公开(公告)号：US09127250B2

公开(公告)日：2015-09-08

申请号：US14008538

申请日：2012-03-27

申请人： Kazumasa Ogasawara ,  Kazuo Teramoto ,  Yuji Ueda ,  Yasushi Itoh ,  Hirohito Ishigaki

发明人： Kazumasa Ogasawara ,  Kazuo Teramoto ,  Yuji Ueda ,  Yasushi Itoh ,  Hirohito Ishigaki

IPC分类号： C12N5/078 ,  B01J20/26 ,  B01J20/28 ,  A61M1/36 ,  A61K35/14

CPC分类号： C12N5/0634 ,  A61K35/14 ,  A61M1/3679 ,  B01J20/26 ,  B01J20/264 ,  B01J20/28042

摘要： This invention discloses an immunosuppressive cell-capturing material comprising a molded body that includes: a readily hydrolyzable condensation polymer having an amino group; a poorly hydrolyzable polymer coating the readily hydrolyzable condensation polymer; and a ligand-conjugated poorly hydrolyzable polymer coating the poorly hydrolyzable polymer, wherein the ligand is at least one selected from the group consisting of a NH2 group, a secondary amino group, a tertiary amino group, a polyamine residue, a basic cyclic polypeptide residue, an aminoglycosidic compound residue, chloroquine, primaquine, mefloquine, imiquimod, and nystatin, and wherein the content of the amino group in the molded body is 150 μmol/g or less. The invention also discloses an immunosuppressive cell-capturing column filled with the capturing material.

摘要翻译： 本发明公开了一种免疫抑制细胞捕获材料，其包含成型体，其包含：具有氨基的容易水解的缩聚物; 涂覆易水解的缩合聚合物的难溶于水的聚合物; 和配合物共轭的难以水解的聚合物，其涂覆不易水解的聚合物，其中配体是选自NH 2基，仲氨基，叔氨基，多胺残基，碱性环状多肽残基中的至少一种 ，氨基糖苷类化合物残基，氯喹，普氨氨酸，甲氟喹，咪喹莫特和制霉菌素，其中成型体中的氨基含量为150μmol/ g以下。 本发明还公开了一种填充有捕获材料的免疫抑制细胞捕获柱。

公开(公告)号：US20140017667A1

公开(公告)日：2014-01-16

申请号：US14008538

申请日：2012-03-27

申请人： Kazumasa Ogasawara ,  Kazuo Teramoto ,  Yuji Ueda ,  Yasushi Itoh ,  Hirohito Ishigaki

发明人： Kazumasa Ogasawara ,  Kazuo Teramoto ,  Yuji Ueda ,  Yasushi Itoh ,  Hirohito Ishigaki

IPC分类号： C12N5/078

CPC分类号： C12N5/0634 ,  A61K35/14 ,  A61M1/3679 ,  B01J20/26 ,  B01J20/264 ,  B01J20/28042

摘要： This invention discloses an immunosuppressive cell-capturing material comprising a molded body that includes: a readily hydrolyzable condensation polymer having an amino group; a poorly hydrolyzable polymer coating the readily hydrolyzable condensation polymer; and a ligand-conjugated poorly hydrolyzable polymer coating the poorly hydrolyzable polymer, wherein the ligand is at least one selected from the group consisting of a NH2 group, a secondary amino group, a tertiary amino group, a polyamine residue, a basic cyclic polypeptide residue, an aminoglycosidic compound residue, chloroquine, primaquine, mefloquine, imiquimod, and nystatin, and wherein the content of the amino group in the molded body is 150 μmol/g or less. The invention also discloses an immunosuppressive cell-capturing column filled with the capturing material.

摘要翻译： 本发明公开了一种免疫抑制细胞捕获材料，其包含成型体，其包含：具有氨基的容易水解的缩聚物; 涂覆易水解的缩合聚合物的难溶于水的聚合物; 和配合物共轭的难以水解的聚合物，其涂覆不易水解的聚合物，其中配体是选自NH 2基，仲氨基，叔氨基，多胺残基，碱性环状多肽残基中的至少一种 ，氨基糖苷类化合物残基，氯喹，普氨氨酸，甲氟喹，咪喹莫特和制霉菌素，其中成型体中氨基的含量为150mol / g以下。 本发明还公开了一种填充有捕获材料的免疫抑制细胞捕获柱。