公开(公告)号：US20200018759A1

公开(公告)日：2020-01-16

申请号：US15545552

申请日：2017-04-27

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Jong Shin Yoo ,  Kwang Hoe Kim ,  Jin Young Kim ,  Ju Yeon Lee

IPC: G01N33/574 ,  G01N33/68

Abstract: The present invention relates to a diagnosis method of liver cancer using mass spectrometry of α-fetoprotein derived glycopeptide. Particularly, according to the AFP glycopeptide analysis method of the invention, fucosylation rate of the glycopeptide having the sequence composed of Val-Asn-Phe-Thr-Glu-Ile-Gln-Lys is analyzed to diagnose liver cancer in the early developmental grade. In particular, fucosylation rate is higher in the liver cancer patients than in other liver disease patients, so that the comparison of the fucosylation rate can be useful to diagnose or distinguish liver cancer from other liver diseases in the early HCC patients.

公开(公告)号：US10697971B2

公开(公告)日：2020-06-30

申请号：US15545552

申请日：2017-04-27

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Jong Shin Yoo ,  Kwang Hoe Kim ,  Jin Young Kim ,  Ju Yeon Lee

IPC: G01N33/574 ,  G01N33/68

Abstract: The present invention relates to a diagnosis method of liver cancer using mass spectrometry of α-fetoprotein derived glycopeptide. Particularly, according to the AFP glycopeptide analysis method of the invention, fucosylation rate of the glycopeptide having the sequence composed of Val-Asn-Phe-Thr-Glu-Ile-Gln-Lys is analyzed to diagnose liver cancer in the early developmental grade. In particular, fucosylation rate is higher in the liver cancer patients than in other liver disease patients, so that the comparison of the fucosylation rate can be useful to diagnose or distinguish liver cancer from other liver diseases in the early HCC patients.