公开(公告)号：US12131893B1

公开(公告)日：2024-10-29

申请号：US18497574

申请日：2023-10-30

Applicant: CHINA TOBACCO YUNNAN INDUSTRIAL CO., LTD.

Inventor： Ruizhi Zhu ,  Xiaoxi Si ,  Yanqun Xu ,  Zhihua Liu ,  Ji Yang ,  Wei Jiang ,  Chunbo Liu ,  Fengmei Zhang ,  Zhenjie Li ,  Shiyun Tang

IPC: G01N30/86 ,  G01N1/10 ,  G16C20/20 ,  H01J49/00 ,  H01J49/42 ,  G01N30/02 ,  G16C20/30

CPC classification number: H01J49/0036 ,  G01N1/10 ,  G01N30/8631 ,  G01N30/8679 ,  H01J49/425 ,  G01N2001/1006 ,  G01N2030/027 ,  G16C20/20 ,  G16C20/30

Abstract: A method of identifying tobacco carbonyl components using non-targeted mass spectrometry is disclosed, which includes the following steps: (1) preparing a tobacco sample extract; (2) derivatizing (part of) the sample/extract with 2,4-dinitrophenylhydrazine (DNPH); (3) derivatizing (another part of) the sample/extract with DNPH-d3; (4) mixing the derivatized tobacco samples; (5) preparing blank samples; (6) performing ultra performance liquid chromatography (UPLC) and ion trap (Orbitrap) high resolution mass spectrometry (HRMS) on the (derivatized) tobacco samples; (7) processing the LC-MS data; (8) filtering the mass spectrometric characteristic data to retain final chromatographic peaks; and (9) structurally annotating or identifying the retained final chromatographic peaks to obtain the tobacco carbonyl components. The method quickly removes noise or interfering components in the original data set by multiple filtering of the mass spectrometry characteristic data, and enables obtaining composition information of aldehyde and ketone chemical components in cigarettes.

公开(公告)号：US12129224B2

公开(公告)日：2024-10-29

申请号：US17435731

申请日：2020-03-05

Applicant: ITALFARMACO SPA

Inventor： Stefano Turchetta ,  Maurizio Zenoni ,  Elio Ullucci ,  Stefania Cocciolo ,  Giorgio Berardi ,  Nakia Maulucci

IPC: C07C271/28 ,  B01J20/286 ,  C07C269/06 ,  C07C269/08 ,  G01N30/02

CPC classification number: C07C271/28 ,  B01J20/286 ,  C07C269/06 ,  C07C269/08 ,  G01N2030/027 ,  C07C269/06 ,  C07C271/28 ,  C07C269/08 ,  C07C271/28

Abstract: A process for obtaining {{6-[(diethylamino)methyl]naphthalen-2-yl}methyl[4-(hydroxycarbamoyl)phenyl]carbamate and/or pharmaceutically acceptable salts thereof having high purity is described. This process allows to obtain a product having an amount of any single unknown impurity equal to or less than 0.10%, as well as a product having a purity greater than 99.5%, preferably equal to or greater than 99.6%.
An HPLC method for determining the purity of the product and possible impurities thereof is also described.

公开(公告)号：US20240345068A1

公开(公告)日：2024-10-17

申请号：US18644702

申请日：2024-04-24

Applicant: ALCHEME BIO INC.

Inventor： Vanessa Small

IPC: G01N33/50 ,  G01N30/02 ,  G01N30/86

CPC classification number: G01N33/5041 ,  G01N30/8651 ,  G01N33/5097 ,  G01N2030/025 ,  G01N2030/027

Abstract: Systems for cellular attribute alignment of a base cellular agriculture product with a reference product include first data including a compositional profile of a reference product having a cellular attribute of interest, second data including a compositional profile of a base cellular agriculture product produced to emulate the cellular attribute of interest of the reference product, and processing circuitry configured to identify one or more target compounds in the reference product affecting the attribute of interest, determine at least one compositional gap in the base cellular agriculture product compared to the reference product, and provide an adjustment to a manufacturing process or a manufacturing component for the base cellular agriculture product to reduce or eliminate the at least one compositional gap in the base cellular agriculture product affecting the attribute of interest to produce an enhanced cellular agriculture product. Methods and cellular agriculture products made therefrom are also provided.

公开(公告)号：US20240345048A1

公开(公告)日：2024-10-17

申请号：US18673492

申请日：2024-05-24

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Nathan L. MAO ,  Scott CARVER ,  Bernhard SCHILLING ,  Eric SHIERLY

IPC: G01N30/88 ,  B01D15/20 ,  B01D15/32 ,  B01D15/36 ,  B01D15/38 ,  B01D15/42 ,  C07K1/16 ,  C07K14/475 ,  G01N30/02 ,  G01N30/56 ,  G01N30/74 ,  G01N30/86

CPC classification number: G01N30/88 ,  B01D15/3804 ,  B01D15/424 ,  C07K1/16 ,  G01N30/74 ,  G01N30/8651 ,  G01N30/8675 ,  B01D15/206 ,  B01D15/327 ,  B01D15/363 ,  C07K14/475 ,  G01N2030/027 ,  G01N30/56 ,  G01N2030/562 ,  G01N2030/889

Abstract: The disclosure provides systems and methods useful for predicting or detecting a malfunction in a chromatography process in real-time. In some embodiments, the disclosure provides systems and methods for detecting an atypical profile in a process chromatogram in ion-exchange chromatography of a biologic product.

