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![IMPROVED PROCESS FOR THE PREPARATON OF PURE (1'R,6R,6aR,7R,13S,14S,16R)-5-(ACETYLOXY)-3',4',6,6a,7,13,14,16-OCTAHYDRO-6',8,14-TRIHYDROXY-7',9-DIMETHOXY-4,10,23-TRIMETHYLSPIRO[6,16-(EPITHIOPROPANOXYMETH ANO)-7,13-IMINO-12H-1,3-DIOXOLO[7,8]ISOQUINO[3,2-b][3]BENZAZOCINE-20,1'(2'H)-ISOQUINOLIN]-19-ONE POLYMORPH THERE OF](/abs-image/US/2022/10/06/US20220315605A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220315605A1
公开(公告)日：2022-10-06
申请号：US17623041
申请日：2020-06-29
发明人： Thirumalai Rajan SRINIVASAN , Eswaraiah SAJJA , Rajeshwar Reddy SAGYAM , Navin Kumar Reddy KESHAVAREDDY
IPC分类号： C07D515/22
摘要： The present invention provides pure (1′R,6R,6aR,7R,13S,14S,16R)-5-(acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethyl spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7, 8]isoquino[3,2-b][3] benzazocine-20,1′(211)-isoquinolin]-19-one of formula (1) substantially free from one or more impurities selected from intermediate compound of formula (50), cyclic impurity of formula (A), deshydroxy impurity of formula (B) and hydroxy impurity of formula (C).
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2.发明授权公开(公告)号：US07790886B2
公开(公告)日：2010-09-07
申请号：US12348360
申请日：2009-01-05
申请人： Manne Satyanarayana Reddy , Thirumalai Rajan Srinivasan , Venka Bhaskara Rao Uppala , Mummadi Venkatesh , Akundi Surya Prabhakar
发明人： Manne Satyanarayana Reddy , Thirumalai Rajan Srinivasan , Venka Bhaskara Rao Uppala , Mummadi Venkatesh , Akundi Surya Prabhakar
IPC分类号： C07D409/14
CPC分类号： C07D417/12
摘要： The present invention is related to crystalline forms of ziprasidone and its hydrochloride salt and an amorphous form of ziprasidone hydrochloride and the process for the preparation thereof. The crystalline forms and amorphous form of the invention are suitable for pharmaceutical purposes in the treatment of psychosis. The processes of the invention are simple, non-hazardous and commercially suitable.
摘要翻译： 本发明涉及齐拉西酮及其盐酸盐和无定形形式的齐拉西酮盐酸盐的结晶形式及其制备方法。 本发明的结晶形式和无定形形式适用于治疗精神病的药物目的。 本发明的方法是简单的，非危险的，商业上合适的。
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3.发明授权公开(公告)号：US07488729B2
公开(公告)日：2009-02-10
申请号：US10729837
申请日：2003-12-04
申请人： Manne Satyanarayana Reddy , Thirumalai Rajan Srinivasan , Venka Bhaskara Rao Uppala , Mummadi Venkatesh , Akundi Surya Prabhakar
发明人： Manne Satyanarayana Reddy , Thirumalai Rajan Srinivasan , Venka Bhaskara Rao Uppala , Mummadi Venkatesh , Akundi Surya Prabhakar
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D417/12
摘要： The present invention is related to crystalline forms of ziprasidone and its hydrochloride salt and an amorphous form of ziprasidone hydrochloride and the process for the preparation thereof. The crystalline forms and amorphous form of the invention are suitable for pharmaceutical purposes in the treatment of psychosis. The processes of the invention are simple, non-hazardous and commercially suitable.
