公开(公告)号：US20210047341A1

公开(公告)日：2021-02-18

申请号：US16976463

申请日：2019-02-26

Applicant: KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Min XU ,  Haoyang YUAN ,  Haizhou LI ,  Yingjun ZHANG ,  Chongren YANG

IPC: C07D493/10

Abstract: Disclosed are a sesquiterpene derivative and a use of the same in preparation of a medicament for treating hepatitis B diseases. The sesquiterpene derivative has the effects of down-regulating the hepatocyte nuclear factor 4α (HNF-4α) and significantly inhibiting the hepatitis B virus, and can be used for preventing and/or treating and/or assisting in the treatment of liver system diseases and symptoms caused by the hepatitis B virus, and can be used as a hepatic protective agent. In addition, the synthetic sesquiterpene derivative can also be used for preventing or treating viral infectious diseases and conditions resulting from the influenza virus, coxsackievirus, herpes simplex virus, etc. Also involved is the preparation of the synthetic sesquiterpene derivative, which acts as a raw material, in clinically acceptable pharmaceutical formulations, such as oral dosage forms such as tablets, capsules and drop pills or non-oral dosage forms such as inhalants and injections.

公开(公告)号：US20240270754A1

公开(公告)日：2024-08-15

申请号：US18625188

申请日：2024-04-02

Applicant: KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Min XU ,  Shaoxing DAI

IPC: C07D493/10 ,  A61K31/35 ,  A61P31/14

CPC classification number: C07D493/10 ,  A61K31/35 ,  A61P31/14

Abstract: A sesquiterpenoid derivative and use thereof in preparing a broad-spectrum antiviral drug provided. The sesquiterpenoid derivative can stimulate heterogeneous nuclear ribonucleoprotein A2/B1, activate the cell signal pathway of TANK-binding kinase 1-interferon regulatory factor 3, and increase the expression and secretion of endogenous type I interferon. As a result, it can inhibiting various viruses and can be used as a broad-spectrum antiviral drug for preventing or treating various viral infectious diseases and symptoms, including Covid-19, vesicular stomatitis virus VSV-G, AIDS virus, hepatitis C virus, Japanese encephalitis virus, influenza virus, poliovirus, Coxsackie virus, dengue virus, rotavirus, tobacco mosaic virus, measles virus, mumps virus, Ebola virus, Marburg virus, herpes virus and adenovirus. Sesquiterpenoid derivatives can be made as a raw material into oral dosage form such as tablet, capsule and dripping pill, or clinically acceptable pharmaceutical preparation such as inhalant and injection.