公开(公告)号：US20060205024A1

公开(公告)日：2006-09-14

申请号：US11371667

申请日：2006-03-08

申请人： Joseph Rogers ,  Rena Li ,  Diego Mastroeni ,  Andrew Grover ,  Marwan Sabbagh

发明人： Joseph Rogers ,  Rena Li ,  Diego Mastroeni ,  Andrew Grover ,  Marwan Sabbagh

IPC分类号： G01N33/537 ,  G01N33/53 ,  G01N33/543 ,  G01N33/00

CPC分类号： G01N33/6896 ,  G01N2800/2821

摘要： A method or technique of detecting, diagnosing, monitoring, and evaluating a neurodegenerative disease, such as Alzheimer's disease, in a human body fluid is disclosed. The invention provides for a method of detecting amyloid peptides associated with erythrocytes and amyloid peptide complement complexes, as a diagnostic test for the detection, monitoring, evaluation or diagnosis of Alzheimer's disease and amyloid-based neurodegenerative diseases. More specifically the invention is directed to a method for detecting presence and amount of amyloid peptides such as amyloid beta (“Aβ”) and Aβ complement complexes, and related complement complexes and compounds with a role in neurodegenerative diseases, in an erythrocyte fraction of a human bodily fluid.

摘要翻译： 公开了一种在人体液中检测，诊断，监测和评价神经变性疾病如阿尔茨海默氏病的方法或技术。 本发明提供了检测与红细胞和淀粉样蛋白肽补体复合物相关的淀粉样肽的方法，作为阿尔茨海默氏病和淀粉样蛋白基神经变性疾病的检测，监测，评价或诊断的诊断试验。 更具体地，本发明涉及一种用于检测淀粉样肽如淀粉样蛋白β（“Abeta”）和Abeta补体复合物的存在和量的方法，以及相关的补体复合物和在神经变性疾病中起作用的化合物，其在红细胞分数 人体液体