公开(公告)号：US20060205024A1

公开(公告)日：2006-09-14

申请号：US11371667

申请日：2006-03-08

申请人： Joseph Rogers ,  Rena Li ,  Diego Mastroeni ,  Andrew Grover ,  Marwan Sabbagh

发明人： Joseph Rogers ,  Rena Li ,  Diego Mastroeni ,  Andrew Grover ,  Marwan Sabbagh

IPC分类号： G01N33/537 ,  G01N33/53 ,  G01N33/543 ,  G01N33/00

CPC分类号： G01N33/6896 ,  G01N2800/2821

摘要： A method or technique of detecting, diagnosing, monitoring, and evaluating a neurodegenerative disease, such as Alzheimer's disease, in a human body fluid is disclosed. The invention provides for a method of detecting amyloid peptides associated with erythrocytes and amyloid peptide complement complexes, as a diagnostic test for the detection, monitoring, evaluation or diagnosis of Alzheimer's disease and amyloid-based neurodegenerative diseases. More specifically the invention is directed to a method for detecting presence and amount of amyloid peptides such as amyloid beta (“Aβ”) and Aβ complement complexes, and related complement complexes and compounds with a role in neurodegenerative diseases, in an erythrocyte fraction of a human bodily fluid.

摘要翻译： 公开了一种在人体液中检测，诊断，监测和评价神经变性疾病如阿尔茨海默氏病的方法或技术。 本发明提供了检测与红细胞和淀粉样蛋白肽补体复合物相关的淀粉样肽的方法，作为阿尔茨海默氏病和淀粉样蛋白基神经变性疾病的检测，监测，评价或诊断的诊断试验。 更具体地，本发明涉及一种用于检测淀粉样肽如淀粉样蛋白β（“Abeta”）和Abeta补体复合物的存在和量的方法，以及相关的补体复合物和在神经变性疾病中起作用的化合物，其在红细胞分数 人体液体

公开(公告)号：US20060068501A1

公开(公告)日：2006-03-30

申请号：US10952750

申请日：2004-09-30

申请人： Rena Li ,  LiBang Yang ,  Yong Shen

发明人： Rena Li ,  LiBang Yang ,  Yong Shen

IPC分类号： G01N33/558

CPC分类号： G01N33/558 ,  G01N33/743

摘要： An immuno-chromatographic detection device for detecting an analyte in sample, such as estrogen in a urine or saliva sample, the device comprising (a) a binding membrane having immobilized thereon (i) an test antibody against said analyte in at least one detection region, and (ii) a control antibody against a control antigen known to be present in the sample in a control region, (b) a sample membrane located at a first end of the binding membrane for receiving the sample, wherein the sample membrane is in chromatographic connection with the binding membrane, and (c) a label membrane containing (iii) a labeled antigen that is capable of binding to the test antibody and upon binding with the test antibody exhibits an observable change at the at least one detection region, and (iv) a labeled control antigen that is capable of binding to the control antibody and upon binding with the control antibody exhibits an observable change at the control region, wherein the sample membrane is separated from the label membrane by a waterproof membrane which is removable to allow the sample membrane and label membrane to be connected chromatographically. Also provided are kits comprising the device, method for detecting the analyte, and methods for manufacturing the device and kit.

摘要翻译： 一种免疫色谱检测装置，用于检测样品中的分析物，例如尿液或唾液样品中的雌激素，所述装置包括（a）在其上固定有结合膜（i）在至少一个检测区域中对所述分析物的测试抗体 ，和（ii）对照已知存在于对照区域中的样品中的对照抗原的对照抗体，（b）位于接合样品的结合膜第一端的样品膜，其中样品膜处于 与所述结合膜的色谱连接，和（c）含有（iii）能够结合所述测试抗体的标记抗原并与测试抗体结合的标记膜在所述至少一个检测区域显示出可观察到的变化，以及 （iv）能够结合对照抗体并与对照抗体结合的标记对照抗原在对照区域显示可观察到的变化，其中样品膜是分离的 通过可拆卸的防水膜从标签膜上取出，以使样品膜和标签膜进行色谱连接。 还提供了包括该装置，用于检测分析物的方法和用于制造该装置和试剂盒的方法的试剂盒。

公开(公告)号：US20050284470A1

公开(公告)日：2005-12-29

申请号：US11166736

申请日：2005-06-27

申请人： Chengping Wei ,  Linda Wei ,  Rena Li ,  Yong Shen

发明人： Chengping Wei ,  Linda Wei ,  Rena Li ,  Yong Shen

IPC分类号： A61M11/00 ,  A61M11/04 ,  A61M15/00 ,  A61M16/06 ,  A62B18/00 ,  A62B18/02

CPC分类号： A61M11/041 ,  A61M15/005 ,  A61M16/0683 ,  A61M16/107 ,  A62B18/003

摘要： A portable or wearable device and related methods of use that provide an altered microenvironment surrounding the respiratory path, specifically a person's mouth or nose, wherein the air in the microenvironment is either filtered to remove pollutants or pathogens, or wherein the air is altered by therapeutic or pharmaceutical or other agents, which disinfect the air or otherwise provide a desirable characteristic. In an alternative embodiment, a therapeutic or pharmaceutical agent is delivered to the air path to the individual wearing the device of the present invention.

摘要翻译： 便携式或可穿戴装置和相关使用方法，其提供围绕呼吸路径的改变的微环境，特别是人的嘴或鼻，其中微环境中的空气被过滤以除去污染物或病原体，或其中空气被治疗 或药物或其它试剂，其消毒空气或以其它方式提供期望的特性。 在替代实施例中，治疗剂或药剂被递送到穿过本发明的装置的个体的空气路径中。