公开(公告)号：US12117453B2

公开(公告)日：2024-10-15

申请号：US16708312

申请日：2019-12-09

Applicant: Washington University ,  Istituti Clinici Scientifici Maugeri SpA SB

Inventor： Jonathan Silva ,  Wandi Zhu ,  Silvia Priori ,  Andrea Mazzanti ,  Kristen Naegle

IPC: G01N33/68 ,  C12N15/10 ,  G01N33/50 ,  G05B23/02 ,  G16C20/30

CPC classification number: G01N33/6872 ,  C12N15/102 ,  G01N33/5061 ,  G05B23/024 ,  G16C20/30 ,  G01N2800/52

Abstract: Disclosed herein is a method for predicting a patient response to a sodium ion channel blocker such as mexiletine when the patient has LQT syndrome or an arrhythmia. The method generally comprises determining a plurality of parameters associated with sodium ion channels; generating a model for patient response by using a partial least squared (PLS) regression analysis on said plurality of parameters; and using the model to predict the patient response if the patient is administered a sodium ion channel blocker such as mexiletine.

公开(公告)号：US20240319196A1

公开(公告)日：2024-09-26

申请号：US18576514

申请日：2022-07-06

Applicant: Creatv Micro Tech Inc.

Inventor： Daniel L. Adams ,  Cha-Mei TANG

IPC: G01N33/574 ,  G01N33/569 ,  G01N33/68

CPC classification number: G01N33/57492 ,  G01N33/56972 ,  G01N33/6872

Abstract: Means for predicting (i) multiple organ metastasis and/or multifocal metastatic disease and (ii) overall survival (OS) and progression free survival (PFS) of subjects having cancer are disclosed, where the predictions are based on the number and size of circulating cancer associated macrophage-like cells (CAMLs) found in a biological sample, such as blood, from the subject.

公开(公告)号：US12099067B2

公开(公告)日：2024-09-24

申请号：US17710832

申请日：2022-03-31

Applicant: ASTUTE MEDICAL, INC.

Inventor： Joseph Anderberg ,  Paul McPherson ,  Jeff Gray ,  Kevin Nakamura ,  James Patrick Kampf ,  Thomas Kwan

IPC: G01N33/68

CPC classification number: G01N33/6863 ,  G01N33/6872 ,  G01N33/6893 ,  G01N2333/521 ,  G01N2333/71 ,  G01N2800/347

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of C-C motif chemokine 16, C-C motif chemokine 14, and Tyrosine-protein kinase receptor UFO as diagnostic and prognostic biomarker assays in renal injuries.

公开(公告)号：US12091465B2

公开(公告)日：2024-09-17

申请号：US16637357

申请日：2018-08-14

Applicant: Seoul National University R&DB Foundation

Inventor： Doo Hyun Chung ,  Eugene C. Yi ,  Dongjin Jeong ,  Min Jueng Kang ,  Donghyun Kim

IPC: C07K14/705 ,  A61P19/02 ,  C07K14/71 ,  C07K16/28 ,  C12N15/113 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/2878 ,  A61P19/02 ,  C07K14/70578 ,  C07K14/70596 ,  C12N15/113 ,  C12N15/1138 ,  G01N33/6872 ,  A61K2039/505 ,  C12N2310/11 ,  C12N2310/14 ,  G01N2333/70578

Abstract: The present invention relates to a composition for preventing or treating diseases caused by overexpression of chemokine CX3CL1 (fractalkine) comprising a death receptor 5 (DR5) inhibitor as an active ingredient, a method for preventing or treating diseases caused by overexpression of chemokine CX3CL1 comprising administering a DR5 expression or activity inhibitor to a patient in need of prevention or treatment of diseases caused by overexpression of chemokine CX3CL1 in a therapeutically effective amount, and a use for prevention or treatment of diseases caused by overexpression of chemokine CX3CL1 of a DR5 expression or activity inhibitor.

公开(公告)号：US20240295565A1

公开(公告)日：2024-09-05

申请号：US18405256

申请日：2024-01-05

Applicant: Genentech Inc. ,  University of Copenhagen

Inventor： Jian Mehr-Dean Payandeh ,  Stephan Alexander Pless ,  Han Chow Chua ,  Marc Kschonsak

IPC: G01N33/68 ,  C07K14/47 ,  G01N33/557

CPC classification number: G01N33/6872 ,  C07K14/47 ,  G01N33/557

Abstract: The present disclosure relates, inter alia, to complexes of the Na+ leak channel non-selective protein (NALCN) with FAM155A (also called FAM155; Family with sequence similarity 155 member A), UNC79 (uncoordinated 79), and UNC80 (uncoordinated 80), methods of screening for molecules that modulate the activity of the complex, and identified modulators thereof.

