公开(公告)号：US20050107471A1

公开(公告)日：2005-05-19

申请号：US10966408

申请日：2004-10-14

申请人： Karl Gierskcky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjorseth ,  Jo Klaveness ,  Nils Nilsen ,  Jon Braenden ,  Aslak Godal

发明人： Karl Gierskcky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjorseth ,  Jo Klaveness ,  Nils Nilsen ,  Jon Braenden ,  Aslak Godal

IPC分类号： A61K41/00 ,  A61K49/00 ,  C07C229/22 ,  A61K31/22

CPC分类号： C07C229/22 ,  A61K41/0061 ,  A61K49/0021 ,  A61K49/0052

摘要： The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

摘要翻译： 本发明涉及作为5-氨基乙酰丙酸的酯或其药学上可接受的盐的化合物，包括式（I）的化合物R 2 N 2 CH 2 其中R 1可以表示任选取代的烷基，其中R 1表示任选被取代的烷基， 羟基，烷氧基，酰氧基，烷氧基羰基氧基，氨基，芳基，氧代或氟基团，且任选被氧，氮，硫或磷原子间隔; R 2表示氢原子或基团R > 1 ，并且两个R 2个基团可以相同或不同），以及它们在诊断和光化学治疗身体的外部或内部表面的障碍或异常中的用途，以及产品和 用于执行本发明的试剂盒。

公开(公告)号：US20050031541A1

公开(公告)日：2005-02-10

申请号：US10818917

申请日：2004-04-05

申请人： Karl Gierskcky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjorseth

发明人： Karl Gierskcky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjorseth

IPC分类号： A61K41/00 ,  A61K49/00 ,  C07C229/22

CPC分类号： A61K41/0061 ,  A61K49/0021 ,  C07C229/22

摘要： The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2-CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

摘要翻译： 本发明涉及作为5-氨基乙酰丙酸的酯或其药学上可接受的盐的化合物，包括式（I）R 22 N-CH 2 COCH 2 -CH 2 CO-OR 1的化合物（其中R 1可以表示任选被羟基，烷氧基，酰氧基，烷氧基羰基氧基， 氨基，芳基，氧代或氟基团，并且任选地被氧，氮，硫或磷原子间隔;并且R 2表示氢原子或基团R 1，并且两个R 2基团可以相同或不同），以及它们在诊断和 身体的外表面或内表面的紊乱或异常的光化学疗法，以及用于实施本发明的产品和试剂盒。

公开(公告)号：US07247655B2

公开(公告)日：2007-07-24

申请号：US10410636

申请日：2003-04-09

申请人： Karl E. Gierskcky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjorseth

发明人： Karl E. Gierskcky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjorseth

IPC分类号： A61K31/22 ,  C07C229/00 ,  B65D69/00

CPC分类号： A61K49/0021 ,  A61K31/22 ,  A61K41/0061 ,  C07C229/22 ,  Y10S514/863 ,  Y10S514/947

摘要： The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

摘要翻译： 本发明涉及作为5-氨基乙酰丙酸的酯或其药学上可接受的盐的化合物，包括式（I）R 22 N-CH 2 COCH 2 -CH 2 CO-OR 1的化合物（其中R 1可以表示任选被羟基，烷氧基，酰氧基，烷氧基羰基氧基， 氨基，芳基，氧代或氟基团，并且任选地被氧，氮，硫或磷原子间隔;并且R 2表示氢原子或基团R 1，并且两个R 2基团可以相同或不同），以及它们在诊断和 身体的外表面或内表面的紊乱或异常的光化学疗法，以及用于实施本发明的产品和试剂盒。

公开(公告)号：US6034267A

公开(公告)日：2000-03-07

申请号：US913257

申请日：1997-12-05

申请人： Karl E. Gierskcky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjorseth

发明人： Karl E. Gierskcky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjorseth

IPC分类号： G01N33/50 ,  A61K31/215 ,  A61K41/00 ,  A61K49/00 ,  A61P35/00 ,  C07C227/18 ,  C07C229/22 ,  G01N33/15 ,  G01N33/58 ,  C07C229/00 ,  A61K31/195

