公开(公告)号：US11320425B2

公开(公告)日：2022-05-03

申请号：US16341852

申请日：2018-03-06

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Joon Seok Lee ,  Seok Lee ,  Man Ho Choi ,  Hee Soo Pyo ,  Seung Ki Kim ,  Jae Young Kim

IPC: G01N33/543 ,  C09K11/02 ,  C09K11/77 ,  G01N21/3577

Abstract: Disclosed is a diagnostic kit for quickly diagnosing a target material with high sensitivity using nanoparticles that absorb infrared light and emit infrared light, in which the nanoparticles are maintained in particle size and have enhanced emission intensity.

公开(公告)号：US08859954B1

公开(公告)日：2014-10-14

申请号：US14045359

申请日：2013-10-03

Applicant: Korea Institute of Science and Technology

Inventor： Man Ho Choi ,  Bong Chul Chung ,  Hyun Hwa Son ,  Eun Gyong Yoo

IPC: B01D59/44 ,  G01N30/72 ,  G01N33/92

CPC classification number: G01N33/92 ,  G01N30/7206 ,  G01N2030/8822 ,  Y10T436/24

Abstract: Disclosed herein is a method for discriminating sitosterolemia by simultaneously measuring relative concentrations of phytosterol and cholesterol metabolism-related compounds in a blood spot on the paper. According to the present disclosure, sitosterolemia may be quickly discriminated with high accuracy by simple sample collecting using a trace amount of blood spot stained on a paper, and it may be used for newborn screening and preschool children, particularly patients with xanthoma.

Abstract translation: 本文公开了通过同时测量纸上血斑中植物甾醇和胆固醇代谢相关化合物的相对浓度来鉴别静脉麻醉的方法。 根据本公开，通过使用在纸上染色的微量血斑的简单样本采集，可以高度准确地鉴别出静脉硬化症，并且可以用于新生儿筛查和学龄前儿童，特别是黄瘤病人。

公开(公告)号：US20190324027A1

公开(公告)日：2019-10-24

申请号：US16341852

申请日：2018-03-06

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Joon Seok Lee ,  Seok Lee ,  Man Ho Choi ,  Hee Soo PYO ,  Seung Ki KIM ,  Jae Young KIM

IPC: G01N33/543 ,  C09K11/77 ,  C09K11/02 ,  G01N21/3577

Abstract: Disclosed is a diagnostic kit for quickly diagnosing a target material with high sensitivity using nanoparticles that absorb infrared light and emit infrared light, in which the nanoparticles are maintained in particle size and have enhanced emission intensity.

公开(公告)号：US11360105B2

公开(公告)日：2022-06-14

申请号：US16395069

申请日：2019-04-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Chae Lin Lee ,  Jung Hee Kim ,  Man Ho Choi

IPC: G01N33/48 ,  G01N33/74

Abstract: The present invention relates to a method for evaluating metabolic activity based on the concentrations of cortisol and its precursors and metabolites thereof in saliva collected by a swab for the measurement of adrenal steroids relating to biochemical stress evaluation and more particularly, to a method of comparing metabolic activity of physiologically different adrenal steroids by analyzing adrenal steroids including cortisol and cortisone extracted from a trace amount of saliva by mass spectrometry and evaluating the metabolic ratio between the two compounds as well as the absolute amount of each compound. Accordingly, the present invention can be utilized as an index for evaluating response to biochemical stress and related diseases by measuring the amounts of adrenal steroids including cortisol and cortisone in a trace amount of saliva collected with a swab.