摘要翻译： 本发明涉及齐拉西酮及其盐酸盐和无定形形式的齐拉西酮盐酸盐的结晶形式及其制备方法。 本发明的结晶形式和无定形形式适用于治疗精神病的药物目的。 本发明的方法是简单的，非危险的，商业上合适的。
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![Polymorphs of 4-[3-chloro-4-(n′-cyclopropyl ureido)phenoxy] -7-methoxyquinoline-6-carboxamide, its salts and process for the preparation thereof](/abs-image/US/2022/02/01/US11236050B2/abs.jpg.150x150.jpg)
公开(公告)号：US11236050B2
公开(公告)日：2022-02-01
申请号：US16771096
申请日：2018-12-08
发明人： Thirumalai Rajan Srinivasan , Eswaraiah Sajja , Venkata Panakala Rao Gogulapati , Rajeshwar Reddy Sagyam , Pavan Kumar Reddy Bandla , Srinivasulu Rangineni
IPC分类号： C07D215/18 , C07D215/48
摘要： The present invention relates to novel polymorphs of 4-[3-chloro-4-(N′-cyclopropyl ureido) phenoxy]-7-methoxyquinoline-6-carboxamide methanesulfonate represented by following structural formula-1a and process for preparation thereof. Further, the present invention relates to an improved process for the preparation of 4-[3-chloro-4-(N′-cyclopropylureido) phenoxy]-7-methoxyquinoline-6-carboxamide compound of formula-1 or its salts and its intermediates thereof.
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公开(公告)号：US20210155651A1
公开(公告)日：2021-05-27
申请号：US17044310
申请日：2019-04-04
发明人： Thirumalai Rajan SRINIVASAN , Eswaraiah SAJJA , Venkata Panakala Rao GOGULAPATI , Ganapathi Chary NAGUNURI , Mohammad Rafee SHAIK
摘要： Water soluble iron carbohydrate complex obtainable from an aqueous solution of iron (III) salt and an aqueous solution of the oxidation product of one or more maltrodextrins using an aqueous oxone solution at a pH-value within the alkaline range, where, when one maltodextrin is present, its dextrose equivalent lies between 5 and 20, and when a mixture of several maltodextrins is present, the dextrose equivalent of the mixture lies between 5 and 20 and the dextrose equivalent of each individual maltodextrin contained in the mixture lies between 2 and 40, process for its production and medicament for the treatment and prophylaxis of iron deficiency anaemia conditions.
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![AN IMPROVED PROCESS FOR THE PREPARATION OF 4-({(1 R)-2-[5-(2-FLUORO-3METHOXYPHENYL)-3-{[2-FLUORO-6-(TRIFLUORO METHYL) PHENYL]METHYL}-4-METHYL-2,6-DIOXO-3,6DIHYDROPYRIMIDIN-1(2 H)-YL]-1-PHENYLETHYL}AMINO)BUTANOIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS](/abs-image/US/2023/03/09/US20230072265A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230072265A1
公开(公告)日：2023-03-09
申请号：US17789460
申请日：2020-12-24
IPC分类号： C07D239/54
摘要： The present invention relates to an improved process for the preparation of 4-({(1R)-2-[5-(2-fluoro-3-methoxy phenyl)-3-{[2-fluoro-6-(trifluoro methyl) phenyl] methyl}-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]-1-phenylethyl}amino) butanoic acid of formula (I) or its pharmaceutically acceptable salts. The compound of formula (I) is represented by the following structural formula:
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![POLYMORPHS OF 7-CYCLOPENTYL-N,N-DIMETHYL-2-{[5-(PIPERAZIN-1-YL) PYRIDIN-2-YL]-AMINO}-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND PROCESS FOR THE PREPARATION THEREOF](/abs-image/US/2022/06/30/US20220204514A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220204514A1
公开(公告)日：2022-06-30
申请号：US17606827
申请日：2020-04-29
发明人： Thirumalai Rajan SRINIVASAN , Eswaraiah SAJJA , Satyanarayana REVU , Rajeshwar Reddy SAGYAM , Srinivasulu RANGINENI , Ravichandran SRINIVASAN , Venkata Narasayya SALADI , Naveen RAGAM
IPC分类号： C07D487/04 , C07C57/13 , A61P35/00
摘要： The present invention relates to novel crystalline forms of butanedioic acid 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl) pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide of formula-la and process for preparation thereof. The present invention also relates to a process for the preparation of 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d] pyrimidine-6-carboxamide.
