公开(公告)号：US20200335176A1

公开(公告)日：2020-10-22

申请号：US16851472

申请日：2020-04-17

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Fiona Hyland ,  Asha KAMAT ,  Timothy LOONEY

IPC: G16B20/20 ,  G06N3/12 ,  G06F16/2457 ,  G06F16/248

Abstract: The method includes compressing numbers of reads data for targeted genes of a gene expression assay performed on a test sample. The targeted genes are organized into categories. Each category represents a functional context associated with the targeted genes in that category. The numbers of reads corresponding to targeted genes each category is compressed to form a compressed value for the category. The compressed value is compared to a baseline value for the category to determine an enrichment or a loss of a signature corresponding to the functional context of the category. The method may include analyzing information from multiple assays performed on the test sample, assigning a score value to each assay result and predicting a response to immune-oncology treatment based on the assigned scores.