公开(公告)号：US20240132625A1

公开(公告)日：2024-04-25

申请号：US18357665

申请日：2023-07-23

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Byung-Ha OH ,  Bo-Seong JEONG ,  Seong-Woo KIM ,  Seong-Bin IM ,  Jinyeop SONG

IPC: C07K16/46 ,  C07K14/47 ,  C07K14/52

CPC classification number: C07K16/46 ,  C07K14/47 ,  C07K14/522 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/54

Abstract: The present invention relates to a conjugate in which a polypeptide capable of forming a dimer is fused to the C-terminus of the heavy chain or light chain of an antibody or fragment thereof, a composition for increasing antigen-binding avidity of an antibody in proportion to the density of a target antigen, and a method for increasing antigen-binding avidity using the same. The present invention also relates to the treatment or diagnosis of diseases using the conjugate.

公开(公告)号：US20240228669A9

公开(公告)日：2024-07-11

申请号：US18357665

申请日：2023-07-24

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Byung-Ha OH ,  Bo-Seong JEONG ,  Seong-Woo KIM ,  Seong-Bin IM ,  Jinyeop SONG

IPC: C07K16/46 ,  C07K14/47 ,  C07K14/52

CPC classification number: C07K16/46 ,  C07K14/47 ,  C07K14/522 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/54

Abstract: The present invention relates to a conjugate in which a polypeptide capable of forming a dimer is fused to the C-terminus of the heavy chain or light chain of an antibody or fragment thereof, a composition for increasing antigen-binding avidity of an antibody in proportion to the density of a target antigen, and a method for increasing antigen-binding avidity using the same. The present invention also relates to the treatment or diagnosis of diseases using the conjugate.