公开(公告)号：US20100226933A1

公开(公告)日：2010-09-09

申请号：US12526267

申请日：2008-02-13

申请人： Josef Thalhamer ,  Arnulf Hartl ,  Manfred Sippl ,  Peter Lackner ,  Fatima Ferreira-Briza ,  Theresa Thalhamer ,  Hanno Stutz

发明人： Josef Thalhamer ,  Arnulf Hartl ,  Manfred Sippl ,  Peter Lackner ,  Fatima Ferreira-Briza ,  Theresa Thalhamer ,  Hanno Stutz

IPC分类号： A61K39/00 ,  G01N33/53 ,  G01N33/00 ,  C07K14/00 ,  A61P37/08 ,  G06F19/00

CPC分类号： G01N33/6893 ,  G01N2800/24

摘要： The present invention relates to a method for identifying a hypoallergenic derivative of a wild-type allergen comprising: determining the three-dimensional structure of a wild-type allergen; introducing at least one point mutation into said wild-type allergen, thereby obtaining a mutated allergen; identifying a hypoallergenic derivative of said wild-type allergen by detecting a destabilisation or change of the three-dimensional structure of the mutated allergen compared to the wild-type allergen by determining energy differences between the wild-type allergen and the mutant allergen expressed as a Z-score.

摘要翻译： 本发明涉及用于鉴定野生型变应原的低变应原性衍生物的方法，其包括：确定野生型变应原的三维结构; 将至少一个点突变引入所述野生型变应原，从而获得突变的变应原; 通过检测野生型变应原与突变型变应原之间的能量差异，与野生型变应原相比，通过检测突变变应原的三维结构的不稳定或变化来鉴定所述野生型变应原的低变应原性衍生物 Z得分。