公开(公告)号：US12258477B2

公开(公告)日：2025-03-25

申请号：US17150247

申请日：2019-08-08

Applicant: Life Technologies Corporation

Inventor： Jongtae Yang ,  Xin Wang ,  Yi-Zhen Hu ,  Kyle Gee ,  Aimei Chen ,  Aleksey Rukavishnikov

IPC: C09B11/28 ,  C07F7/08 ,  C07F9/6561 ,  C12Q1/6816 ,  C12Q1/6869 ,  G01N33/58

Abstract: Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are SiR dyes comprising at least one vinyl group attached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of SiR compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples.