公开(公告)号：US20240270754A1

公开(公告)日：2024-08-15

申请号：US18625188

申请日：2024-04-02

Applicant: KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Min XU ,  Shaoxing DAI

IPC: C07D493/10 ,  A61K31/35 ,  A61P31/14

CPC classification number: C07D493/10 ,  A61K31/35 ,  A61P31/14

Abstract: A sesquiterpenoid derivative and use thereof in preparing a broad-spectrum antiviral drug provided. The sesquiterpenoid derivative can stimulate heterogeneous nuclear ribonucleoprotein A2/B1, activate the cell signal pathway of TANK-binding kinase 1-interferon regulatory factor 3, and increase the expression and secretion of endogenous type I interferon. As a result, it can inhibiting various viruses and can be used as a broad-spectrum antiviral drug for preventing or treating various viral infectious diseases and symptoms, including Covid-19, vesicular stomatitis virus VSV-G, AIDS virus, hepatitis C virus, Japanese encephalitis virus, influenza virus, poliovirus, Coxsackie virus, dengue virus, rotavirus, tobacco mosaic virus, measles virus, mumps virus, Ebola virus, Marburg virus, herpes virus and adenovirus. Sesquiterpenoid derivatives can be made as a raw material into oral dosage form such as tablet, capsule and dripping pill, or clinically acceptable pharmaceutical preparation such as inhalant and injection.