公开(公告)号：US20130237609A1

公开(公告)日：2013-09-12

申请号：US13880521

申请日：2011-10-19

申请人： Kevin J. Edgar ,  Bin Li ,  Lynne Taylor ,  Grace Ilevbare ,  Stephanie M. Williams

发明人： Kevin J. Edgar ,  Bin Li ,  Lynne Taylor ,  Grace Ilevbare ,  Stephanie M. Williams

IPC分类号： A61K31/12

CPC分类号： A61K31/12 ,  A61K9/1652 ,  A61K31/05 ,  A61K31/352 ,  A61K31/37

摘要： The present invention relates to delivery systems to enhance the bioavailability of flavonoids to improve human health. Flavonoids of interest include but are not limited to curcumin, resveratrol, ellagic acid, naringenin, and quercetin. Flavonoids are important in part because they are known to have beneficial effects on human health, including cardioprotective, antioxidant, and anticancer effects. Utility has been limited by low bioavailability, both in the sense of requiring high doses and in that it has been difficult to carry out proper dose-response studies in the absence of methods to control the actual dose administered. In addition to pharmaceutical applications, there are potential nutraceutical uses, for example in supplements that might be sold in health food stores and pharmacies.

摘要翻译： 本发明涉及递送系统以提高类黄酮的生物利用度以改善人体健康。 感兴趣的类黄酮包括但不限于姜黄素，白藜芦醇，鞣花酸，柚皮苷和槲皮素。 黄酮类化合物很重要，部分原因是它们对人体健康有益，包括心脏保护作用，抗氧化剂和抗癌作用。 实用性受到低生物利用度的限制，无论是在需要高剂量的意义上，并且在没有控制施用实际剂量的方法的情况下难以进行适当的剂量反应研究。 除了制药应用之外，还有潜在的营养保健用途，例如可能在保健食品商店和药店销售的补充品。