-
公开(公告)号：US20080044391A2
公开(公告)日：2008-02-21
申请号：US10542104
申请日：2006-03-09
CPC分类号： C12N5/064 , A61K35/12 , A61K35/28 , A61K2035/122 , A61K2035/124 , A61K2039/515 , C12N5/0639
摘要： It is intended to provide expired dendritic cells having characteristics of the following (E1) to (E3): (E1) not shifting into a mature type due to an action of a natural immune stimulant or a permanent immune potentiator; (E2) having the same shape as immature DC; and (E3) expressing IL-10. It is intended to provide Permanently activated dendritic cells having the following characteristics: (M2-1) having projecting dendrites and forming aggregation clusters; (M2-2) being capable of activating unreacted cytotoxic T cells (CTL); (M2-3) having stable properties under the action of anti-CD40 monoclonal antibody; and (M2-4) showing a high expression level of at least one member selected from the group consisting of CD80, CD83 and CD86.
摘要翻译： 旨在提供具有以下（E1）至（E3）特征的过期树突状细胞：（E1）由于天然免疫刺激剂或永久性免疫增强剂的作用而不转化成成熟型; （E2）具有与未成熟DC相同的形状; 和（E3）表达IL-10。 旨在提供具有以下特征的永久活化的树突状细胞：（M2-1）具有突出的树突并形成聚集簇; （M2-2）能够活化未反应的细胞毒性T细胞（CTL）; （M2-3）在抗CD40单克隆抗体的作用下具有稳定的性质; 和（M2-4）表示选自CD80，CD83和CD86中的至少一种成员的高表达水平。
-
公开(公告)号：US20060147434A1
公开(公告)日：2006-07-06
申请号：US10542104
申请日：2004-01-16
CPC分类号： C12N5/064 , A61K35/12 , A61K35/28 , A61K2035/122 , A61K2035/124 , A61K2039/515 , C12N5/0639
摘要： It is intended to provide expired dendritic cells having characteristics of the following (E1) to (E3): (E1) not shifting into a mature type due to an action of a natural immune stimulant or a permanent immune potentiator;(E2) having the same shape as immature DC; and (E3) expressing IL-10. It is intended to provide Permanently activated dendritic cells having the following characteristics:(M2-1) having projecting dendrites and forming aggregation clusters;(M2-2) being capable of activating unreacted cytotoxic T cells (CTL);(M2-3) having stable properties under the action of anti-CD40 monoclonal antibody; and (M2-4) showing a high expression level of at least one member selected from the group consisting of CD80, CD83 and CD86.
摘要翻译： 旨在提供具有以下（E1）至（E3）特征的终止的树突状细胞：（E1）由于天然免疫刺激剂或永久免疫增强剂的作用而不转化成成熟型;（E2）具有 与未成熟DC相同的形状; 和（E3）表达IL-10。 旨在提供具有以下特征的永久活化的树突细胞：（M2-1）具有突出的树突并形成聚集簇;（M2-2）能够活化未反应的细胞毒性T细胞（CTL）;（M2-3）具有 抗CD40单克隆抗体作用下的稳定性; 和（M2-4）表示选自CD80，CD83和CD86中的至少一种成员的高表达水平。
-
3.发明申请Immunosuppressive Cell-Capturing Material and Immunosuppressive Cell-Capturing Column 有权免疫抑制细胞捕获材料和免疫抑制细胞捕获柱公开(公告)号：US20140017667A1
公开(公告)日：2014-01-16
申请号：US14008538
申请日：2012-03-27
IPC分类号： C12N5/078
CPC分类号： C12N5/0634 , A61K35/14 , A61M1/3679 , B01J20/26 , B01J20/264 , B01J20/28042
摘要： This invention discloses an immunosuppressive cell-capturing material comprising a molded body that includes: a readily hydrolyzable condensation polymer having an amino group; a poorly hydrolyzable polymer coating the readily hydrolyzable condensation polymer; and a ligand-conjugated poorly hydrolyzable polymer coating the poorly hydrolyzable polymer, wherein the ligand is at least one selected from the group consisting of a NH2 group, a secondary amino group, a tertiary amino group, a polyamine residue, a basic cyclic polypeptide residue, an aminoglycosidic compound residue, chloroquine, primaquine, mefloquine, imiquimod, and nystatin, and wherein the content of the amino group in the molded body is 150 μmol/g or less. The invention also discloses an immunosuppressive cell-capturing column filled with the capturing material.
摘要翻译： 本发明公开了一种免疫抑制细胞捕获材料，其包含成型体，其包含：具有氨基的容易水解的缩聚物; 涂覆易水解的缩合聚合物的难溶于水的聚合物; 和配合物共轭的难以水解的聚合物，其涂覆不易水解的聚合物，其中配体是选自NH 2基，仲氨基，叔氨基，多胺残基，碱性环状多肽残基中的至少一种 ，氨基糖苷类化合物残基，氯喹，普氨氨酸，甲氟喹，咪喹莫特和制霉菌素，其中成型体中氨基的含量为150mol / g以下。 本发明还公开了一种填充有捕获材料的免疫抑制细胞捕获柱。
-
4.发明授权Immunosuppressive cell-capturing material and immunosuppressive cell-capturing column 有权免疫抑制细胞捕获材料和免疫抑制细胞捕获柱公开(公告)号：US09127250B2
公开(公告)日：2015-09-08
申请号：US14008538
申请日：2012-03-27
CPC分类号： C12N5/0634 , A61K35/14 , A61M1/3679 , B01J20/26 , B01J20/264 , B01J20/28042
摘要： This invention discloses an immunosuppressive cell-capturing material comprising a molded body that includes: a readily hydrolyzable condensation polymer having an amino group; a poorly hydrolyzable polymer coating the readily hydrolyzable condensation polymer; and a ligand-conjugated poorly hydrolyzable polymer coating the poorly hydrolyzable polymer, wherein the ligand is at least one selected from the group consisting of a NH2 group, a secondary amino group, a tertiary amino group, a polyamine residue, a basic cyclic polypeptide residue, an aminoglycosidic compound residue, chloroquine, primaquine, mefloquine, imiquimod, and nystatin, and wherein the content of the amino group in the molded body is 150 μmol/g or less. The invention also discloses an immunosuppressive cell-capturing column filled with the capturing material.
摘要翻译： 本发明公开了一种免疫抑制细胞捕获材料，其包含成型体，其包含：具有氨基的容易水解的缩聚物; 涂覆易水解的缩合聚合物的难溶于水的聚合物; 和配合物共轭的难以水解的聚合物，其涂覆不易水解的聚合物，其中配体是选自NH 2基，仲氨基，叔氨基，多胺残基，碱性环状多肽残基中的至少一种 ，氨基糖苷类化合物残基，氯喹，普氨氨酸，甲氟喹，咪喹莫特和制霉菌素，其中成型体中的氨基含量为150μmol/ g以下。 本发明还公开了一种填充有捕获材料的免疫抑制细胞捕获柱。
-
-
-
搜索结果
4 条记录 (耗时 0.018 秒)
