公开(公告)号：US20130261015A1

公开(公告)日：2013-10-03

申请号：US13850872

申请日：2013-03-26

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Yeong Hee AHN ,  Jong Shin YOO ,  Park Min SHIN

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/57438

Abstract: A method for diagnosing cancer using information on aberrant glycosylation of glycoproteins, which is related with cancer progression. More particularly, the present invention relates to a peptide marker for cancer diagnosis and a method for diagnosing cancer using the peptide marker, wherein glycoproteins aberrantly glycosylated due to cancer incidence and progression is isolated using lectin; and marker peptides generated by hydrolysis or the glycoproteins isolated by the lectin is selected and quantified.

Abstract translation: 使用与癌症进展相关的糖蛋白异常糖基化的信息诊断癌症的方法。 更具体地，本发明涉及用于癌症诊断的肽标记物和使用肽标记物诊断癌症的方法，其中使用凝集素分离由于癌症发生和进展而异常糖基化的糖蛋白; 选择并定量通过水解产生的标记肽或由凝集素分离的糖蛋白。

公开(公告)号：US20140335535A1

公开(公告)日：2014-11-13

申请号：US14205974

申请日：2014-03-12

Applicant: Korea Basic Science Institute

Inventor： Yeong Hee AHN ,  Jong Shin YOO

IPC: G01N33/574

CPC classification number: G01N33/57423

Abstract: The present invention relates to a peptide marker for cancer diagnosis and a cancer diagnosis method using the same, more precisely to a peptide marker for cancer diagnosis screened by the following steps: separating and concentrating glycoproteins including a certain glycan chain related to the occurrence of cancer; hydrolyzing the glycoproteins to obtain polypeptides; and quantitatively analyzing the polypeptides to identify certain polypeptides that can track quantitative changes in glycoproteins glycosylated in a specific manner by the occurrence of cancer, and to a cancer diagnosis method using the said peptide marker.

Abstract translation: 本发明涉及用于癌症诊断的肽标记物和使用该标记物的癌症诊断方法，更准确地说涉及通过以下步骤筛选的癌症诊断用肽标记物：分离和浓缩包括与癌症发生相关的某种聚糖链的糖蛋白 ; 水解糖蛋白以获得多肽; 并且定量分析多肽以鉴定可以通过癌症的发生以特定方式糖基化的糖蛋白的定量变化以及使用所述肽标记物的癌症诊断方法来鉴定某些多肽。