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公开(公告)号：US11215620B2
公开(公告)日：2022-01-04
申请号：US16296154
申请日：2019-03-07
Applicant: Korea Basic Science Institute
Inventor： Jin Young Kim , Gun Wook Park , Eun Sun Ji , Jong Shin Yoo
Abstract: The preset invention relates to a high resolution mass spectrometry based novel bioinformatics platform for the identification of glycation proteins and advanced glycation end-product. Particularly, the bioinformatics platform of the present invention facilitates an efficient and accurate investigation of quantitative changes of glycation proteins and advanced glycation end-products which are included in various types of samples but had not been informed yet, and uses a high resolution mass spectrometry, and thereby can be effectively used for the prediction or diagnosis of a disease including cancer by examining a disease marker in a sample.
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2.发明申请公开(公告)号：US20200018759A1
公开(公告)日：2020-01-16
申请号：US15545552
申请日：2017-04-27
Applicant: KOREA BASIC SCIENCE INSTITUTE
Inventor： Jong Shin Yoo , Kwang Hoe Kim , Jin Young Kim , Ju Yeon Lee
IPC: G01N33/574 , G01N33/68
Abstract: The present invention relates to a diagnosis method of liver cancer using mass spectrometry of α-fetoprotein derived glycopeptide. Particularly, according to the AFP glycopeptide analysis method of the invention, fucosylation rate of the glycopeptide having the sequence composed of Val-Asn-Phe-Thr-Glu-Ile-Gln-Lys is analyzed to diagnose liver cancer in the early developmental grade. In particular, fucosylation rate is higher in the liver cancer patients than in other liver disease patients, so that the comparison of the fucosylation rate can be useful to diagnose or distinguish liver cancer from other liver diseases in the early HCC patients.
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3.发明授权公开(公告)号：US11181531B2
公开(公告)日：2021-11-23
申请号：US16078333
申请日：2017-12-15
Applicant: Korea Basic Science Institute
Inventor： Gun Wook Park , Jong Shin Yoo , Jin Young Kim , Ju Yeon Lee , Hyun Kyoung Lee
Abstract: The present invention relates to a bioinformation processing analysis method for the identification and quantification of O-linked glycopeptide using high resolution mass spectrum. Particularly, according to the bioinformation processing analysis method of the present invention, the quantitative changes of O-linked glycopeptide containing non-informed sugar chains included in various samples can be efficiently and accurately analyzed; the prediction or diagnosis of disease including cancer can be made easy by using a high resolution mass spectrometer; or the investigation of O-linked glycopeptide structure of a therapeutic glycoprotein can be efficiently achieved.
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Patent Agency Ranking
公开(公告)号：US20150147765A1
公开(公告)日：2015-05-28
申请号：US14303939
申请日：2014-06-13
Applicant: Korea Basic Science Institute
Inventor： Yeong Hee Ahn , Jong Shin Yoo , Eun Sun Ji
IPC: G01N33/68
CPC classification number: G01N33/6818 , G01N33/57484
Abstract: The present invention relates to a method for diagnosing cancer using information on the aberrant glycosylation of a glycoprotein involved in cancer progress. More particularly, the present invention relates to a cancer diagnosis peptide marker which is screened by the steps of: separating a glycoprotein aberrantly glycosylated according to the occurrence and progress of cancer from the blood of a lung cancer patient by using lectin; and selecting a marker peptide produced by the hydrolysis of the glycoprotein isolated by lectin. The marker peptide can be effectively used as a cancer diagnosis marker and for the diagnosis of cancer.
Abstract translation: 本发明涉及使用涉及癌症进展的糖蛋白异常糖基化的信息来诊断癌症的方法。 更具体地，本发明涉及通过以下步骤进行筛选的癌症诊断肽标记：通过使用凝集素从根据癌症患者的血液的癌症的发生和进展而异糖基化的糖蛋白分离; 并选择由凝集素分离的糖蛋白的水解产生的标记肽。 标记肽可以有效地用作癌症诊断标记物和用于诊断癌症。
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5.发明授权公开(公告)号：US10697971B2
公开(公告)日：2020-06-30
申请号：US15545552
申请日：2017-04-27
Applicant: KOREA BASIC SCIENCE INSTITUTE
Inventor： Jong Shin Yoo , Kwang Hoe Kim , Jin Young Kim , Ju Yeon Lee
IPC: G01N33/574 , G01N33/68
Abstract: The present invention relates to a diagnosis method of liver cancer using mass spectrometry of α-fetoprotein derived glycopeptide. Particularly, according to the AFP glycopeptide analysis method of the invention, fucosylation rate of the glycopeptide having the sequence composed of Val-Asn-Phe-Thr-Glu-Ile-Gln-Lys is analyzed to diagnose liver cancer in the early developmental grade. In particular, fucosylation rate is higher in the liver cancer patients than in other liver disease patients, so that the comparison of the fucosylation rate can be useful to diagnose or distinguish liver cancer from other liver diseases in the early HCC patients.
