公开(公告)号：US20180085413A1

公开(公告)日：2018-03-29

申请号：US15280136

申请日：2016-09-29

Applicant: Macau University of Science and Technology

Inventor： Yuen Kwan Law ,  Kam Wai Wong ,  An Gao Wu ,  Liang Liu ,  Zeng Wu

IPC: A61K36/25 ,  A61K31/704 ,  A61K31/56

CPC classification number: A61K36/25 ,  A61K31/19 ,  A61K31/56 ,  A61K31/704 ,  A61K2236/33 ,  A61K2236/35 ,  A61K2236/39 ,  A61P25/28

Abstract: A method for treating a subject suffering from a neurodegenerative disease includes administering at least one triterpenoid which can be obtained from Hedera helix. A method for treating a subject suffering from a neurodegenerative disease includes administering an effective amount of a Hedera helix extract which comprises the triterpenoid. The neurodegenerative disease is preferably but not exclusively Parkinson's disease or Huntington's disease. Methods for extracting the triterpenoid from Hedera helix and a method for inducing autophagy in cells by contacting them with the triterpenoid are also provided. The triterpenoid allows an exceptional induction of autophagy, in particular a significant reduction of the protein level of mutant huntingtin, a significant reduction of the protein level of A53T α-synuclein, a significant inhibition of the oligomerization of α-synuclein and a significant inhibition of the inclusion formation of huntingtin via the AMPK-mTOR dependent autophagy inducing pathway.