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1.发明申请Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1 失效使用反义寡核苷酸或siRNA抑制eIF-5A1的表达公开(公告)号：US20060178330A1
公开(公告)日：2006-08-10
申请号：US11287460
申请日：2005-11-28
申请人： John Thompson , Bruce Galton , Catherine Taylor , Adrienne Boone , Elizabeth Helkkila , Dominic Cliche , Shelley Culp-Stewart , John Flanagan , Michelle Senchyna
发明人： John Thompson , Bruce Galton , Catherine Taylor , Adrienne Boone , Elizabeth Helkkila , Dominic Cliche , Shelley Culp-Stewart , John Flanagan , Michelle Senchyna
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡因子5A1或简单因子5A1，凋亡因子5A1核酸和多肽，以及使用反义核苷酸或siRNA至少抑制或抑制细胞凋亡的方法 抑制因子5A1的表达。 本发明还涉及通过抑制凋亡因子5A的表达抑制或抑制促炎细胞因子的表达。
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2.发明申请Use of Antisense Oligonucleotides or siRNA to Suppress Expression of eIF-5A1 审中-公开使用反义寡核苷酸或siRNA抑制eIF-5A1的表达公开(公告)号：US20130066058A1
公开(公告)日：2013-03-14
申请号：US13572123
申请日：2012-08-10
申请人： John E. Thompson , Bruce C. Galton , Catherine Taylor , Adrienne Boone , Elizabeth Margaret Heikkila , Dominic Cliche , Shelley Culp-Stewart , John Gerard Flannagan , Michelle Senchyna
发明人： John E. Thompson , Bruce C. Galton , Catherine Taylor , Adrienne Boone , Elizabeth Margaret Heikkila , Dominic Cliche , Shelley Culp-Stewart , John Gerard Flannagan , Michelle Senchyna
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡因子5A1或简单因子5A1，凋亡因子5A1核酸和多肽，以及使用反义核苷酸或siRNA至少抑制或抑制细胞凋亡的方法 抑制因子5A1的表达。 本发明还涉及通过抑制凋亡因子5A的表达抑制或抑制促炎细胞因子的表达。
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公开(公告)号：US08242256B2
公开(公告)日：2012-08-14
申请号：US12640148
申请日：2009-12-17
申请人： John E. Thompson , Bruce C. Galton , Catherine Taylor , Adrienne Boone , Elizabeth Heikkila , Dominic Cliche , Shelley Culp-Stewart , John Gerard Flanagan , Michelle Senchyna
发明人： John E. Thompson , Bruce C. Galton , Catherine Taylor , Adrienne Boone , Elizabeth Heikkila , Dominic Cliche , Shelley Culp-Stewart , John Gerard Flanagan , Michelle Senchyna
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡因子5A1或简单因子5A1，凋亡因子5A1核酸和多肽，以及使用反义核苷酸或siRNA至少抑制或抑制细胞凋亡的方法 抑制因子5A1的表达。 本发明还涉及通过抑制凋亡因子5A的表达抑制或抑制促炎细胞因子的表达。
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公开(公告)号：US20110098460A1
公开(公告)日：2011-04-28
申请号：US12640148
申请日：2009-12-17
申请人： John E. Thompson , Bruce C. Galton , Catherine Taylor , Adrienne Boone , Elizabeth Heikkila , Dominic Cliche , Shelley Culp-Stewart , John Gerard Flanagan , Michelle Senchyna
发明人： John E. Thompson , Bruce C. Galton , Catherine Taylor , Adrienne Boone , Elizabeth Heikkila , Dominic Cliche , Shelley Culp-Stewart , John Gerard Flanagan , Michelle Senchyna
IPC分类号： C07H21/02
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡因子5A1或简单因子5A1，凋亡因子5A1核酸和多肽，以及使用反义核苷酸或siRNA至少抑制或抑制细胞凋亡的方法 抑制因子5A1的表达。 本发明还涉及通过抑制凋亡因子5A的表达抑制或抑制促炎细胞因子的表达。
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5.发明授权Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1 失效使用反义寡核苷酸或siRNA抑制eIF-5A1的表达公开(公告)号：US07662796B2
公开(公告)日：2010-02-16
申请号：US11287460
申请日：2005-11-28
申请人： John E. Thompson , Bruce C. Galton , Catherine Taylor , Adrienne Boone , Elizabeth Heikkila , Dominic Cliche , Shelley Culp-Stewart , John Gerard Flanagan , Michelle Senchyna
发明人： John E. Thompson , Bruce C. Galton , Catherine Taylor , Adrienne Boone , Elizabeth Heikkila , Dominic Cliche , Shelley Culp-Stewart , John Gerard Flanagan , Michelle Senchyna
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡因子5A1或简单因子5A1，凋亡因子5A1核酸和多肽，以及使用反义核苷酸或siRNA至少抑制或抑制细胞凋亡的方法 抑制因子5A1的表达。 本发明还涉及通过抑制凋亡因子5A的表达抑制或抑制促炎细胞因子的表达。
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6.发明申请Inhibition of apoptosis-specific eIF-5A ("eIF-5A1") with antisense oligonucleotides and siRNA as anti-inflammatory therapeutics 审中-公开用反义寡核苷酸和siRNA作为抗炎治疗剂抑制凋亡特异性eIF-5A（“eIF-5A1”）公开(公告)号：US20100168047A9
公开(公告)日：2010-07-01
申请号：US11134445
申请日：2005-05-23
申请人： John Thompson , Bruce Galton , Catherine Taylor , Charles Dinarello , Leonid Reznikov , Adrienne Boone , Marianne Hopkins
