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公开(公告)号:US20110217334A1
公开(公告)日:2011-09-08
申请号:US12674195
申请日:2008-06-30
申请人: Michael Wallner , Barbara Bohle , Martin Himly , Nicole Wopfner , Gabriele Gadermaier , Matthias Egger , Peter Lackner , Fatima Ferreira , Michael Hauser
发明人: Michael Wallner , Barbara Bohle , Martin Himly , Nicole Wopfner , Gabriele Gadermaier , Matthias Egger , Peter Lackner , Fatima Ferreira , Michael Hauser
IPC分类号: A61K39/35 , C07K14/415 , C12N15/63 , C07H21/00 , A61P37/08
CPC分类号: C07K14/415
摘要: The present invention relates to a hypoallergenic molecule consisting of Bet v Ia or an allergen having at least 40% identity to Bet v Ia comprising mutations of at least four amino acid residues in the region of amino acids 100 to 125 of Bet v Ia or its corresponding region of the allergen having at least 40% identity to Bet v Ia.
摘要翻译: 本发明涉及由Bet v 1a或与Bet v Ia具有至少40%同一性的变应原组成的低变应原性分子,其包含Bet v Ia的氨基酸100至125的区域中至少四个氨基酸残基的突变或其 与Bet v Ia具有至少40%同一性的变应原的相应区域。
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公开(公告)号:US4220970A
公开(公告)日:1980-09-02
申请号:US856975
申请日:1977-12-02
申请人: Ibolya Haraszti , Peter Lackner , Willy Minner
发明人: Ibolya Haraszti , Peter Lackner , Willy Minner
摘要: The circuitry is used, for identifying television transmitters, in a television set receiving synchronizing signals and line flyback pulses characteristic of television transmitters, particularly for television receivers including a station finder circuit. The circuitry, during the time period of the line flyback pulses, derives samples of those signals appearing above the black level of the video signal, from the demodulated input signal. The number of amplitude jumps determined during the time period of the line flyback pulses is utilized as the criterion for identification of a television transmitter. The signals appearing above the black level of the video signal are inverted and then combined, in an AND circuit, with the line flyback pulses, and the output of the AND circuit is connected to a digital counter circuit to supply the output pulses thereto as counting pulses, with the flyback pulses being supplied to the digital counter circuit as gate pulses. An inverter is connected to the output of the counter circuit and a logic "1" potential appears at the output of the inverter only in the case where a single pulse has been delivered to the counter circuit during the gate time, with a logic "0" potential appearing at the output of the inverter in all other cases. The output of the inverter is connected, through an integrating circuit, to a threshold circuit providing an output signal which indicates whether a television transmitter has been identified.
摘要翻译: 该电路用于识别电视机中的电视机,该电视机接收电视发射机特性的同步信号和线路反激脉冲,特别是用于包括测站仪电路的电视接收机。 在线路反激脉冲的时间段期间,电路从解调的输入信号中导出出现在视频信号的黑电平之上的那些信号的采样。 在线路反激脉冲的时间段期间确定的振幅跳数被用作电视发射机的识别标准。 出现在视频信号的黑电平上方的信号被反相,然后在AND电路中与线回扫脉冲相结合,AND电路的输出连接到数字计数器电路,以将输出脉冲提供给计数 脉冲,其中回扫脉冲作为门脉冲被提供给数字计数器电路。 反相器连接到计数器电路的输出端,只有在栅极时间内单个脉冲输送到计数器电路的情况下,逻辑“1”电位出现在反相器的输出端,逻辑“0” “在所有其他情况下,逆变器的输出出现电位。 逆变器的输出通过积分电路连接到提供指示电视发射机是否被识别的输出信号的阈值电路。
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公开(公告)号:US09040054B2
公开(公告)日:2015-05-26
申请号:US12674195
申请日:2008-06-30
申请人: Michael Wallner , Barbara Bohle , Martin Himly , Nicole Wopfner , Gabriele Gadermaier , Matthias Egger , Peter Lackner , Fatima Ferreira , Michael Hauser
发明人: Michael Wallner , Barbara Bohle , Martin Himly , Nicole Wopfner , Gabriele Gadermaier , Matthias Egger , Peter Lackner , Fatima Ferreira , Michael Hauser
IPC分类号: A61K36/00 , A61K39/00 , A61K39/35 , A61K39/36 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07K14/415
CPC分类号: C07K14/415
摘要: The present invention relates to a hypoallergenic molecule consisting of Bet v Ia or an allergen having at least 40% identity to Bet v Ia comprising mutations of at least four amino acid residues in the region of amino acids 100 to 125 of Bet v Ia or its corresponding region of the allergen having at least 40% identity to Bet v 1a.
摘要翻译: 本发明涉及由Bet v 1a或与Bet v Ia具有至少40%同一性的变应原组成的低变应原性分子,其包含Bet v Ia的氨基酸100至125的区域中至少四个氨基酸残基的突变或其 与Bet v 1a具有至少40%同一性的变应原的相应区域。
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公开(公告)号:US20100226933A1
公开(公告)日:2010-09-09
申请号:US12526267
申请日:2008-02-13
申请人: Josef Thalhamer , Arnulf Hartl , Manfred Sippl , Peter Lackner , Fatima Ferreira-Briza , Theresa Thalhamer , Hanno Stutz
发明人: Josef Thalhamer , Arnulf Hartl , Manfred Sippl , Peter Lackner , Fatima Ferreira-Briza , Theresa Thalhamer , Hanno Stutz
CPC分类号: G01N33/6893 , G01N2800/24
摘要: The present invention relates to a method for identifying a hypoallergenic derivative of a wild-type allergen comprising: determining the three-dimensional structure of a wild-type allergen; introducing at least one point mutation into said wild-type allergen, thereby obtaining a mutated allergen; identifying a hypoallergenic derivative of said wild-type allergen by detecting a destabilisation or change of the three-dimensional structure of the mutated allergen compared to the wild-type allergen by determining energy differences between the wild-type allergen and the mutant allergen expressed as a Z-score.
摘要翻译: 本发明涉及用于鉴定野生型变应原的低变应原性衍生物的方法,其包括:确定野生型变应原的三维结构; 将至少一个点突变引入所述野生型变应原,从而获得突变的变应原; 通过检测野生型变应原与突变型变应原之间的能量差异,与野生型变应原相比,通过检测突变变应原的三维结构的不稳定或变化来鉴定所述野生型变应原的低变应原性衍生物 Z得分。
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