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    METHOD OF TREATING REFRACTORY RHEUMATOID ARTHRITIS
    1.
    发明申请
    METHOD OF TREATING REFRACTORY RHEUMATOID ARTHRITIS 审中-公开

    公开(公告)号：US20190008872A1

    公开(公告)日：2019-01-10

    申请号：US15644945

    申请日：2017-07-10

    Applicant: Macau University of Science and Technology

    Inventor： Liang Liu ,  Kam Wai Wong ,  Yuen Kwan Law ,  Cong Ling Qiu

    IPC: A61K31/56 ,  A61K31/519 ,  A61K31/573 ,  A61K31/165

    Abstract: A method for treating a subject suffering from refractory rheumatoid arthritis includes the step of administering an effective amount of a quinonemethide triterpenoid or a pharmaceutically tolerable salt, solvate or anhydrate thereof to the subject. Also is a method for inducing autophagy in a synovial fibroblast, and a method of inducing calcium mobilization in a synovial fibroblast. Further a pharmaceutical composition includes an effective dose of a quinonemethide triterpenoid and an anti-arthritis compound. The quinonemethide triterpenoid is suitable to treat refractory rheumatoid arthritis (RA) in particular ABC-protein-dependent RA and apoptosis-deficient RA. The quinonemethide triterpenoid also possesses significant inhibitory effects on the growth of synovial fibroblasts, in particular modulating the calcium homeostasis in multidrug-resistant rheumatoid arthritis synovial fibroblasts.

    Cobalt-polypyridyl complex for treatment of cancer, a pharmaceutical composition and a kit comprising it
    3.
    发明授权
    Cobalt-polypyridyl complex for treatment of cancer, a pharmaceutical composition and a kit comprising it 有权

    公开(公告)号：US09895338B1

    公开(公告)日：2018-02-20

    申请号：US15242883

    申请日：2016-08-22

    Applicant: Macau University of Science and Technology

    Inventor： Kam Wai Wong ,  Man Chung Wong

    IPC: A61K31/28 ,  A61K31/555 ,  A61K45/06

    CPC classification number: A61K31/555 ,  A61K31/28 ,  A61K45/06 ,  A61K2300/00

    Abstract: A method for treating a subject suffering from a cancer, in particular a multidrug-resistant cancer includes administrating a cobalt-polypyridyl complex to the subject. A method for suppressing the growth of cancer cells, in particular inducing autophagy of the cancer cells, inducing cell cycle arrest of the cancer cells and/or inhibiting cell invasion of the cancer cells and for specifically targeting cancer cells with multidrug-resistance includes contacting said cancer cells with the cobalt-polypyridyl complex. A pharmaceutical composition and a kit are provided and include the cobalt-polypyridyl complex. Unexpectedly, the cobalt-polypyridyl complex is especially suitable to treat cancer, in particular multidrug-resistant cancer with an exceptionally increased cytotoxic activity towards multidrug-resistant cancer cells.

    COBALT-POLYPYRIDYL COMPLEX FOR TREATMENT OF CANCER, A PHARMACEUTICAL COMPOSITION AND A KIT COMPRISING IT
    5.
    发明申请
    COBALT-POLYPYRIDYL COMPLEX FOR TREATMENT OF CANCER, A PHARMACEUTICAL COMPOSITION AND A KIT COMPRISING IT 有权

    公开(公告)号：US20180050044A1

    公开(公告)日：2018-02-22

    申请号：US15242883

    申请日：2016-08-22

    Applicant: Macau University of Science and Technology

    Inventor： Kam Wai Wong ,  Man Chung Wong

    IPC: A61K31/555 ,  A61K45/06

    CPC classification number: A61K31/555 ,  A61K31/28 ,  A61K45/06 ,  A61K2300/00

    Abstract: A method for treating a subject suffering from a cancer, in particular a multidrug-resistant cancer includes administrating a cobalt-polypyridyl complex to the subject. A method for suppressing the growth of cancer cells, in particular inducing autophagy of the cancer cells, inducing cell cycle arrest of the cancer cells and/or inhibiting cell invasion of the cancer cells and for specifically targeting cancer cells with multidrug-resistance includes contacting said cancer cells with the cobalt-polypyridyl complex. A pharmaceutical composition and a kit are provided and include the cobalt-polypyridyl complex. Unexpectedly, the cobalt-polypyridyl complex is especially suitable to treat cancer, in particular multidrug-resistant cancer with an exceptionally increased cytotoxic activity towards multidrug-resistant cancer cells.

    Treatment of subjects with multidrug-resistant cancer
    8.
    发明授权
    Treatment of subjects with multidrug-resistant cancer 有权

    公开(公告)号：US10322097B2

    公开(公告)日：2019-06-18

    申请号：US14971153

    申请日：2015-12-16

    Applicant: Macau University of Science and Technology

    Inventor： Kam Wai Wong ,  Yuen Kwan Law ,  Thomas Efferth ,  Su-Wei Xu ,  Sami Hamdoun ,  Liang Liu

    IPC: A61K31/19 ,  A61K31/337 ,  A61K31/553 ,  A61K31/704 ,  A61K31/7048 ,  A61K33/24

    Abstract: A quinonemethide triterpenoid is administered to subjects with multidrug-resistant cancer, in particular a cancer with enhanced expression and/or functional activity of ABC transporter proteins such as P-glycoprotein and/or an apoptosis-deficient, in particular p53-, Bax- or Bak-deficient, cancer, i.e. specific subgroups of subjects with cancer. The quinonemethide triterpenoid is suitable to treat cancer allowing for an accumulation of cytotoxic or therapeutic compounds in the cells while having exceptionally increased cytotoxic activity towards the multidrug-resistant cancer cells and while allowing for an increased activity of chemotherapeutic compounds. Methods for specifically targeting cancer cells with multidrug-resistance and methods for potentiating the activity of a chemotherapeutic compound in those cancer cells are also disclosed. A kit including a quinonemethide triterpenoid and a chemotherapeutic compound is also provided.

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