公开(公告)号：US20180078498A1

公开(公告)日：2018-03-22

申请号：US15562278

申请日：2016-03-16

Applicant: LEO Pharma A/S

Inventor： Karsten Petersson ,  Karen Margrethe Engell ,  Jorgen Jansson ,  Kim Troensegaard Nielsen ,  Andre Huss Eriksson ,  Anne Moore ,  Sonja Vucen ,  Caroline O'Sullivan ,  Abina Crean

IPC: A61K9/00 ,  A61K31/573 ,  A61K31/59 ,  A61K47/34 ,  A61K47/32 ,  A61M37/00

CPC classification number: A61K9/0021 ,  A61K31/573 ,  A61K31/59 ,  A61K31/593 ,  A61K47/32 ,  A61K47/34 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61M2037/0061 ,  A61K2300/00

Abstract: The present invention relates to a microneedle patch composition comprising one or more microneedles each comprising: (a) a tapered tip portion containing a therapeutically active ingredient dispersed in a matrix of a biodegradable polymer capable of providing sustained release of the therapeutically active ingredient over a period of at least two days after insertion of the microneedle or microneedles into the skin, and (b) a fast dissolving microneedle backing layer portion containing a water-soluble polymer overlayering the tip portion, said microneedle or microneedles being attached to and extending from an adhesive surface of a removable substrate.