公开(公告)号：US20080119747A1

公开(公告)日：2008-05-22

申请号：US12018768

申请日：2008-01-23

申请人： Joseph MIETUS ,  Chung-Kang Peng ,  Robert Thomas ,  Ary Goldberger

发明人： Joseph MIETUS ,  Chung-Kang Peng ,  Robert Thomas ,  Ary Goldberger

IPC分类号： A61B5/0205

CPC分类号： A61B5/0456 ,  A61B5/0205 ,  A61B5/0476 ,  A61B5/0496 ,  A61B5/0816 ,  A61B5/4815 ,  A61B5/4818 ,  A61B5/7257 ,  A61B5/7278

摘要： An assessment of sleep quality and sleep disordered breathing is determined from the cardiopulmonary coupling between two physiological data series. In an embodiment, an R-R interval series is derived from an electrocardiogram (ECG) signal. The normal beats from the R-R interval series are extracted to produce a normal-to-normal (NN) interval series. The amplitude variations in the QRS complex are used to extract to a surrogate respiration signal (i.e., ECG-derived respiration (EDR)) that is associated with the NN interval series. The two series are corrected to remove outliers, and resampled. The cross-spectral power and coherence of the two resampled signals are calculated over a plurality of coherence windows. For each coherence window, the product of the coherence and cross-spectral power is used to calculate coherent cross power. Using the appropriate thresholds for the coherent cross power, the proportion of sleep spent in CAP, non-CAP, and wake and/or REM are determined.

摘要翻译： 睡眠质量和睡眠呼吸紊乱的评估是从两个生理数据序列之间的心肺耦合确定的。 在一个实施例中，从心电图（ECG）信号导出R-R间期序列。 提取R-R间隔序列中的正常搏动以产生正常到正常（NN）间隔序列。 QRS复合物中的幅度变化用于提取与NN间期序列相关联的替代呼吸信号（即，ECG导出的呼吸（EDR））。 纠正这两个系列以消除异常值，并重新采样。 在多个相干窗口上计算两个重采样信号的交叉光谱功率和相干性。 对于每个相干窗口，使用相干和交叉光谱功率的乘积来计算相干交叉功率。 使用相关交叉功率的适当阈值，确定在CAP，非CAP和唤醒和/或REM中花费的睡眠比例。