CPC分类号： A61K49/0021 ,  A61K41/0061 ,  A61K49/0017 ,  C07C229/22 ,  Y10T436/145555

摘要： The invention provides a pharmaceutical compositions comprising a compound of formula I:R.sub.2.sup.2 N--CH.sub.2 COCH.sub.2 --CH.sub.2 CO--OR.sup.1(I)wherein, R.sup.1 and R.sup.2 have any of the values defined in the specification; or a salt thereof; and a pharmaceutically acceptable carrier or excipient. The invention also provides a method for the diagnosis or photochemotherapeutic treatment of disorders or abnormalities of external or internal surfaces of the body using such compounds or salts.

摘要翻译： PCT No.PCT / GB96 / 00553 Sec。 371 1997年12月5日第 102（e）日期1997年12月5日PCT 1996年3月8日PCT公布。 WO96 / 28412 PCT出版物 日本1996年9月19日本发明提供包含式I化合物：R 22 N-CH 2 COCH 2 -CH 2 CO-OR 1（I）的药物组合物，其中R1和R2具有说明书中定义的任何值; 或其盐; 和药学上可接受的载体或赋形剂。 本发明还提供了一种用于使用这些化合物或盐对身体的外表面或内表面的病症或异常进行诊断或光化学治疗性治疗的方法。

公开(公告)号：US06992107B1

公开(公告)日：2006-01-31

申请号：US09655570

申请日：2000-09-06

申请人： Karl E. Gierskcky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjorseth

发明人： Karl E. Gierskcky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjorseth

IPC分类号： A61K31/22 ,  A61K31/21 ,  C07C229/00 ,  B65D71/00

CPC分类号： C07C229/22 ,  A61K41/0061 ,  A61K49/0021 ,  A61K49/0052

摘要： The present invention provides a compound of formula I; R22N—CH2COCH2—CH2CO—OR1  (I) wherein R1 represents (a) an optionally substituted branched C6-30 alkyl group, comprising a straight chain C4-29 alkyl group, branched by substitution with one or more C1-6 alkyl groups, wherein said site of substitution is at C2 or a higher C atom, (b) a non-heteroaromatic aryl substituted alkyl group, wherein said aryl group is substituted, or (c) an alkoxy substituted alkyl group, wherein said alkoxy group is substituted by a methoxy group or an alkoxy group substituted with an alkoxy group, wherein in (a) and (b) said substituents are selected from hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo or fluoro groups, and said alkyl group is optionally interrupted or terminated by one or more —O—, NR3—, —S— or PR3— groups; R2, each of which may be the same or different, represents a hydrogen atom or a group R1, wherein R1 represents (a) an optionally substituted branched C5-30 alkyl group, comprising a straight chain C4-29 alkyl group, branched by substitution with one or more C1-6 alkyl groups, wherein said site of substitution is at C2 or a higher C atom, (b) a non-heteroaromatic aryl substituted alkyl group, wherein said aryl group is substituted, or (c) an alkoxy substituted alkyl group, wherein said alkoxy group is substituted by a methoxy group or an alkoxy group substituted with an alkoxy group, wherein in (a) and (b) said substituents are selected from hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo or fluoro groups, and said alkyl group is optionally interrupted or terminated by one or more —O—, NR3—, —S— or PR3— groups; and R3 represents a hydrogen or C1-6 alkyl group, and salts thereof for use in photochemotherapy or diagnosis. Pharmaceutical compositions comprising said compound, methods of diagnosis or photochemotherapy using said compound and related compounds and compositions, and products and kits comprising said compounds are also provided.

