerhard Böb , Christina Erb , Katrin Schnitzler , Timo Flessner , Marja Van Kampen , Christoph Methfessel
发明人： Joachim Luithle , Frank-Gerhard Böb , Christina Erb , Katrin Schnitzler , Timo Flessner , Marja Van Kampen , Christoph Methfessel
IPC分类号： C07D453/02 , A61K31/47
CPC分类号： C07D453/02 , A61K31/439 , C07D453/04
摘要： The invention relates to novel amides of acetic and propionic acids, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory.
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公开(公告)号：US20090258898A1
公开(公告)日：2009-10-15
申请号：US12494009
申请日：2009-06-29
申请人： Joachim Luithle , Frank-Gerhard Bob , Christina Erb , Katrin Schnitzler , Timo Flessner , Marja Van Kampen , Christoph Methfessel
发明人： Joachim Luithle , Frank-Gerhard Bob , Christina Erb , Katrin Schnitzler , Timo Flessner , Marja Van Kampen , Christoph Methfessel
IPC分类号： A61K31/439 , C07D453/02 , A61P25/00
CPC分类号： C07D453/02 , A61K31/439 , C07D453/04
摘要： The invention relates to novel amides of acetic and propionic acids, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory.
摘要翻译： 本发明涉及乙酸和丙酸的新型酰胺，其生产和使用方法，用于生产用于治疗和/或预防疾病以及改善感知，浓度，学习能力和记忆力的药物。
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公开(公告)号：US20120258964A1
公开(公告)日：2012-10-11
申请号：US13412946
申请日：2012-03-06
申请人： Joachim Luithle , Frank-Gerhard Böss , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Timo Flessner , Marja Van Kampen , Franz-Josef Van Der Staay
发明人： Joachim Luithle , Frank-Gerhard Böss , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Timo Flessner , Marja Van Kampen , Franz-Josef Van Der Staay
IPC分类号： C07D453/02 , A61K31/5377 , A61P25/28 , A61K31/506 , A61P25/00 , A61K31/439 , A61K31/496
CPC分类号： C07D453/02
摘要： The invention relates to novel 2-heteroaryl carboxamides and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的2-杂芳基羧酰胺及其用于制备用于治疗和/或预防疾病和改善感知，浓度，学习和/或记忆的药物的用途。
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