发明人： John Thompson , Bruce Galton , Catherine Taylor , Charles Dinarello , Leonid Reznikov , Adrienne Boone , Marianne Hopkins
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5A1, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFKB by inhibiting expression of apoptosis-specific eIF-5A.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡特异性eIF-5A或eIF5A1，核酸和多肽，以及使用反义核苷酸或siRNA抑制或抑制细胞凋亡以抑制表达的方法 的凋亡特异性eIF-5A。 本发明还涉及通过抑制凋亡特异性eIF-5A的表达来抑制或抑制促炎细胞因子的表达或抑制NFκB的活化。
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7.发明申请Inhibition of apoptosis-specific eIF-5A ("eIF-5A1") with antisense oligonucleotides and siRNA as anti-inflammatory therapeutics 审中-公开用反义寡核苷酸和siRNA作为抗炎治疗剂抑制凋亡特异性eIF-5A（“eIF-5A1”）公开(公告)号：US20060094677A1
公开(公告)日：2006-05-04
申请号：US11134445
申请日：2005-05-23
申请人： John Thompson , Bruce Galton , Catherine Taylor , Charles Dinarello , Leonid Reznikov , Adrienne Boone , Marianne Hopkins
发明人： John Thompson , Bruce Galton , Catherine Taylor , Charles Dinarello , Leonid Reznikov , Adrienne Boone , Marianne Hopkins
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5A1, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFKB by inhibiting expression of apoptosis-specific eIF-5A.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡特异性eIF-5A或eIF5A1，核酸和多肽，以及使用反义核苷酸或siRNA抑制或抑制细胞凋亡以抑制表达的方法 的凋亡特异性eIF-5A。 本发明还涉及通过抑制凋亡特异性eIF-5A的表达来抑制或抑制促炎细胞因子的表达或抑制NFκB的活化。
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公开(公告)号：US20060287265A1
公开(公告)日：2006-12-21
申请号：US11293391
申请日：2005-12-05
申请人： John Thompson , Bruce Galton , Catherine Taylor , Charles Dinarello , Leonid Reznikov , Adrienne Boone , Marianne Hopkins
发明人： John Thompson , Bruce Galton , Catherine Taylor , Charles Dinarello , Leonid Reznikov , Adrienne Boone , Marianne Hopkins
CPC分类号： C07K14/4747 , A61K48/00
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5-A1, nucleic acids and polypeptides and methods for increasing or decreasing expression of apoptosis-specific eIF-5A. The invention also relates to methods of increasing or decreasing apoptosis.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡特异性eIF-5A或eIF5-A1核酸和多肽，以及用于增加或减少凋亡特异性eIF-5A表达的方法。 本发明还涉及增加或减少凋亡的方法。
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9.发明申请Use of apoptosis-specific eIF-5A siRNAs and antisense polynucleotides to inhibit/suppress an inflammatory response 审中-公开使用凋亡特异性eIF-5A siRNA和反义多核苷酸抑制/抑制炎性反应公开(公告)号：US20060154887A1
公开(公告)日：2006-07-13
申请号：US11184982
申请日：2005-07-20
申请人： John Thompson , Bruce Galton , Catherine Taylor , Charles Dinarello , Leonid Reznikov , Adrienne Boone , Marianne Hopkins
发明人： John Thompson , Bruce Galton , Catherine Taylor , Charles Dinarello , Leonid Reznikov , Adrienne Boone , Marianne Hopkins
CPC分类号： C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5-A1, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFkB by inhibiting expression of apoptosis-specific eIF-5A.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），被称为凋亡特异性eIF-5A或eIF5-A1核酸和多肽，以及使用反义核苷酸或siRNA对细胞凋亡抑制或抑制凋亡的方法 抑制凋亡特异性eIF-5A的表达。 本发明还涉及通过抑制细胞凋亡特异性eIF-5A的表达来抑制或抑制促炎细胞因子的表达或抑制NFkB的活化。
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10.发明授权Inhibition of apoptosis-specific eIF-5A(eIF-5A1″) with antisense oligonucleotides and siRNA as anti-inflammatory therapeutics 失效用反义寡核苷酸和siRNA作为抗炎治疗剂抑制凋亡特异性eIF-5A（“eIF-5A1”）公开(公告)号：US08754057B2
公开(公告)日：2014-06-17
申请号：US13099171
申请日：2011-05-02
申请人： John E. Thompson , Bruce C. Galton , Catherine Taylor , Charles Dinarello , Leonid Reznikov , Adrienne Boone , Marianne Hopkins
发明人： John E. Thompson , Bruce C. Galton , Catherine Taylor , Charles Dinarello , Leonid Reznikov , Adrienne Boone , Marianne Hopkins
IPC分类号： C12N15/11 , C12N15/113
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5A1, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFkB by inhibiting expression of apoptosis-specific eIF-5A.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡特异性eIF-5A或eIF5A1，核酸和多肽，以及使用反义核苷酸或siRNA抑制或抑制细胞凋亡以抑制表达的方法 的凋亡特异性eIF-5A。 本发明还涉及通过抑制细胞凋亡特异性eIF-5A的表达来抑制或抑制促炎细胞因子的表达或抑制NFkB的活化。
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