公开(公告)号：US07335684B2

公开(公告)日：2008-02-26

申请号：US11290275

申请日：2005-11-29

申请人： Karl E. Gierskcky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjorseth

发明人： Karl E. Gierskcky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjorseth

IPC分类号： A61K31/22 ,  C07C229/00

CPC分类号： A61K49/0021 ,  A61K31/22 ,  A61K41/0061 ,  C07C229/22 ,  Y10S514/863 ,  Y10S514/947

摘要： The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2-CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

摘要翻译： 本发明涉及作为5-氨基乙酰丙酸的酯或其药学上可接受的盐的化合物，包括式（I）R 22 N-CH 2 COCH 2 -CH 2 CO-OR 1的化合物（其中R 1可以表示任选被羟基，烷氧基，酰氧基，烷氧基羰基氧基， 氨基，芳基，氧代或氟基团，并且任选地被氧，氮，硫或磷原子间隔;并且R 2表示氢原子或基团R 1，并且两个R 2基团可以相同或不同），以及它们在诊断和 身体的外表面或内表面的紊乱或异常的光化学疗法，以及用于实施本发明的产品和试剂盒。

公开(公告)号：US07287646B2

公开(公告)日：2007-10-30

申请号：US10966408

申请日：2004-10-14

申请人： Karl E Gierskcky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjorseth ,  Jo Klaveness ,  Nils Nilsen ,  Jon Erik Braenden ,  Aslak Godal

发明人： Karl E Gierskcky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjorseth ,  Jo Klaveness ,  Nils Nilsen ,  Jon Erik Braenden ,  Aslak Godal

IPC分类号： B65D69/00 ,  A61K31/22 ,  C07C69/66

CPC分类号： C07C229/22 ,  A61K41/0061 ,  A61K49/0021 ,  A61K49/0052

摘要： The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

摘要翻译： 本发明涉及作为5-氨基乙酰丙酸的酯或其药学上可接受的盐的化合物，包括式（I）的化合物R 2 N 2 CH 2 其中R 1可以表示任选取代的烷基，其中R 1表示任选被取代的烷基， 羟基，烷氧基，酰氧基，烷氧基羰基氧基，氨基，芳基，氧代或氟基团，且任选被氧，氮，硫或磷原子间隔; R 2表示氢原子或基团R > 1 ，并且两个R 2个基团可以相同或不同），以及它们在诊断和光化学治疗身体的外部或内部表面的障碍或异常中的用途，以及产品和 用于执行本发明的试剂盒。

公开(公告)号：US20060084701A1

公开(公告)日：2006-04-20

申请号：US11290275

申请日：2005-11-29

申请人： Karl Gierskeky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjorseth

发明人： Karl Gierskeky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjorseth

IPC分类号： A61K31/22

CPC分类号： A61K49/0021 ,  A61K31/22 ,  A61K41/0061 ,  C07C229/22 ,  Y10S514/863 ,  Y10S514/947

摘要： The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2-CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

公开(公告)号：US06492420B2

公开(公告)日：2002-12-10

申请号：US09471620

申请日：1999-12-21

申请人： Karl E. Gierskcky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjorseth

发明人： Karl E. Gierskcky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjorseth

IPC分类号： A61K3744

CPC分类号： A61K49/0021 ,  A61K31/22 ,  A61K41/0061 ,  C07C229/22 ,  Y10S514/863 ,  Y10S514/947

摘要： The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

摘要翻译： 本发明涉及作为5-氨基乙酰丙酸的酯或其药学上可接受的盐的化合物，包括式（I）R 22 N-CH 2 COCH 2 -CH 2 CO-OR 1的化合物（其中R 1可以表示任选被羟基，烷氧基，酰氧基，烷氧基羰基氧基， 氨基，芳基，氧代或氟基团，并且任选地被氧，氮，硫或磷原子间隔;并且R 2表示氢原子或基团R 1，并且两个R 2基团可以相同或不同），以及它们在诊断和 身体的外表面或内表面的紊乱或异常的光化学疗法，以及用于实施本发明的产品和试剂盒。

公开(公告)号：US07530461B2

公开(公告)日：2009-05-12

申请号：US10818917

申请日：2004-04-05

申请人： Karl E. Gierskcky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjørseth

发明人： Karl E. Gierskcky ,  Johan Moan ,  Qian Peng ,  Harald Steen ,  Trond Warloe ,  Alf Bjørseth

IPC分类号： B65D69/00 ,  A61K31/22 ,  C07C229/00

CPC分类号： A61K41/0061 ,  A61K49/0021 ,  C07C229/22

摘要： The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2-CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.