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公开(公告)号：US20190285645A1
公开(公告)日：2019-09-19
申请号：US16296154
申请日：2019-03-07
Applicant: Korea Basic Science Institute
Inventor： Jin Young Kim , Gun Wook Park , Eun Sun Ji , Jong Shin Yoo
Abstract: The preset invention relates to a high resolution mass spectrometry based novel bioinformatics platform for the identification of glycation proteins and advanced glycation end-product. Particularly, the bioinformatics platform of the present invention facilitates an efficient and accurate investigation of quantitative changes of glycation proteins and advanced glycation end-products which are included in various types of samples but had not been informed yet, and uses a high resolution mass spectrometry, and thereby can be effectively used for the prediction or diagnosis of a disease including cancer by examining a disease marker in a sample.
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7.发明授权Bioinformatics platform for high-throughput identification and quantification of N—glycopeptide 有权用于高通量鉴定和定量的N-糖肽的生物信息学平台公开(公告)号：US09436797B2
公开(公告)日：2016-09-06
申请号：US13884233
申请日：2013-01-22
Applicant: Korea Basic Science Institute
Inventor： Gun Wook Park , Jong Shin Yoo , Jin Young Kim , Ju Yeon Lee , Hyun Kyoung Lee , Hyun Joo An , Jae-Han Kim
CPC classification number: G06F19/16 , C12Q1/37 , G01N30/86 , G01N33/6848 , G01N2030/8813 , G01N2030/8831 , G01N2400/00 , G01N2440/38 , G01N2560/00 , G01N2570/00 , H01J49/0027 , H01J49/0036 , H01J49/004
Abstract: The present invention relates to a more efficient and accurate method for the identification and quantification of comparatively low abundant glycopeptides, compared with general peptides, using mass spectrum obtained by using high resolution mass spectrometer. Therefore, the method of the present invention can be effectively used for the techniques for identification of biotherapeutics and diagnosis of cancer or disease by screening glycopeptide, the disease marker (Biomarker), from various samples.
Abstract translation: 本发明涉及使用通过使用高分辨率质谱仪获得的质谱，与一般肽相比，用于鉴定和定量相对低丰度糖肽的更有效和准确的方法。 因此，通过从各种样品中筛选糖肽（疾病标记物（Biomarker）），本发明的方法可以有效地用于识别生物治疗剂和癌症或疾病的诊断技术。
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8.发明申请Bioinformatics Platform for High-Throughput Identification and Quantification of N--Glycopeptide 有权用于高通量鉴定和定量的N-糖肽的生物信息学平台公开(公告)号：US20150186595A1
公开(公告)日：2015-07-02
申请号：US13884233
申请日：2013-01-22
Applicant: Korea Basic Science Institute
Inventor： Gun Wook Park , Jong Shin Yoo , Jin Young Kim , Ju Yeon Lee , Hyun Kyoung Lee , Hyun Joo An , Jae-Han Kim
CPC classification number: G06F19/16 , C12Q1/37 , G01N30/86 , G01N33/6848 , G01N2030/8813 , G01N2030/8831 , G01N2400/00 , G01N2440/38 , G01N2560/00 , G01N2570/00 , H01J49/0027 , H01J49/0036 , H01J49/004
Abstract: The present invention relates to a more efficient and accurate method for the identification and quantification of comparatively low abundant glycopeptides, compared with general peptides, using mass spectrum obtained by using high resolution mass spectrometer. Therefore, the method of the present invention can be effectively used for the techniques for identification of biotherapeutics and diagnosis of cancer or disease by screening glycopeptide, the disease marker (Biomarker), from various samples.
Abstract translation: 本发明涉及使用通过使用高分辨率质谱仪获得的质谱，与一般肽相比，用于鉴定和定量相对低丰度糖肽的更有效和准确的方法。 因此，通过从各种样品中筛选糖肽（疾病标记物（Biomarker）），本发明的方法可以有效地用于识别生物治疗剂和癌症或疾病的诊断技术。
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