公开(公告)号：US10220043B2

公开(公告)日：2019-03-05

申请号：US15534069

申请日：2015-12-11

Applicant: KOWA COMPANY, LTD.

Inventor： Isamu Sawai

IPC: A61K31/551 ,  A61K47/22 ,  A61K9/08 ,  A61K31/498 ,  A61K9/00 ,  A61K31/10 ,  A61K31/473 ,  A61K31/5513 ,  A61P27/06

Abstract: A technique is provided for suppressing the crystal precipitation of an aqueous composition containing a halogenated isoquinoline derivative during low-temperature preservation. An aqueous composition comprising a compound represented by Formula (1): wherein x represents a halogen atom, or a salt thereof, or a solvate of the compound or the salt thereof, and brimonidine or a salt thereof.

公开(公告)号：US09616069B2

公开(公告)日：2017-04-11

申请号：US15060927

申请日：2016-03-04

Applicant: KOWA COMPANY, LTD.

Inventor： Isamu Sawai

IPC: A61K31/551 ,  A61K9/08 ,  A61K47/02 ,  A61K45/06 ,  A61K31/18 ,  A61K31/433 ,  A61K31/382 ,  A61K31/542 ,  A61K9/00

CPC classification number: A61K31/551 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/18 ,  A61K31/382 ,  A61K31/433 ,  A61K31/542 ,  A61K45/06 ,  A61K47/02 ,  A61K2300/00

Abstract: Provided is a technology for suppressing discoloration of a halo-isoquinoline derivative-containing aqueous composition during high-temperature storage. Provided is an aqueous composition containing a compound of formula (1): wherein X is a halogen atom, a salt of the compound, or a solvate of the compound or the salt; and a carbonic anhydrase inhibitor.