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公开(公告)号：US06660495B2
公开(公告)日：2003-12-09
申请号：US10000453
申请日：2001-12-04
IPC分类号： C12P2106
CPC分类号： C07K14/43527 , A61K39/35 , A61K39/36 , C07K1/12 , C07K1/34
摘要： The present invention relates to a process for the controlled enzymatic cleavage of purified and depigmented active allergenic proteins from indoor and outdoor source materials, which process produces fragments of allergens that retain the natural T-lymphocyte stimulating epitopes, but are depleted of IgE-binding B-cell epitopes and complement-activating agents. The invention also relates to the new pharmaceutical products. These allergen fragments do not exhibit the disadvantages of conventional allergenic extracts for immunotherapy and can be safely used to induce a state of specific T-cell anergy and immunological tolerance in allergic human beings.
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公开(公告)号：US06350590B1
公开(公告)日：2002-02-26
申请号：US09530277
申请日：2000-06-23
IPC分类号： A61K3935
CPC分类号： C07K14/43527 , A61K39/35 , A61K39/36 , C07K1/12 , C07K1/34
摘要： The present invention relates to a process for the controlled enzymatic cleavage of purified and depigmented active allergenic proteins from indoor and outdoor source materials, which process produces fragments of allergens that retain the the natural T-lymphocyte stimulating epitopes, but are depleted of IgE-binding B-cell epitopes and complement-activating agents. The invention also relates to the new pharmaceutical products. These allergen fragments do not exhibit the disadvantages of conventional allergenic extracts for immunotherapy and can be safely used to induce a state of specific T-cell anergy and immunological tolerance in allergic human beings.
摘要翻译： 本发明涉及从室内和室外来源材料中对被纯化和脱色的活性变应原蛋白进行受控酶切割的方法，该方法产生保留天然T淋巴细胞刺激表位但是耗尽IgE结合的变应原片段 B细胞表位和补体活化剂。 本发明还涉及新的药物产品。 这些变应原片段不表现出常规的过敏原提取物用于免疫治疗的缺点，并且可以安全地用于诱导过敏人体中特异性T细胞无反应性和免疫耐受性的状态。
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