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12 条记录 (耗时 0.01 秒)

    Engineered acarid allergen and process for producing the same
    3.
    发明授权
    Engineered acarid allergen and process for producing the same 失效
    工程化螨变应原及其生产方法

    公开(公告)号：US06187311B1

    公开(公告)日：2001-02-13

    申请号：US08930264

    申请日：1997-09-26

    申请人： Chiharu Nishiyama ,  Toshifumi Yuuki ,  Yasushi Okumura

    发明人： Chiharu Nishiyama ,  Toshifumi Yuuki ,  Yasushi Okumura

    IPC分类号： A61K3935

    CPC分类号： C07K14/43531 ,  A61K38/00

    摘要： The invention provides a method for producing a modified major mite allergen, obtained by altering a major allergen of house dust mites by gene engineering, which involve the steps of culturing prokaryotic or eukaryotic host cells transformed with a replication vector containing a gene encoding modified major mite allergen expressed from a promoter and collecting the expressed modified major mite allergen from the culture. The present invention provides a modified major mite allergen produced by the method, DNA molecules encoding same, and a pharmaceutical composition containing the modified major mite allergen.

    摘要翻译： 本发明提供了通过基因工程改变房尘螨的主要变应原而获得的改性的主要螨变应原的方法，其涉及培养用含有编码修饰的主要螨的基因的复制载体转化的原核或真核宿主细胞的步骤 由启动子表达的变应原并从培养物中收集表达的修饰的主要螨变应原。 本发明提供了通过该方法生产的修饰的主要螨变应原，编码它的DNA分子和含有改性的主要螨变应原的药物组合物。

    Protein allergens of the species Cynodon dactylon
    8.
    发明授权
    Protein allergens of the species Cynodon dactylon 失效
    Cynodon dactylon种的蛋白质过敏原

    公开(公告)号：US06214358B1

    公开(公告)日：2001-04-10

    申请号：US08441507

    申请日：1995-05-15

    申请人： Mohan Bir Singh ,  Penelope Smith ,  Robert Bruce Knox

    发明人： Mohan Bir Singh ,  Penelope Smith ,  Robert Bruce Knox

    IPC分类号： A61K3935

    CPC分类号： C07K14/415 ,  A61K38/00

    摘要： The present invention provides nucleic acid sequences coding Cyn d I, or at least one fragment thereof or the functional equivalent of such nucleic acid sequences. The present invention also provides expression vectors comprising such nucleic acid sequences and host cells transformed therewith. The present invention further provides isolated Bermuda grass pollen protein allergen Cyn d I or fragments thereof. Isolated Bermuda grass pollen protein allergens or antigenic or allergenic fragments thereof are useful for diagnosing and treating sensitivity in an individual to Bermuda grass pollen allergens.

    摘要翻译： 本发明提供了编码Cynd I或其至少一个片段或这些核酸序列的功能等同物的核酸序列。 本发明还提供了包含这种核酸序列的表达载体和用其转化的宿主细胞。 本发明还提供了分离的百慕大草花粉蛋白过敏原Cynd I或其片段。 分离的百慕大草花粉蛋白过敏原或其抗原或过敏性片段可用于诊断和治疗个体对百慕大草花粉过敏原的敏感性。

    Cloning and sequencing of allergens of dermatophagoides house dust mite
    9.
    发明授权
    Cloning and sequencing of allergens of dermatophagoides house dust mite 失效
    皮肤癣菌过敏原的克隆和测序房尘螨

    公开(公告)号：US06423837B1

    公开(公告)日：2002-07-23

    申请号：US09295188

    申请日：1999-04-20

    申请人： Wayne Robert Thomas ,  Kaw-Yan Chua

    发明人： Wayne Robert Thomas ,  Kaw-Yan Chua

    IPC分类号： A61K3935

    CPC分类号： C07K14/5403 ,  A61K38/00 ,  C07K14/43531

    摘要： Isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, DNA encoding two major D. farinae allergens, Der f I and Der f II and DNA encoding a D. pteronyssinus allergen, Der p I. In addition, the proteins or peptides encoded by the isolated DNA, their use as diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens.

    摘要翻译： 编码Dermatophagoides（房尘螨）变应原的分离的DNA，特别是Dermatophagoides farinae和Dermatophagoides pteronyssinus，它们是蛋白质过敏原或包括蛋白质变应原的至少一个表位的肽。 特别地，编码两个主要的D. farinae过敏原的DNA，Der f I和Der f II以及编码D.pteronyssinus变应原的DNA，Der p I.另外，由分离的DNA编码的蛋白质或肽，它们用作诊断和 诊断和治疗房屋尘螨过敏原敏感性的治疗试剂和方法。

    Tolerogenic fragments of natural allergens
    10.
    发明授权
    Tolerogenic fragments of natural allergens 有权
    天然过敏原的耐受性碎片

    公开(公告)号：US06350590B1

    公开(公告)日：2002-02-26

    申请号：US09530277

    申请日：2000-06-23

    申请人： Lubertus Berrens ,  Maria Leticia Gonzales Romano ,  Maria Teresa Gallego Camara

    发明人： Lubertus Berrens ,  Maria Leticia Gonzales Romano ,  Maria Teresa Gallego Camara

    IPC分类号： A61K3935

    CPC分类号： C07K14/43527 ,  A61K39/35 ,  A61K39/36 ,  C07K1/12 ,  C07K1/34

    摘要： The present invention relates to a process for the controlled enzymatic cleavage of purified and depigmented active allergenic proteins from indoor and outdoor source materials, which process produces fragments of allergens that retain the the natural T-lymphocyte stimulating epitopes, but are depleted of IgE-binding B-cell epitopes and complement-activating agents. The invention also relates to the new pharmaceutical products. These allergen fragments do not exhibit the disadvantages of conventional allergenic extracts for immunotherapy and can be safely used to induce a state of specific T-cell anergy and immunological tolerance in allergic human beings.

    摘要翻译： 本发明涉及从室内和室外来源材料中对被纯化和脱色的活性变应原蛋白进行受控酶切割的方法，该方法产生保留天然T淋巴细胞刺激表位但是耗尽IgE结合的变应原片段 B细胞表位和补体活化剂。 本发明还涉及新的药物产品。 这些变应原片段不表现出常规的过敏原提取物用于免疫治疗的缺点，并且可以安全地用于诱导过敏人体中特异性T细胞无反应性和免疫耐受性的状态。