公开(公告)号：US20240360186A1

公开(公告)日：2024-10-31

申请号：US18273868

申请日：2022-01-28

申请人： Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center

发明人： Jinhua Wu

IPC分类号： C07K14/47 ,  A61K38/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K2319/10 ,  C07K2319/30 ,  C07K2319/60

摘要： The present disclosure provides, in part, structurally stabilized peptidomimetic compounds that can be used in treatment of integrin-related disorders, to methods of producing structurally stabilized peptidomimetic compounds, and to methods of treating integrin-related disorders by administering structurally stabilized peptidomimetic compounds to subjects in need thereof.

公开(公告)号：US20240352085A1

公开(公告)日：2024-10-24

申请号：US18602534

申请日：2024-03-12

申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED

发明人： Qiuhong LI ,  Mohan RAIZADA

IPC分类号： C07K14/575 ,  A61K35/00 ,  A61K35/74 ,  A61K35/741 ,  A61K35/747 ,  A61K45/06 ,  A61K48/00 ,  A61P3/00 ,  A61P3/10 ,  A61P9/12 ,  A61P27/02 ,  A61P29/00 ,  C07K7/14 ,  C07K14/195 ,  C07K14/28 ,  C07K14/47 ,  C07K19/00 ,  C12N1/00 ,  C12N9/48

CPC分类号： C07K14/575 ,  A61K35/74 ,  A61K35/741 ,  A61K35/747 ,  A61K45/06 ,  A61P3/00 ,  A61P3/10 ,  A61P9/12 ,  A61P27/02 ,  A61P29/00 ,  C07K7/14 ,  C07K14/195 ,  C07K14/28 ,  C07K14/47 ,  C07K19/00 ,  C12N1/00 ,  C12N9/485 ,  A61K2035/115 ,  A61K48/00 ,  C07K2319/02 ,  C07K2319/50 ,  C07K2319/60

摘要： Provided herein are polynucleic acids and expression vectors for the expression and secretion of angiotensin peptide fragments (e.g., angiotensin-(1-7)) in probiotic bacteria. Provided herein are also probiotic compositions that enable efficient, cost-effective and patient friendly oral therapeutics for treating diverse pathological conditions that involve the renin-angiotensin system (RAS), e.g., pulmonary hypertension, diabetes, diabetic complications, cardiovascular diseases, and ocular inflammatory and neurodegenerative diseases.

公开(公告)号：US20240342310A1

公开(公告)日：2024-10-17

申请号：US18625283

申请日：2024-04-03

申请人： University of Virginia Patent Foundation ,  Sun Yat Sen Memorial Hospital, Sun Yat Sen University

发明人： Hui Li ,  Qiong Wang ,  Hai Huang

IPC分类号： A61K48/00 ,  A61K38/00 ,  A61P35/00 ,  C07K14/47

CPC分类号： A61K48/005 ,  A61P35/00 ,  C07K14/47 ,  A61K38/00 ,  C07K2319/02

摘要： Disclosed herein are peptides and peptidomimetics that inhibit the progression of prostate cancer by up-regulating FLRT3. Also disclosed are methods for treating an FLRT3-attenuated cancer in a subject that involve administering to the subject the disclosed polypeptide or peptidomimetic or a polynucleotide encoding the disclosed peptide.

公开(公告)号：US20240327527A1

公开(公告)日：2024-10-03

申请号：US18436554

申请日：2024-02-08

申请人： ALX Oncology Inc.

发明人： Marija VRLJIC ,  Jaume PONS

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C07K14/47 ,  C07K14/52 ,  C07K14/54 ,  C07K16/32

CPC分类号： C07K16/2863 ,  A61P35/00 ,  C07K14/47 ,  C07K14/52 ,  C07K14/5428 ,  C07K14/5434 ,  C07K16/2818 ,  C07K16/32 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/55 ,  C07K2317/62 ,  C07K2317/76 ,  C07K2319/01 ,  C07K2319/30 ,  C07K2319/50

摘要： The present application provides activatable antibodies comprising an antibody comprising an antigen-binding domain (ABD), wherein the ABD comprises a heavy chain variable region (VH) and a light chain variable region (VL), wherein the N-terminus of the VH is fused to a first polypeptide shield moiety (S1), and the N-terminus of the VL is fused to a second polypeptide shield moiety (S2), wherein S1 comprises a first disease-sensing releasable moiety (DS1) and/or S2 comprises a second disease-sensing releasable moiety (DS2), wherein association of S1 with S2 blocks binding of the ABD to its target, and wherein the ABD does not specifically bind to S1, S2, or association thereof. Composition, methods of treatment using the activatable antibodies, and methods of preparation thereof are further provided.

公开(公告)号：US20240327476A1

公开(公告)日：2024-10-03

申请号：US18634220

申请日：2024-04-12

申请人： ModernaTx, Inc.

