公开(公告)号：US20240285717A1

公开(公告)日：2024-08-29

申请号：US18435415

申请日：2024-02-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Myung Suk KIM ,  Sang Hoon JUNG ,  Hye Jin KO ,  Tam Thi LE ,  Ngoc Bao NGUYEN ,  Wook Bin LEE

IPC: A61K36/752 ,  A61P21/00

CPC classification number: A61K36/752 ,  A61P21/00

Abstract: The present invention relates to a composition for the prevention or treatment of a muscle disease, comprising an extract of Ponciri Fructus. The extract of the present invention has the effect of increasing the expression of genes related to myotube cell differentiation and/or athletic performance, increasing muscle weight, and/or improving athletic performance.

公开(公告)号：US20230250424A1

公开(公告)日：2023-08-10

申请号：US16761151

申请日：2018-10-19

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

Inventor： Sang Hoon JUNG ,  Young-Joo KIM ,  Dae-geun SONG ,  Young Nyun PARK ,  Jeong Eun YOO ,  Hyung Jin RHEE ,  Youngsic JEON

IPC: C12N15/113 ,  A61P35/00 ,  A61P1/16

CPC classification number: C12N15/113 ,  A61P1/16 ,  A61P35/00 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/14 ,  C12N2310/127 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2310/3181

Abstract: In the present specification, on the basis of the correlation between prospero homeobox protein 1 (PROX1) and telomerase reverse transcriptase (TERT), a composition for regulating expression of TERT, a method for screening a TERT expression regulator, a composition for diagnosing a TERT expression status, a diagnostic kit, a method for providing information for diagnosis, or a method for providing information for cancer diagnosis are disclosed. Specifically, in one aspect, the PROX1 of the present disclosure may bind to a TERT promoter, in particular a mutant TERT promoter in which base substitution occurs at the -124 or -146 bp position to regulate the expression of TERT, and the expression of TERT in non-hepatitis B virus-associated liver cancer can be inhibited specifically among liver cancers.

公开(公告)号：US20240216458A1

公开(公告)日：2024-07-04

申请号：US18540186

申请日：2023-12-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Myung Suk KIM ,  Sang Hoon JUNG ,  Wook Bin LEE ,  Tam Thi LE ,  Tae Kyeom KANG

IPC: A61K36/482 ,  A61K31/05 ,  A61K31/085 ,  A61K31/122 ,  A61K31/192 ,  A61K31/216 ,  A61K31/353 ,  A61K31/7048 ,  A61P37/08

CPC classification number: A61K36/482 ,  A61K31/05 ,  A61K31/085 ,  A61K31/122 ,  A61K31/192 ,  A61K31/216 ,  A61K31/353 ,  A61K31/7048 ,  A61P37/08 ,  A61K2236/333

Abstract: The present invention relates to a composition for the prevention, improvement or treatment of allergic diseases containing a Cassia mimosoides L. extract as an active ingredient, and more specifically, to a composition for the prevention, improvement or treatment of allergic diseases containing an ethanol extract of Cassia mimosoides L. as an active ingredient. In the present invention, the effect of Cassia mimosoides L. extract in treating allergic respiratory diseases was confirmed in an animal model of allergic asthma, and the anti-allergic effect of the compounds isolated from an ethanol extract of Cassia mimosoides L. was confirmed. Therefore, Cassia mimosoides L. extract of the present invention can be useful as a composition for preventing, improving, or treating allergic respiratory diseases, particularly allergic asthma or allergic bronchitis.

公开(公告)号：US20240424043A1

公开(公告)日：2024-12-26

申请号：US18749263

申请日：2024-06-20

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Myung Suk KIM ,  Sang Hoon JUNG ,  Hye Jin KO ,  Tam Thi LE

IPC: A61K36/25 ,  A61K31/05 ,  A61K31/085 ,  A61K31/122 ,  A61K31/192 ,  A61K31/216 ,  A61K31/7048 ,  A61P21/00 ,  A61P43/00

Abstract: The present invention relates to a composition for preventing or treating muscle disease comprising an extract of Aralia Elata. The Aralia Elata extract of the present invention has the effect of improving grip strength, increasing muscle weight, and improving exercise performance.

公开(公告)号：US20180059075A1

公开(公告)日：2018-03-01

申请号：US15685510

申请日：2017-08-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Yongsoo CHOI ,  Jeongsook SHIN ,  Cheol-Ho PAN ,  Sang Min KIM ,  Jung-Seok YANG ,  Kyungsu KANG ,  Sang Hoon JUNG

IPC: G01N30/72 ,  G01N30/06

CPC classification number: G01N30/7233 ,  G01N30/06 ,  G01N2030/027 ,  G01N2030/067 ,  G01N2030/8818

Abstract: Provided is an amine group-derivatized composition including a Boc compound for liquid chromatography-mass spectrometry (LC-MS) analysis, and when the amine group-derivatized composition is used in analysis using reverse-phase LC-MS, it is possible to effectively analyze compounds including an amine group and an amino acid at a low cost in a short time.

公开(公告)号：US20160310551A1

公开(公告)日：2016-10-27

申请号：US15132899

申请日：2016-04-19

Applicant: Korea Institute of Science and Technology

Inventor： Sang Hoon JUNG ,  Kyung A KIM ,  Suk-Woo KANG ,  Joo Young LEE ,  Hong Ryul AHN ,  Youngwoo SONG

IPC: A61K36/44 ,  A61K9/00

CPC classification number: A61K36/44 ,  A23L33/105 ,  A61K9/0053

Abstract: Disclosed is a method for preventing, improving and/or treating cornea damage or a corneal disease, including administering an effective amount of an extract of a persimmon tree for preventing, improving or treating cornea damage to a subject in need thereof. The extract may be a persimmon leaf extract and the extract is effective in suppressing inflammation of the cornea and protecting corneal cells.

Abstract translation: 公开了一种预防，改善和/或治疗角膜损伤或角膜疾病的方法，包括给予有效量的柿树提取物以预防，改善或治疗有需要的受试者的角膜损伤。 提取物可以是柿叶提取物，提取物可有效抑制角膜炎症和保护角膜细胞。