公开(公告)号：US09682942B2

公开(公告)日：2017-06-20

申请号：US14784147

申请日：2014-05-30

Applicant: KOWA COMPANY, LTD.

Inventor： Koichi Yamazaki ,  Kennosuke Matsuda ,  Taichi Kusakabe ,  Tadaaki Ohgiya ,  Kimiyuki Shibuya

IPC: A01N43/54 ,  A61K31/505 ,  C07D239/47

CPC classification number: C07D239/47 ,  C07B2200/13

Abstract: It is an object of the present invention to provide a novel form of (S)-trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid, which is useful for preventing and/or treating diseases such as dyslipidemia.(S)-trans-{4-[({2-[({1-[3,5-bis(Trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid hydrochloride.

公开(公告)号：US20140221390A1

公开(公告)日：2014-08-07

申请号：US14162181

申请日：2014-01-23

Applicant: Kowa Company, Ltd.

Inventor： Haruki Shibata ,  Yasunobu Yoshinaka ,  Kimiyuki Shibuya

IPC: C07D401/12

CPC classification number: C07D401/12 ,  A61K31/496

Abstract: Provided is a compound useful in the prevention and treatment of non-alcoholic steatohepatitis. A prophylactic and/or therapeutic agent for non-alcoholic steatohepatitis which contains, as the active ingredient, 2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide, an acid-addition salt thereof, or a solvate of the same.

Abstract translation: 提供了用于预防和治疗非酒精性脂肪性肝炎的化合物。 含有作为活性成分的2- [4- [2-（苯并咪唑-2-基硫基）乙基]哌嗪-1-基] -N- [2,4（ⅰ））的非酒精性脂肪性肝炎的预防和/或治疗剂 - 双（甲硫基）-6-甲基-3-吡啶基]乙酰胺，其酸加成盐或其溶剂合物。

公开(公告)号：US20140303198A1

公开(公告)日：2014-10-09

申请号：US14358399

申请日：2012-11-28

Applicant: KOWA COMPANY, LTD.

Inventor： Takeshi Murakami ,  Kentaro Murakami ,  Tadaaki Ohgiya ,  Kimiyuki Shibuya

IPC: A61K31/505 ,  A61K31/421

CPC classification number: A61K31/505 ,  A61K31/421 ,  C07D239/47 ,  C07D263/24

Abstract: Provided is an agent for treating and/or preventing obesity. An agent for suppressing expression of NPC1L1 (Niemann-Pick disease, type C1, gene-like 1) and/or LIPG (Lipase, endothelial) mRNA, and an agent for preventing and/or treating obesity, each comprising, as an active ingredient, a compound having CETP inhibitory activity, or a salt thereof, or a solvate thereof.

Abstract translation: 本发明提供治疗和/或预防肥胖症的药剂。 抑制NPC1L1（Niemann-Pick疾病，C1型，基因样1）和/或LIPG（脂肪酶，内皮）mRNA表达的抑制剂和用于预防和/或治疗肥胖症的药剂，各自包含作为活性成分 ，具有CETP抑制活性的化合物或其盐或其溶剂合物。