发明人： Antonin DE FOUGEROLLES ,  Justin GUILD

IPC分类号： C07K14/47 ,  A61K9/00 ,  A61K9/127 ,  A61K9/14 ,  A61K9/50 ,  A61K9/51 ,  A61K31/7088 ,  A61K31/7115 ,  A61K38/00 ,  A61K38/17 ,  A61K38/18 ,  A61K38/19 ,  A61K38/21 ,  A61K38/36 ,  A61K38/44 ,  A61K38/45 ,  A61K38/48 ,  A61K39/395 ,  A61K47/10 ,  A61K47/34 ,  A61K47/54 ,  A61K48/00 ,  C07K14/005 ,  C07K14/435 ,  C07K14/475 ,  C07K14/485 ,  C07K14/505 ,  C07K14/515 ,  C07K14/525 ,  C07K14/535 ,  C07K14/56 ,  C07K14/565 ,  C07K14/62 ,  C07K14/705 ,  C07K14/745 ,  C07K14/75 ,  C07K16/00 ,  C07K16/28 ,  C07K16/32 ,  C07K19/00 ,  C12N9/00 ,  C12N9/02 ,  C12N9/10 ,  C12N9/16 ,  C12N9/24 ,  C12N9/42 ,  C12N9/64 ,  C12N9/88 ,  C12N15/11 ,  C12N15/52 ,  C12N15/67 ,  C12N15/85 ,  C12N15/87 ,  C12N15/88 ,  C12P13/04 ,  C12P21/00

CPC分类号： C07K14/47 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/1277 ,  A61K9/14 ,  A61K9/145 ,  A61K9/5031 ,  A61K9/5123 ,  A61K9/5146 ,  A61K9/5153 ,  A61K31/7088 ,  A61K31/7115 ,  A61K38/17 ,  A61K38/1767 ,  A61K38/177 ,  A61K38/1816 ,  A61K38/1866 ,  A61K38/1891 ,  A61K38/191 ,  A61K38/193 ,  A61K38/212 ,  A61K38/215 ,  A61K38/36 ,  A61K38/363 ,  A61K38/44 ,  A61K38/45 ,  A61K38/4833 ,  A61K38/4846 ,  A61K39/3955 ,  A61K47/10 ,  A61K47/34 ,  A61K47/54 ,  A61K47/542 ,  A61K47/543 ,  A61K48/0033 ,  A61K48/005 ,  A61K48/0066 ,  A61K48/0075 ,  C07K14/005 ,  C07K14/435 ,  C07K14/4705 ,  C07K14/4713 ,  C07K14/485 ,  C07K14/505 ,  C07K14/515 ,  C07K14/525 ,  C07K14/535 ,  C07K14/56 ,  C07K14/565 ,  C07K14/62 ,  C07K14/705 ,  C07K14/745 ,  C07K14/75 ,  C07K16/00 ,  C07K16/2887 ,  C07K16/32 ,  C07K19/00 ,  C12N9/0069 ,  C12N9/1051 ,  C12N9/16 ,  C12N9/2402 ,  C12N9/2445 ,  C12N9/644 ,  C12N9/6451 ,  C12N9/88 ,  C12N9/93 ,  C12N15/11 ,  C12N15/52 ,  C12N15/67 ,  C12N15/85 ,  C12N15/87 ,  C12N15/88 ,  C12P13/04 ,  C12P21/00 ,  C12P21/005 ,  C12Y113/12007 ,  C12Y304/21005 ,  C12Y603/02019 ,  A61K9/0019 ,  A61K38/00 ,  A61K48/00 ,  C07K14/475 ,  C12N2840/00 ,  C12N2840/85 ,  C12Y304/21022

摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

公开(公告)号：US20240327461A1

公开(公告)日：2024-10-03

申请号：US18497081

申请日：2024-06-11

申请人： AMGEN INC.

发明人： Jerry Ryan HOLDER ,  Gayathri SWAMINATH ,  Michael J. FROHN ,  Brian Alan LANMAN ,  Anthony B. REED ,  Leslie P. MIRANDA ,  John Gordon ALLEN ,  Alexander J. PICKRELL ,  Aaron C. SIEGMUND ,  Lewis D. PENNINGTON ,  Bryant YANG

IPC分类号： C07K7/08 ,  A61K38/00 ,  A61K38/10 ,  A61K47/54 ,  A61K47/60 ,  C07K14/47

CPC分类号： C07K7/08 ,  A61K38/10 ,  A61K47/542 ,  A61K47/60 ,  C07K14/47 ,  A61K38/00 ,  C07K2319/30

摘要： The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.