公开(公告)号：US20240345025A1

公开(公告)日：2024-10-17

申请号：US18750532

申请日：2024-06-21

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Rachel MULLEN ,  Clare RYAN ,  Seamus O'CONNOR ,  Stacey HELMING

IPC: G01N27/447 ,  G01N30/02 ,  G01N30/72 ,  G01N30/86 ,  G16C20/20

CPC classification number: G01N27/44795 ,  G01N30/72 ,  G01N30/8624 ,  G16C20/20 ,  G01N2030/027

Abstract: The disclosure relates to methods of characterizing ampholyte compositions suitable for downstream applications such as capillary isoelectric focusing using liquid-chromatography-mass spectrometry.

公开(公告)号：US20240337628A1

公开(公告)日：2024-10-10

申请号：US18297235

申请日：2023-04-07

Applicant: ECI TECHNOLOGY, INC.

Inventor： Jake Zhu ,  Eugene Shalyt ,  Mike Macewan

IPC: G01N30/02 ,  C25D3/38 ,  C25D21/12 ,  G01N30/74

CPC classification number: G01N30/02 ,  C25D3/38 ,  C25D21/12 ,  G01N30/74 ,  G01N2030/027

Abstract: The present subject matter relates to techniques for quantitation of an unstable or breakdown product generated from a raw material, e.g., bis (3-sulfopropyl)-disulfide (SPS) in acid copper plating baths. The disclosed techniques include spiking oxidant into the copper bath solution and analyzing HPLC response to quantify the absolute value of the unstable or breakdown with accuracy and precision.

公开(公告)号：US12111297B2

公开(公告)日：2024-10-08

申请号：US17962474

申请日：2022-10-08

Applicant: SHIMADZU CORPORATION

Inventor： Yuka Fujito ,  Logan Miller

IPC: G01N30/38 ,  B01D15/18 ,  G01N30/02 ,  G01N30/22 ,  G01N30/24 ,  G01N30/26 ,  G01N30/86 ,  G01N30/16 ,  G01N30/20 ,  G01N30/88

CPC classification number: G01N30/38 ,  B01D15/18 ,  G01N30/22 ,  G01N30/8641 ,  G01N2030/027

Abstract: A controller of a liquid chromatograph is configured to execute, as an analysis operation in an analysis unit, a sample injection step of bringing a high-pressure valve into a loading state, sucking a sample from a tip of a needle to hold a sample in a sampling channel, then connecting the sampling channel to an injection port and bringing the high-pressure valve into an injecting state, and supplying a mobile phase from a liquid supplier, thereby injecting a sample held in the sampling channel into an analysis channel, and an analysis step of separating components of a sample injected into the analysis channel in a separation column by bringing the high-pressure valve in the loading state and supplying the mobile phase from the liquid supplier after the sample injection step is ended. The controller is configured to execute, as the analysis operation, a system cleaning step of cleaning a liquid flowing route.

公开(公告)号：US20240327337A1

公开(公告)日：2024-10-03

申请号：US18622234

申请日：2024-03-29

Applicant: Noven Pharmaceuticals, Inc.

Inventor： Deboprosad Mondal

IPC: C07C269/08 ,  G01N30/02 ,  G01N30/06 ,  G01N30/64

CPC classification number: C07C269/08 ,  G01N30/06 ,  G01N30/64 ,  G01N2030/027 ,  G01N2030/067 ,  G01N2030/645

Abstract: Described herein are the amphetamine-related compounds amphetamine carbamate (amphetammonium-amphetacarbamate) and amphetacarbamate, methods of making them, methods for detecting or quantitatively determining the amount of amphetacarbamate or amphetamine carbamate in a compositions, and ion chromatography columns useful in such methods.

公开(公告)号：US12105064B2

公开(公告)日：2024-10-01

申请号：US17788762

申请日：2020-04-27

Applicant: SHIMADZU CORPORATION

Inventor： Hiroshi Tanaka ,  Mikoto Taki

IPC: G01N30/32 ,  B01D15/36 ,  B01D61/46 ,  B01D61/54 ,  G01N30/02

CPC classification number: G01N30/32 ,  B01D15/361 ,  B01D61/46 ,  B01D61/54 ,  G01N2030/027 ,  G01N2030/326 ,  G01N2030/328

Abstract: A suppressor device for an ion chromatograph is provided between a separation column and a detector of an ion chromatograph. An electrodialysis suppressor includes a first flow path to which an eluate flowing from the separation column is supplied, a second flow path to which a regeneration liquid is supplied, an ion exchange membrane provided between the first flow path and the second flow path and an electrode to which a voltage is applied. A power supply circuit that applies a voltage to the electrode is turned off in a case in which an eluate is not supplied to the first flow path of the electrodialysis suppressor.

公开(公告)号：US20240319149A1

公开(公告)日：2024-09-26

申请号：US18607434

申请日：2024-03-16

Applicant: SHIMADZU CORPORATION

Inventor： Shinji TANAKA

IPC: G01N30/60 ,  G01N30/02 ,  G01N30/38

CPC classification number: G01N30/6065 ,  G01N30/38 ,  G01N2030/027

Abstract: A pipe for a chromatograph includes a thin portion and a thick portion. The thin portion extends in one direction. The thick portion is located at an end portion of the thin portion in the one direction. The thin portion and the thick portion are integrally formed of a single member. The outer diameter of the thin portion is smaller than the outer diameter of the thick portion. The pipe is used in a chromatograph.