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公开(公告)号:US20050181481A1
公开(公告)日:2005-08-18
申请号:US11103035
申请日:2005-04-11
申请人: Lori Friedman , Gregory Plowman , Roel Funke , Marcia Belvin , Danxi Li , Stephanie Robertson
发明人: Lori Friedman , Gregory Plowman , Roel Funke , Marcia Belvin , Danxi Li , Stephanie Robertson
IPC分类号: G01N33/50 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/574 , G01N33/68 , C12P21/02 , C07H21/04 , C07K14/705
CPC分类号: G01N33/5008 , A01K2227/706 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/502 , G01N33/5091 , G01N33/574 , G01N33/57419 , G01N33/57449 , G01N33/5748 , G01N33/57496 , G01N33/6872 , G01N2333/82 , G01N2333/914 , G01N2500/10
摘要: Human HADH genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of HADH are provided.
摘要翻译: 人HADH基因被鉴定为p21途径的调节剂,因此是与缺陷型p21功能相关的病症的治疗靶点。 提供了鉴定p21调节剂的方法,包括筛选调节HADH活性的药剂。
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公开(公告)号:US20050186200A1
公开(公告)日:2005-08-25
申请号:US11103068
申请日:2005-04-11
申请人: Lori Friedman , Gregory Plowman , Roel Funke , Marcia Belvin , Danxi Li , Stephanie Robertson
发明人: Lori Friedman , Gregory Plowman , Roel Funke , Marcia Belvin , Danxi Li , Stephanie Robertson
IPC分类号: G01N33/50 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/574 , G01N33/68 , A61K39/395 , A61K38/22
CPC分类号: G01N33/5008 , A01K2227/706 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/502 , G01N33/5091 , G01N33/574 , G01N33/57419 , G01N33/57449 , G01N33/5748 , G01N33/57496 , G01N33/6872 , G01N2333/82 , G01N2333/914 , G01N2500/10
摘要: Human HADH genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of HADH are provided.
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