公开(公告)号：US12102691B2

公开(公告)日：2024-10-01

申请号：US17350769

申请日：2021-06-17

申请人： Massachusetts Eye and Ear Infirmary ,  President and Fellows of Harvard College

发明人： Zheng-Yi Chen ,  David R. Liu ,  Margie Li ,  David B. Thompson ,  John Zuris

IPC分类号： A61K48/00 ,  A61K9/127 ,  A61K38/00 ,  A61K38/10 ,  A61K47/64 ,  A61K47/69 ,  C07J7/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/46 ,  C07K14/47 ,  C07K19/00 ,  C12N5/0793 ,  C12N9/00 ,  C12N9/22 ,  C12N9/52 ,  C12N15/11 ,  C12N15/113 ,  C12N15/87 ,  C12N15/88 ,  C12N15/90

CPC分类号： A61K48/0008 ,  A61K9/1272 ,  A61K38/00 ,  A61K38/10 ,  A61K47/64 ,  A61K47/6911 ,  A61K48/0075 ,  A61K48/0083 ,  C07J7/009 ,  C07K7/06 ,  C07K7/08 ,  C07K14/463 ,  C07K14/47 ,  C07K19/00 ,  C12N5/062 ,  C12N9/00 ,  C12N9/22 ,  C12N9/52 ,  C12N15/11 ,  C12N15/113 ,  C12N15/87 ,  C12N15/88 ,  C12N15/907 ,  C12Y304/2207 ,  C07K2319/06 ,  C07K2319/21 ,  C07K2319/33 ,  C07K2319/60 ,  C12N2310/20 ,  C12N2310/3513 ,  C12N2510/00

摘要： Compositions are described for direct protein delivery into multiple cell types in the mammalian inner ear. The compositions are used to deliver protein(s) (such as gene editing factors) editing of genetic mutations associated with deafness or associated disorders thereof. The delivery of genome editing proteins for gene editing and correction of genetic mutations protect or restore hearing from genetic deafness. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.

公开(公告)号：US20240318199A1

公开(公告)日：2024-09-26

申请号：US18372868

申请日：2023-09-26

申请人： Beacon Therapeutics Limited

发明人： Juan Li ,  Tanaz Farivar ,  Savitri Mandapati ,  Steven Pennock ,  Mark Shearman ,  Judith Newmark ,  Adrian M. Timmers

IPC分类号： C12N15/86 ,  C07K14/47

CPC分类号： C12N15/86 ,  C07K14/47 ,  C12N2750/14141

摘要： The disclosure provides, in part, optimally-modified progranulin (PGRN) cDNA and associated genetic elements for use in recombinant adeno-associated virus (rAAV)-based gene therapy for neurodegenerative disorders characterized by cognitive disruption, behavioral impairment, and deficient lysosomal storage, including familial frontotemporal dementia (FTD), frontotemporal lobar degeneration (FTLD), neuronal ceroid lipofuscinosis (NCL), or Alzheimer's disease (AD).

公开(公告)号：US20240317842A1

公开(公告)日：2024-09-26

申请号：US18263217

申请日：2022-01-28

申请人： THE HOSPITAL FOR SICK CHILDREN

发明人： Jean-Philippe Julien ,  Edurne Rujas Diez

IPC分类号： C07K16/10 ,  A61K39/00 ,  A61P31/18 ,  C07K14/47

CPC分类号： C07K16/1063 ,  A61P31/18 ,  C07K14/47 ,  A61K2039/505 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/94 ,  C07K2319/30

摘要： In aspects, a fusion protein comprises a nanocage monomer or a subunit thereof linked to an Fc monomer, wherein a plurality of the fusion proteins are capable of self-assembling to form a nanocage comprising one or more Fc dimers. In aspects, a fusion protein comprises a nanocage monomer or a subunit thereof linked to an Fc monomer or scFc fragment at the C-terminus of the nanocage monomer or subunit thereof, wherein a plurality of the fusion proteins are capable of self-assembling to form a nanocage.

公开(公告)号：US12097249B2

公开(公告)日：2024-09-24

申请号：US17581049

申请日：2022-01-21

申请人： Immatics Biotechnologies GmbH

发明人： Andrea Mahr ,  Toni Weinschenk ,  Oliver Schoor ,  Jens Fritsche ,  Harpreet Singh ,  Phillip Mueller ,  Julia Leibold ,  Valentina Goldfinger

IPC分类号： A61K39/00 ,  C07K14/47 ,  C07K14/725 ,  C07K16/30 ,  C12N5/0783 ,  C12N15/115 ,  C12Q1/6886 ,  G01N33/574 ,  G01N33/68 ,  A61K38/00

CPC分类号： A61K39/0011 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/7051 ,  C07K16/30 ,  C12N5/0636 ,  C12N15/115 ,  C12Q1/6886 ,  G01N33/5748 ,  G01N33/6848 ,  A61K38/00 ,  A61K2039/5158 ,  A61K2039/572 ,  C07K2319/00 ,  C12N2310/16 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57407 ,  G01N2570/00 ,  G01N2800/52

摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.