公开(公告)号：US11236050B2

公开(公告)日：2022-02-01

申请号：US16771096

申请日：2018-12-08

申请人： MSN LABORATORIES PRIVATE LIMITED, R&D CENTER ,  Thirumalai Rajan Srinivasan

发明人： Thirumalai Rajan Srinivasan ,  Eswaraiah Sajja ,  Venkata Panakala Rao Gogulapati ,  Rajeshwar Reddy Sagyam ,  Pavan Kumar Reddy Bandla ,  Srinivasulu Rangineni

IPC分类号： C07D215/18 ,  C07D215/48

摘要： The present invention relates to novel polymorphs of 4-[3-chloro-4-(N′-cyclopropyl ureido) phenoxy]-7-methoxyquinoline-6-carboxamide methanesulfonate represented by following structural formula-1a and process for preparation thereof. Further, the present invention relates to an improved process for the preparation of 4-[3-chloro-4-(N′-cyclopropylureido) phenoxy]-7-methoxyquinoline-6-carboxamide compound of formula-1 or its salts and its intermediates thereof.

公开(公告)号：US11149026B2

公开(公告)日：2021-10-19

申请号：US16645472

申请日：2018-09-07

申请人： MSN LABORATORIES PRIVATE LIMITED, R&D CENTER

发明人： Thirumalai Rajan Srinivasan ,  Eswaraiah Sajja ,  Venkat Reddy Ghojala ,  Rajeshwar Reddy Sagyam ,  Srinivasulu Rangineni ,  Rajashekar Kommera ,  Markandeya Bekkam

IPC分类号： C07D403/06

摘要： The present invention relates to solid state forms of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione hydrochloride compound of formula-1a and their processes for the preparation thereof and an improved process for the preparation of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione hydrochloride. The present inventors also provides an amorphous polymorph of the combination drug consisting of 2′-deoxy-5-(trifluoromethyl) uridine and 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione monohydrochloride and its process for the preparation.