公开(公告)号：US20240247313A1

公开(公告)日：2024-07-25

申请号：US18394729

申请日：2023-12-22

Applicant: University of Virginia Patent Foundation

Inventor： Bankole A. Johnson

IPC: C12Q1/6883 ,  A61K31/4178 ,  A61K45/06 ,  G01N33/68 ,  G01N33/94

CPC classification number: C12Q1/6883 ,  A61K31/4178 ,  A61K45/06 ,  G01N33/6872 ,  G01N33/942 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2800/307 ,  G01N2800/50

Abstract: The gene responsible for encoding SERT has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3′ UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders.

公开(公告)号：US20240173290A1

公开(公告)日：2024-05-30

申请号：US17790218

申请日：2022-01-12

Applicant: GlaxoSmithKline Intellectual Property (No.3) Limited ,  23andMe, Inc.

Inventor： Janet Mary KUMAR ,  Colin Houston McPHEE ,  Adam Mohamed NAGUIB ,  Lea SAROV-BLAT ,  Claire Yvonne Marie TOWNSEND ,  Paul Bryan WREN ,  Clint Emest YOUNG

IPC: A61K31/353 ,  A61K31/4045 ,  A61K31/573 ,  A61K38/48 ,  A61K45/06 ,  C12N5/0793 ,  C12Q1/6809 ,  G01N33/50 ,  G01N33/68

CPC classification number: A61K31/353 ,  A61K31/4045 ,  A61K31/573 ,  A61K38/4893 ,  A61K45/06 ,  C12N5/0619 ,  C12Q1/6809 ,  G01N33/5058 ,  G01N33/6872 ,  C12Q2600/106 ,  C12Y304/24069 ,  G01N2333/4703 ,  G01N2500/10

Abstract: The present disclosure relates to an inhibitor of human TRPM3 for use in the treatment or prevention of migraine. Combination therapies are also described. In other aspects, the present disclosure provides methods for identifying suitable patients, methods for identifying inhibitors of human TRPM3 and cell lines for use in such methods.

公开(公告)号：US11994517B2

公开(公告)日：2024-05-28

申请号：US18000944

申请日：2021-06-16

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Aaron Kauffmann ,  Jon Stradinger

IPC: G01N33/543 ,  B01L3/00 ,  G01N33/68

CPC classification number: G01N33/54326 ,  B01L3/502761 ,  G01N33/54386 ,  G01N33/6872 ,  B01L2200/04 ,  B01L2200/0668 ,  B01L2200/16 ,  B01L2400/043 ,  G01N2333/4737

Abstract: Analytical assay reaction cartridges, kits containing same, and methods of production and use thereof are disclosed. These cartridges include a magnetic assembly that surrounds at least a portion of a sample read window on the cartridge. The cartridge also includes an analytical reagent positioned therewithin, wherein the analytical reagent comprises magnetic beads coated with at least one anti-red blood cell antibody.

公开(公告)号：US11897946B2

公开(公告)日：2024-02-13

申请号：US17458019

申请日：2021-08-26

Applicant: Duke University

Inventor： Edward F. Patz, Jr. ,  Michael J. Campa ,  Elizabeth Gottlin ,  Barton F. Haynes ,  Hua-Xin Liao ,  M. Anthony Moody

IPC: A61K39/395 ,  C07K16/18 ,  C07K14/72 ,  G01N33/68 ,  A61K45/06 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  C07K14/72 ,  G01N33/6872 ,  G01N33/6878 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/4716

Abstract: Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.

公开(公告)号：US11885814B2

公开(公告)日：2024-01-30

申请号：US17585465

申请日：2022-01-26

Applicant: Fred Hutchinson Cancer Research Center

Inventor： Steven Henikoff ,  Hatice Seda Kaya Okur ,  Terri Dawn Bryson ,  Peter James Skene

IPC: G01N33/68 ,  C12Q1/6804 ,  C12N15/10 ,  C12Q1/6841

CPC classification number: G01N33/6872 ,  C12N15/1065 ,  C12Q1/6804 ,  C12Q1/6841 ,  C12Q2522/10

Abstract: A method for detecting the binding of a chromatin-associated factor of interest to a sequence of chromatin DNA in a cell, including: contacting a permeabilized cell or nucleus with a specific binding agent that specifically recognizes the chromatin-associated factor of interest, wherein the specific binding agent is linked to a nuclease that is inactive or an activatable transposome; activating the nuclease or transposase, thereby excising the sequence of chromatin DNA bound to the chromatin-associated factor of interest; isolating the excised DNA; and determining the sequence of the excised DNA, thereby detecting binding of a chromatin-associated factor of interest to a sequence of chromatin DNA in the cell.