Further, the present application also relates to acid addition salts of 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d] pyrimidine-6-carboxamide and process for the preparation thereof.-
公开(公告)号：US11261160B2
公开(公告)日：2022-03-01
申请号：US16467853
申请日：2017-12-06
申请人： MSN LABORATORIES PRIVATE LIMITED, R&D CENTER , Thirumalai Rajan Srinivasan , Eswaraiah Sajja , Venkata Panakala Rao Gogulapati , Rajeshwar Reddy Sagyam , Shyam Kiran Babu Gandham , Rajesham Boge
发明人： Thirumalai Rajan Srinivasan , Eswaraiah Sajja , Venkata Panakala Rao Gogulapati , Rajeshwar Reddy Sagyam , Shyam Kiran Babu Gandham , Rajesham Boge
IPC分类号： C07D215/233
摘要： The present invention also relates to process for the preparation of N-(4-(6,7-dimethoxy quinolin-4-yloxy)phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-malate compound of formula-1a and its polymorphs thereof, represented by the following structural:
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![NOVEL POLYMORPHS OF 4-[3-CHLORO-4-(N'-CYCLOPROPYL UREIDO)PHENOXY]-7-METHOXYQUINOLINE-6-CARBOXAMIDE, ITS SALTS AND PROCESS FOR THE PREPARATION THEREOF](/abs-image/US/2021/06/24/US20210188778A1/abs.jpg.150x150.jpg)
公开(公告)号：US20210188778A1
公开(公告)日：2021-06-24
申请号：US16771096
申请日：2018-12-08
发明人： Thirumalai Rajan SRINIVASAN , Eswaraiah SAJJA , Venkata Panakala Rao GOGULAPATI , Rajeshwar Reddy SAGYAM , Pavan Kumar Reddy BANDLA , Srinivasulu RANGINENI
IPC分类号： C07D215/48
摘要： The present invention relates to novel polymorphs of 4-[3-chloro-4-(N′-cyclopropyl ureido) phenoxy]-7-methoxyquinoline-6-carboxamide methanesulfonate represented by following structural formula-1a and process for preparation thereof. Further, the present invention relates to an improved process for the preparation of 4-[3-chloro-4-(N′-cyclopropylureido) phenoxy]-7-methoxyquinoline-6-carboxamide compound of formula-1 or its salts and its intermediates thereof.
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10.发明申请POLYMORPHIC FORMS OF ZIPRASIDONEAND ITS HYDROCHLORIDE SALT AND PROCESS FOR PREPARATION THEREOF 失效拉伐沙坦及其盐酸盐的多晶形式及其制备方法公开(公告)号：US20090137605A1
公开(公告)日：2009-05-28
申请号：US12348360
申请日：2009-01-05
申请人： Manne Satyanarayana Reddy , Thirumalai Rajan Srinivasan , Venka Bhaskara Rao Uppala , Mummadi Venkatesh , Akundi Surya Prabhakar
发明人： Manne Satyanarayana Reddy , Thirumalai Rajan Srinivasan , Venka Bhaskara Rao Uppala , Mummadi Venkatesh , Akundi Surya Prabhakar
IPC分类号： A61K31/497 , C07D409/14
CPC分类号： C07D417/12
摘要： The present invention is related to crystalline forms of ziprasidone and its hydrochloride salt and an amorphous form of ziprasidone hydrochloride and the process for the preparation thereof. The crystalline forms and amorphous form of the invention are suitable for pharmaceutical purposes in the treatment of psychosis. The processes of the invention are simple, non-hazardous and commercially suitable.
摘要翻译： 本发明涉及齐拉西酮及其盐酸盐和无定形形式的齐拉西酮盐酸盐的结晶形式及其制备方法。 本发明的结晶形式和无定形形式适用于治疗精神病的药物目的。 本发明的方法是简单的，非危险的，商业上合适的。
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